Recent Advances in Synthetic Bioelastomers

Shi, Rui; Chen, Dafu; Liu, Quanyong; Wu, Yan; Xu, Xiaochuan; Zhang, Liqun; Tian, Wei

doi:10.3390/ijms10104223

Cited by 116 publications

(75 citation statements)

References 156 publications

(136 reference statements)

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“…PUs are also non-toxic, sterilizable, non-adherent and non-allergenic [238]. Furthermore, PUs may be easily cross-linked, blended with other synthetic and/or natural-based polymers, and processed in the form of particles, fibers, films, foams and hydrogels [239]. PU-based nanofibers showed controlled evaporative water loss and promoted wound fluid drainage, which are essential characteristics for wound dressing materials [240,241].…”

Section: Polyurethanes (Pus)mentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

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Section: Polyurethanes (Pus)mentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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“…[6][7][8][9][10][11][12][13][14][15][16][17][18] In biology, understanding the flow of electrons in redox biochemistry requires understanding the relation between molecular structure and rates of charge transport. In materials science, it is important in evaluating the potential of tunneling devices based on organic matter for use in electronics: the concept of "wave-function engineering" -that is, designing and shaping tunneling barriers by molecular design -has been an influential and theoretically attractive, but practically unproven, starting point for a number of concepts proposed for molecular electronics.…”

Section: Introductionmentioning

confidence: 99%

Replacing −CH₂CH₂– with −CONH– Does Not Significantly Change Rates of Charge Transport through Ag^TS-SAM//Ga₂O₃/EGaIn Junctions

et al. 2012

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This paper describes physical-organic studies of charge transport by tunneling through self-assembled monolayers (SAMs), based on systematic variations of the structure of the molecules constituting the SAM. Replacing a −CH2CH2– group with a −CONH– group changes the dipole moment and polarizability of a portion of the molecule and has, in principle, the potential to change the rate of charge transport through the SAM. In practice, this substitution produces no significant change in the rate of charge transport across junctions of the structure AgTS-S(CH2) m X(CH2) n H//Ga2O3/EGaIn (TS = template stripped, X = −CH2CH2– or −CONH–, and EGaIn = eutectic alloy of gallium and indium). Incorporation of the amide group does, however, increase the yields of working (non-shorting) junctions (when compared to n-alkanethiolates of the same length). These results suggest that synthetic schemes that combine a thiol group on one end of a molecule with a group, R, to be tested, on the other (e.g., HS∼CONH∼R) using an amide-based coupling provide practical routes to molecules useful in studies of molecular electronics.

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“…It appears that due to its crystalline arrangements, hard segments show less accessibility to biodegradation (Umare and Chandure, 2008), hence any significant change in the elastic modulus during the degradation period was not observed. In fact some studies have reported that urethane bonds are only enzymatically degraded (Hafeman et al, 2011;Shi et al, 2009). Investigating the mass loss and molecular weight reduction during the degradation can add considerably to understanding the degradation mechanism of DegraPol®.…”

Section: Discussionmentioning

confidence: 99%

The anisotropic mechanical behaviour of electro-spun biodegradable polymer scaffolds: Experimental characterisation and constitutive formulation

Limbert

Omar

Krynauw

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Electro-spun biodegradable polymer fibrous structures exhibit anisotropic mechanical properties dependent on the degree of fibre alignment. Degradation and mechanical anisotropy need to be captured in a constitutive formulation when computational modelling is used in the development and design optimisation of such scaffolds. Biodegradable polyester-urethane scaffolds were electro-spun and underwent uniaxial tensile testing in and transverse to the direction of predominant fibre alignment before and after in vitro degradation of up to 28 days. A microstructurally-based transversely isotropic hyperelastic continuum constitutive formulation was developed and its parameters were identified from the experimental stress-strain data of the scaffolds at various stages of degradation. During scaffold degradation, maximum stress and strain in circumferential direction decreased from 1.02±0.23 MPa to 0.38±0.004 MPa and from 46±11% to 12±2%, respectively. In longitudinal direction, maximum stress and strain decreased from 0.071±0.016 MPa to 0.010±0.007 MPa and from 69±24% to 8±2%, respectively. The constitutive parameters were identified for both directions of the non-degraded and degraded scaffold for strain range varying between 0% and 16% with coefficients of determination r 2 > 0.871. The six-parameter constitutive formulation proved versatile enough to capture the varying non-linear transversely isotropic behaviour of the fibrous scaffold throughout various stages of degradation.

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Recent Advances in Synthetic Bioelastomers

Cited by 116 publications

References 156 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Replacing −CH₂CH₂– with −CONH– Does Not Significantly Change Rates of Charge Transport through Ag^TS-SAM//Ga₂O₃/EGaIn Junctions

The anisotropic mechanical behaviour of electro-spun biodegradable polymer scaffolds: Experimental characterisation and constitutive formulation

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Recent Advances in Synthetic Bioelastomers

Cited by 116 publications

References 156 publications

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Replacing −CH2CH2– with −CONH– Does Not Significantly Change Rates of Charge Transport through AgTS-SAM//Ga2O3/EGaIn Junctions

The anisotropic mechanical behaviour of electro-spun biodegradable polymer scaffolds: Experimental characterisation and constitutive formulation

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Replacing −CH₂CH₂– with −CONH– Does Not Significantly Change Rates of Charge Transport through Ag^TS-SAM//Ga₂O₃/EGaIn Junctions