Recent Advances in the Investigation of Large Bowel Diseases

The present day status of colonic exfoliative cytology and the indications for the procedure when distinguishing between malignant and non‐malignant appearing ladiologic lesions are discussed here. This technique maintains an 80 to 85% diagnostic cancer accuracy rate. Certain misconceptions concerning size and location of colonic tumors, and their ability to be detected by exfoliation methods, are dispelled. The impending problem of nationwide inadequacy of gastrointestinal exfoliative units is presented in relationship to the management of patients with serologically positive blood tests for cancer and normal barium enema.

show abstract

Proliferation characteristics of human colorectal carcinomas measured in vivo

Rew

Wilson²,

Taylor

et al. 1991

Journal of British Surgery

View full text Add to dashboard Cite

The cell proliferation kinetics of 100 human colonic and rectal adenocarcinomas have been studied in vivo by bromodeoxyuridine infusion and multiparameter flow cytometry. A total of 97 patients, three with synchronous tumours, consented to receive a single bolus dose of 250 mg between 2.4 and 16 h before curative or palliative surgery. By this method, the ploidy pattern, the total and aneuploid labelling indices (LI), the S phase duration (Ts) and the potential doubling time (Tpot) can be estimated. Of the tumours 48 were diploid and 52 were aneuploid. The mean and median total LI of 100 tumours were 9.0 per cent (range 0.7-22.2 per cent). The mean aneuploid LI was 12.1 per cent (median 12.0 per cent, range 2.0-25.5 per cent), and was significantly higher than the total LI (P = 0.01). The labelling index alone is not a sufficient indicator of proliferation, because the Ts also varies within and between tumours. The intertumour range of the Ts varied from 4.0 to 28.6 h. The mean was 14.1 h and the median was 13.1 h. The mean Tpot was 5.9 days (median 3.9 days) with a range of 1.7-21.4 days. No correlation was found between any kinetic parameters and the Dukes' classification or histological classification. The correlation between proliferation and prognosis will be established in due course.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent Advances in the Investigation of Large Bowel Diseases

Cited by 6 publications

References 7 publications

Cancer of the colon and rectum.Current procedures for detection and diagnosis

Cancer of the colon and rectum.Current procedures for detection and diagnosis

Exfoliative cytology of the colon: Fifteen years of lost opportunity

Proliferation characteristics of human colorectal carcinomas measured in vivo

Contact Info

Product

Resources

About