Copper(II)- and gold(III)-mediated cyclization of a thiourea to a substituted 2-aminobenzothiazole

Abstract

Author(s) of this paper may load this reprint on their own web site or institutional repository provided that this cover page is retained. Republication of this article or its storage in electronic databases other than as specified above is not permitted without prior permission in writing from the IUCr.For further information see http://journals.iucr.org/services/authorrights.html Acta Cryst. (2017 Benzothiazole derivatives are a class of privileged molecules due to their biological activity and pharmaceutical applications. One route to these molecules is via intramolecular cyclization of thioureas to form substituted 2-aminobenzothiazoles, but this often requires harsh conditions or employs expensive metal catalysts. Herein, the copper ( ) is required for the cyclization to proceed. As such, this study provides further mechanistic insight into the role of the metal cations in these transformations.

Synthesis, Coordination Chemistry and Anion Binding by a Cyanophenyl‐Substituted 2‐Pyridinylurea

“…Simple (thio)urea ligands with diverse potential; possible metal (M) coordination and hydrogen‐bond donor (to acceptor, A) capacities shown. L1 : X = O, A′ = CN; L2 : X = S, A′ = OCH 3 .…”