Recent advances in the modification of carbon-based quantum dots for biomedical applications

Alaghmandfard, Amirhossein; Sedighi, Omid; Rezaei, Nima Tabatabaei; Abedini, Amir; Khachatourian, Adrine Malek; Toprak, Muhammet S.; Seifalian, Alexander M.

doi:10.1016/j.msec.2020.111756

Cited by 130 publications

(77 citation statements)

References 212 publications

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Section: Carbon-based Quantum Dots (Cqds)-based Biosensorsmentioning

confidence: 99%

“…CQDs are divided into 2 subgroups, carbon quantum dots and graphene quantum dots, and can be fabricated using a range of synthesis methods with the 4 main reported to be laser ablation, microwave-assisted synthesis, electrochemical oxidation, and hydro/solvo thermal [89]. The chosen synthesis approach will result in the final structure that can range from fully amorphous through to crystalline and can result in functional groups on the surface [89]. Carbon quantum dots/graphene quantum dots generally have an average diameter of less than 10 nm and are easy to disperse in water, readily functionalised, relatively cheap, easy to prepare and non-toxic giving rise to useful properties as a component of a biosensor.…”

Section: Carbon-based Quantum Dots (Cqds)-based Biosensorsmentioning

confidence: 99%

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Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

Crapnell

Banks

2021

Microchim Acta

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Research into electrochemical biosensors represents a significant portion of the large interdisciplinary field of biosensing. The drive to develop reliable, sensitive, and selective biosensing platforms for key environmental and medical biomarkers is ever expanding due to the current climate. This push for the detection of vital biomarkers at lower concentrations, with increased reliability, has necessitated the utilisation of micro- and nano-dimensional materials. There is a wide variety of nanomaterials available for exploration, all having unique sets of properties that help to enhance the performance of biosensors. In recent years, a large portion of research has focussed on combining these different materials to utilise the different properties in one sensor platform. This research has allowed biosensors to reach new levels of sensitivity, but we note that there is room for improvement in the reporting of this field. Numerous examples are published that report improvements in the biosensor performance through the mixing of multiple materials, but there is little discussion presented on why each nanomaterial is chosen and whether they synergise well together to warrant the inherent increase in production time and cost. Research into micro-nano materials is vital for the continued development of improved biosensing platforms, and further exploration into understanding their individual and synergistic properties will continue to push the area forward. It will continue to provide solutions for the global sensing requirements through the development of novel materials with beneficial properties, improved incorporation strategies for the materials, the combination of synergetic materials, and the reduction in cost of production of these nanomaterials. Graphical abstract

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Section: Carbon-based Quantum Dots (Cqds)-based Biosensorsmentioning

confidence: 99%

Section: Carbon-based Quantum Dots (Cqds)-based Biosensorsmentioning

confidence: 99%

Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

Crapnell

Banks

2021

Microchim Acta

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“…Biocompatibility and imaging potential of synthesized GQDs were evaluated using MTT assay and CaSki cell lines, respectively [57]. Further, GQDs can be synthesized from fructose as a precursor in which hydrochloric acid and ethylenediamine were found to be strong chlorine and nitrogen donors for chlorine and nitrogen co-doped GQDs, respectively, which showed excellent stability [58].…”

Section: Synthetic Routes Of Gqdsmentioning

confidence: 99%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

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Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

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“…Today, humankind is faced with some diseases that are extremely difficult to cure, such as cancer. Bioimaging is a method for observing biological processes that can track cell metabolism [ 1 , 2 , 3 , 4 , 5 ]. Therefore, bioimaging technology can be used for disease detection.…”

Section: Introductionmentioning

confidence: 99%

Chlorine Modulation Fluorescent Performance of Seaweed-Derived Graphene Quantum Dots for Long-Wavelength Excitation Cell-Imaging Application

Jiang

et al. 2021

Molecules

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Biological imaging is an essential means of disease diagnosis. However, semiconductor quantum dots that are used in bioimaging applications comprise toxic metal elements that are nonbiodegradable, causing serious environmental problems. Herein, we developed a novel ecofriendly solvothermal method that uses ethanol as a solvent and doping with chlorine atoms to prepare highly fluorescent graphene quantum dots (GQDs) from seaweed. The GQDs doped with chlorine atoms exhibit high-intensity white fluorescence. Thus, their preliminary application in bioimaging has been confirmed. In addition, clear cell imaging could be performed at an excitation wavelength of 633 nm.

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Recent advances in the modification of carbon-based quantum dots for biomedical applications

Cited by 130 publications

References 212 publications

Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

Electroanalytical overview: utilising micro- and nano-dimensional sized materials in electrochemical-based biosensing platforms

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

Chlorine Modulation Fluorescent Performance of Seaweed-Derived Graphene Quantum Dots for Long-Wavelength Excitation Cell-Imaging Application

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