2003
DOI: 10.1002/chin.200338241
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Recent Advances in the Chemistry of Parainfluenza‐1 (Sendai) Virus Inhibitors

Abstract: Organic chemistryOrganic chemistry Z 0200 Recent Advances in the Chemistry of Parainfluenza-1 (Sendai) Virus Inhibitors -[132 refs.]. -(SALADINO*, R.; CIAMBECCHINI, U.; NENCIONI, L.; PALAMARA, A. T.; Med. Res. Rev. 23 (2003) 4, 427-455; Dip. Agrochim. Agrobiol., Univ. Stud. "La Tuscia", I-01100 Viterbo, Italy; Eng.) -Lindner 38-241

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“…In fact, this virus uses the surface protein HN to attach to the host cell and the F protein to be taken by the cell, upon fusion. 44 The results obtained from the analysis of cell supernatants underscored a consistent lowering in the titer of new virions released from the infected cells. The detection of HN protein by ICW on the cell monolayer revealed, a decreased expression of this protein, although not significant, when peptide treatment occurred during the ADS phase and, consequently, during ADS + POST treatment, while an increased expression level of HN was manifested during the POST phase treatment.…”
Section: Discussionmentioning
confidence: 84%
“…In fact, this virus uses the surface protein HN to attach to the host cell and the F protein to be taken by the cell, upon fusion. 44 The results obtained from the analysis of cell supernatants underscored a consistent lowering in the titer of new virions released from the infected cells. The detection of HN protein by ICW on the cell monolayer revealed, a decreased expression of this protein, although not significant, when peptide treatment occurred during the ADS phase and, consequently, during ADS + POST treatment, while an increased expression level of HN was manifested during the POST phase treatment.…”
Section: Discussionmentioning
confidence: 84%
“…Together with the successful targeting of the HIV fusion protein, this may indicate that viral fusion proteins in general could be promising targets for drug development (see also Plemper et al 2004). The different approaches for the treatment of paramyxovirus infections have been reviewed recently (Saladino et al 2003).…”
Section: Other Agentsmentioning
confidence: 99%