Recent advances in the preventative strategies for postoperative adhesions using biomaterial-based membranes and micro/nano-drug delivery systems

Akhlaghi, Sarah; Ebrahimnia, Maryam; Niaki, Darya Shokouhi; Solhi, Mehdi; Rabbani, Shahram; Haeri, Azadeh

doi:10.1016/j.jddst.2023.104539

Cited by 6 publications

(3 citation statements)

References 143 publications

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“…2−5 Biomaterials in various physical forms, capable of physically isolating the wound tissues, have attracted significant interest, 3,6,7 but several problems remain open due to the complexity of the causes of postoperative adhesion, and the antiadhesive barriers prepared under the guidance of straightforward mechanisms are insufficient to fulfill the diverse clinical needs. 2,5 Safe and efficacious strategies for the clinical prevention of postoperative adhesion are still urgently needed.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, there is much interest in the treatment of postoperative adhesion. To date, several strategies have been developed to relieve postoperative adhesion, such as implementing physical barriers, administering pharmacological agents locally or systemically, or a combination of the two. − Biomaterials in various physical forms, capable of physically isolating the wound tissues, have attracted significant interest, ,, but several problems remain open due to the complexity of the causes of postoperative adhesion, and the antiadhesive barriers prepared under the guidance of straightforward mechanisms are insufficient to fulfill the diverse clinical needs. , Safe and efficacious strategies for the clinical prevention of postoperative adhesion are still urgently needed.…”

Section: Introductionmentioning

confidence: 99%

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Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Zhou,

An,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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Surgical bleeding and cumulative oxidative stress are significant factors in the development of postoperative adhesions, which are always associated with adverse patient outcomes. However, effective strategies for adhesion prevention are currently lacking in clinical practice. In this study, we propose a solution using polydopaminedecorated manganese dioxide nanoparticles (MnO 2 @PDA) with rapid hemostasis and remarkable antioxidant properties to prevent postsurgical adhesion. The PDA modification provides MnO 2 @PDA with enhanced tissue adhesiveness and hemocompatibility with negligible hemolysis. Furthermore, MnO 2 @PDA exhibits impressive antioxidant and free radical scavenging properties, protecting cells from the negative effects of oxidative stress. The hemostatic activity of MnO 2 @PDA is evaluated in a mouse truncated tail model and a liver injury model, with results demonstrating reduced bleeding time and volume. The in vivo test on a mouse cecal abrasion model shows that MnO 2 @PDA exhibits excellent antiadhesion properties coupled with alleviated inflammation around the damaged tissue. Therefore, MnO 2 @PDA, which exhibits high biosafety, rapid hemostasis, and beneficial antioxidant capacity, displays exceptional antiadhesion performance, holding great potential for clinical applications to prevent postoperative adhesion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Zhou,

An,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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“…The fluid is safe in combination with intestinal sutures, but it interferes with postoperative CT imaging due to the large amount of free fluid. Therefore, surgeons are somewhat wary of using these products on intestinal sutures, especially in sutures with an increased risk of leakage or in cases of massive contamination [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Immunostimulation for Postoperative Intra-Abdominary Adhesion in an Experimental Rat Model

Puchkina,

Bondarenko,

Mikhaylichenko

et al. 2023

ArveMED

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Purpose of the Study: To analyze the effectiveness of using sodium deoxyribonucleate (SDN) for pelvic adhesions in rats in experiment. Materials and Methods: The experiment was carried out on 90 laboratory rats. Three groups of 30 animals each were formed: group 1 – control; group 2 – rats with a simulated adhesive process in the pelvis without subsequent treatment; group 3 – animals with a model of adhesive process in the pelvis receiving intramuscular SDN for 10 days. The adhesive process in the pelvis was modeled in rats by ligating the uterine horns on both sides. The expression of CD4, CD8, CD20, CD138 was studied using DP-SOFT software program and subsequent statistical processing. Results: In animals of the control group, a small number of cells with expression of CD4+, CD8+ and CD138 markers were found in the parietal peritoneum (PP). In perimetrium (PM), no positively stained cells of the studied immunophenotype were found. In group 2, animals showed an increase in the number of cells in the PP positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. An increase in the number of CD138+ and CD4+ cells was found in the rats’ PM. In group 3, compared to the control, the count of CD4+ cells, CD56+ cells and CD138+ cells significantly increased. In the PM of the operated animals, we found an increase in the number of cells positively expressing CD4+ and CD138+, and the appearance of CD56+ cells. In the PM of rats, an increase in the number of CD138+ and CD4+ cells was noted, which indicates activation of the humoral immune system. In group 3, the count of CD4+, CD56+ and CD138+ – cells in the PP significantly increased compared to the control. PM was characterized by a similar distribution of cells. Conclusion: After surgery, the adhesive process causes a change in the ratio of leukocyte subpopulations in the affected area towards an increase in their number in the parietal peritoneum rather than in the perimetrium. The use of SDN has an immunomodulatory effect and stimulates immune responses by increasing the number of immunocompetent cells in the surgical site.

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Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions

Lv,

Cai,

Zhao

et al. 2024

Adv Funct Materials

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Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives are usually double sided and suffer from poor wet adhesion, nondegradability, and monofunctionality, which limits their application in preventing postoperative adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with a wet adhesive inner layer and an antiadhesive outer layer is prepared by combining electrostatic spun and adhesive materials. By using both capillary suction and a catechol‐based strategy, the wet adhesive strength and interfacial toughness of the Janus bioadhesive reach 98 kPa and 325 J m−2, respectively, which are much higher than those of commercial fibrin glues and cyanoacrylate glues. The electrostatic spun outer layer acts as a physical barrier with antiadhesive and friction‐reducing effects. Additionally, the Janus bioadhesive demonstrates biodegradable, hemostatic, antioxidative, anti‐inflammatory, and prohealing properties. In vivo results show that the asymmetric adhesion effect of the Janus bioadhesive effectively preventing postoperative abdominal and intrauterine adhesions. Notably, tandem mass tags‐labeled quantitative proteomics analysis demonstrate that the expression of inflammatory response‐associated proteins (S100A8, S100A9) is associated with adhesion; the Janus bioadhesive significantly downregulates this expression. Therefore, the OD/GM@PG Janus bioadhesive is a promising candidate for preventing postoperative adhesions.

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Recent advances in the preventative strategies for postoperative adhesions using biomaterial-based membranes and micro/nano-drug delivery systems

Cited by 6 publications

References 143 publications

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Effectiveness of Immunostimulation for Postoperative Intra-Abdominary Adhesion in an Experimental Rat Model

Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions

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Recent advances in the preventative strategies for postoperative adhesions using biomaterial-based membranes and micro/nano-drug delivery systems

Cited by 6 publications

References 143 publications

Biosafe Polydopamine-Decorated MnO2 Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Biosafe Polydopamine-Decorated MnO2 Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Effectiveness of Immunostimulation for Postoperative Intra-Abdominary Adhesion in an Experimental Rat Model

Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions

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Product

Resources

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Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention

Biosafe Polydopamine-Decorated MnO₂ Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention