Recent Advances in the Chemistry and Biology of Benzothiazoles

Abstract

Benzothiazole is a privileged heterocyclic scaffold having a benzene ring fused with a five-membered thiazole ring. This moiety has attracted considerable attention because of its wide range of pharmacological activities such as antitubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, analgesic, anti-inflammatory, antidiabetic, antitumor activity, etc. In the last few years, some novel benzothiazoles have been developed with varied biological activities. To access this scaffold in high yield and to introduce diversity, a variety of new synthetic methods have been invented. In this review, we highlight the development of novel benzothiazoles for various biological activities along with the best synthetic protocols for their synthesis.

Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

“…The studies of structureactivity relationship interestingly reveals that change of the structure of substituent group at C-2 position commonly results in the change of its bioactivity. Though literature survey reports many therapeutic applications of 2-substituted benzothiazoles, their investigation for anti-inflammatory activity is limited [16,[22][23][24][25]. Furthermore, thiazole derivatives have attracted a great deal of interest due to their wide applications in the field of pharmaceuticals.…”

The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives

“…In addition, substitution of electron withdrawing groups such as amino, nitro, trifluoromethyl, and halogens especially at the 6 th position enhances the antimicrobial and antifungal activities [3][4][5][6][7][8][9][10][11][12][13] . In their literature review, Keri et.al.…”

Copper(II)- and gold(III)-mediated cyclization of a thiourea to a substituted 2-aminobenzothiazole

“…Benzothiazole derivatives can be found in nature and are a class of privileged molecules due to their biological activity and pharmaceutical applications (Gill et al, 2015). Thioureas are known to undergo intramolecular rearrangements under a variety of different conditions to form substituted 2-aminobenzothiazoles (Wang et al, 2014).…”