Pollution and climate change induced by fossil fuel usage are calling for the development of a circular bioeconomy based on carbon neutral resources such as marine macroalgae, also named seaweeds. Macroalgal biomass can generate biofuels and valuable bioproducts such as hydrocolloids and other unique biomolecules. Biorefinery of marine macroalgae involves a minimum use of energy and chemicals, and low waste generation, as demonstrated in recent laboratory-scale studies. Here, we review biorefinery of marine macroalgae with focus on non-energy bioproducts and advances in the separation of biomolecules. We found that metabolites with bioactive properties are in high demand for food, cosmetic, medicine and pharmaceutical industries. These metabolites can be obtained together with energy products to improve macroalgae valorization. Emerging extraction methods facilitate the generation of more qualitative bioproducts in higher yields with less energy.
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