Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers

Dextran-Sulfate-Sodium-Induced Colitis-Ameliorating Effect of Aqueous Phyllanthus emblica L. Extract through Regulating Colonic Cell Gene Expression and Gut Microbiomes

“…Class Clostridia, genus Helicobacter, and family Lachnospiraceae increased significantly in the model group compared to normal and APEH groups. Liu et al reported that Muribaculaceae was superior to other bacteria in consuming inulin, resistant starch, and polysaccharides as well as producing propionic acid. , Wang et al indicated that Muribaculaceae enhanced the production of short-chain fatty acids (SCFAs) in the administration of undigested pea protein . In the evaluation of the antiulcerative colitis effect of extracellular vesicles derived from Lactobacillus plantarum Q7, Muribaculaceae was regarded as anti-inflammatory bacteria .…”

“…49,50 Wang et al indicated that Muribaculaceae enhanced the production of short-chain fatty acids (SCFAs) in the administration of undigested pea protein. 51 In the evaluation of the antiulcerative colitis effect of extracellular vesicles derived from Lactobacillus plantarum Q7, Muribaculaceae was regarded as anti-inflammatory bacteria. 52 Previous phenotypic investigations showed that Bacteroides genus members possess extremely extensive saccharolytic potential, and some strains had the ability to target dozens of different complex glycans.…”

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

“…Exir Nano-Sina Co. (Iran) [48] developed a nano-curcumin system that could improve the stability and bioavailability of curcumin, along with improved water solubility, safety, biodistribution, and bio-compatibility. Such nanodelivery could reduce the dosage of curcumin to one-fifth of the original dose to achieve the desired anti-inflammatory effects in clinical trials.…”

“…Such an approach reduces the risk of adverse events seen in patients. Inflammation is known to be a major challenge, as it is responsible for the occurrence of several diseases [48]. Nanoscale poly (lactide-co-glycolic acid) (PLGA) particles incorporating EGCG were prepared and their response toward inflammation in human dermal fibroblasts was assessed, which showed a persistent inhibitory response compared to crude EGCG.…”

Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles

“…Most importantly, plant-and diet-derived polyphenols are considered to be beneficial to human health because they prevent the production of ROS and inhibit inflammation through various pathways. These benefits include: (1) improving the inflammatory state by inhibiting the production of inflammatory factors and inflammatory mediators, (2) improving oxidative stress by scavenging free radicals and upregulating endogenous antioxidant enzymes, and (3) acting as an antiinflammatory agent by downregulating signalling pathways such as pathways of transcription factor NF-κB and mitogenactivated protein kinase (MAPK) [25][26][27][28]. For example, gallic acid (GA), a natural secondary metabolite, is widely found in various fruits and plants and has excellent anti-inflammatory and antioxidative properties [29].…”