Recent advances in the applications and biotechnological production of mannitol

Dai, Yiwei; Meng, Qing Cheng; Mu, Wanmeng; Zhang, Tao

doi:10.1016/j.jff.2017.07.022

Cited by 70 publications

(40 citation statements)

References 44 publications

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“…Mannitol is abundant in essential agronomic and horticultural species [ 153 ]. Commercially available mannitol is commonly produced by industrial synthesis (i.e., hydrogenation of fructose), biosynthesis (i.e., fermentation by microorganisms, including bacteria, yeast, fungi, lichens, and algae), and natural extraction (e.g., from seaweed by Soxhlet extraction) [ 154 ].…”

Section: Resultsmentioning

confidence: 99%

Biomolecular Composition and Revenue Explained by Interactions between Extrinsic Factors and Endogenous Rhythms of Saccharina latissima

Zhang

Thomsen

2019

Marine Drugs

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This review provides a systematic overview of the spatial and temporal variations in the content of biomolecular constituents of Saccharina latissima on the basis of 34 currently-available scientific studies containing primary measurements. We demonstrate the potential revenue of seaweed production and biorefinery systems by compiling a product portfolio of high-value extract products. An investigation into the endogenous rhythms and extrinsic factors that impact the biomolecular composition of S. latissima is presented, and key performance factors for optimizing seaweed production are identified. Besides the provisioning ecosystem service, we highlight the contribution of green-engineered seaweed production systems to the mitigation of the ongoing and historical anthropogenic disturbances of the climate balance and nutrient flows. We conclude that there are risks of mismanagement, and we stress the importance and necessity of creating an adaptive ecosystem-based management framework within a triple-helix partnership for balancing the utilization of ecosystem services and long-term resilience of aquatic environment.

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Section: Resultsmentioning

confidence: 99%

Biomolecular Composition and Revenue Explained by Interactions between Extrinsic Factors and Endogenous Rhythms of Saccharina latissima

Zhang

Thomsen

2019

Marine Drugs

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“…Unlike alginate, it is a brown macroalgaederived polysaccharide without gelling and thickening properties (Kadam et al 2015a). Mannitol is a sugar alcohol which can be found in the composition of most types of plants, including algae (Dai et al 2017). In brown algae, it can reach 20-30% of d.w. (Xia et al 2015).…”

Section: Polysaccharidesmentioning

confidence: 99%

Biorefinery of marine macroalgae into high-tech bioproducts: a review

et al. 2020

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Pollution and climate change induced by fossil fuel usage are calling for the development of a circular bioeconomy based on carbon neutral resources such as marine macroalgae, also named seaweeds. Macroalgal biomass can generate biofuels and valuable bioproducts such as hydrocolloids and other unique biomolecules. Biorefinery of marine macroalgae involves a minimum use of energy and chemicals, and low waste generation, as demonstrated in recent laboratory-scale studies. Here, we review biorefinery of marine macroalgae with focus on non-energy bioproducts and advances in the separation of biomolecules. We found that metabolites with bioactive properties are in high demand for food, cosmetic, medicine and pharmaceutical industries. These metabolites can be obtained together with energy products to improve macroalgae valorization. Emerging extraction methods facilitate the generation of more qualitative bioproducts in higher yields with less energy.

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“…Mannitol (D-mannitol) is a six-carbon alditol which is naturally present in many organisms, like bacteria, yeasts, fungi, algae, lichens and several plants [1]. This polyol has numerous applications in the food and pharmaceutical industries [2][3][4]. According to Dai et al [2], the annual consumption of mannitol is approximately 150,000 t. Nowadays, mannitol is mainly produced by chemical synthesis through the hydrogenation of glucose:fructose mixtures (1:1) at high pressure and temperature using Raney nickel as a catalyst, where a mixture of 25:75 mannitol:sorbitol is obtained [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…This polyol has numerous applications in the food and pharmaceutical industries [2][3][4]. According to Dai et al [2], the annual consumption of mannitol is approximately 150,000 t. Nowadays, mannitol is mainly produced by chemical synthesis through the hydrogenation of glucose:fructose mixtures (1:1) at high pressure and temperature using Raney nickel as a catalyst, where a mixture of 25:75 mannitol:sorbitol is obtained [2][3][4][5]. The technical and economic drawbacks associated with this production route have promoted the research on alternative sources to obtain this polyol, such as extraction from brown algae and Fraxinus trees [2,4], enzymatic routes [2,5] and fermentation with various microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Mannitol bioproduction from surplus grape musts and wine lees

Hijosa‐Valsero

Garita-Cambronero

Paniagua-García

et al. 2021

LWT

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Biological mannitol production at industrial scale is hindered by the elevated costs of fructose-rich feedstocks. Grape must could be an interesting feedstock for this process, due to its large production and to the commercial imbalance caused by unsold wine stocks in producing countries. The feasibility of employing red must and white must for mannitol production was assessed with Lactobacillus fermentum CECT 285, Leuconostoc mesenteroides CECT 8146 and Lactobacillus intermedius NRRL B-3693. By means of experimental design based on response surface methodology (RSM), it was determined that nutrient supplementation could be limited to the addition of manganese and yeast extract, and that grape must should be diluted with water to improve mannitol production. Under optimal conditions, Lb. intermedius NRRL B-3693 produced 68.9 ± 0.57 g/L mannitol from red must and 79.8 ± 0.25 g/L mannitol from white must in 48 h, attaining yields of 0.888 ± 0.014 and 0.895 ± 0.001 mol/mol, respectively. In order to further reduce costs, yeast extract was replaced by wine lees. Red wine lees (RWL) performed better than white wine lees (WWL) as nitrogen source for mannitol production. Grape musts supplemented with manganese and RWL produced 59.4 ± 0.13 g/L mannitol in the case of red must and 65.6 ± 0.06 g/L mannitol in the case of white must in 144 h with Lb. intermedius NRRL B-3693. Therefore, winery surplus and by-products could be used to produce mannitol, thus opening new biorefinery opportunities for rural areas devoted to winegrowing.

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Recent advances in the applications and biotechnological production of mannitol

Cited by 70 publications

References 44 publications

Biomolecular Composition and Revenue Explained by Interactions between Extrinsic Factors and Endogenous Rhythms of Saccharina latissima

Biomolecular Composition and Revenue Explained by Interactions between Extrinsic Factors and Endogenous Rhythms of Saccharina latissima

Biorefinery of marine macroalgae into high-tech bioproducts: a review

Mannitol bioproduction from surplus grape musts and wine lees

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