2023
DOI: 10.3390/molecules28031241
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Recent Advances in Supramolecular-Macrocycle-Based Nanomaterials in Cancer Treatment

Abstract: Cancer is a severe threat to human life. Recently, various therapeutic strategies, such as chemotherapy, photodynamic therapy, and combination therapy have been extensively applied in cancer treatment. However, the clinical benefits of these therapeutics still need improvement. In recent years, supramolecular chemistry based on host–guest interactions has attracted increasing attention in biomedical applications to address these issues. In this review, we present the properties of the major macrocyclic molecul… Show more

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Cited by 7 publications
(6 citation statements)
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“…Aritharam, also known as arsenic trisulphide, has cytotoxic properties by inhibiting the development and growth of solid tumours [8]. Activity that inhibits or suppresses cell proliferation in thurusu, also known as copper sulphate, has a cytotoxic impact that hinders the growth of tumours [9]. It exerts cytotoxic effects through the induction of reactive oxygen species (ROS) production [10].…”
Section: Discussionmentioning
confidence: 99%
“…Aritharam, also known as arsenic trisulphide, has cytotoxic properties by inhibiting the development and growth of solid tumours [8]. Activity that inhibits or suppresses cell proliferation in thurusu, also known as copper sulphate, has a cytotoxic impact that hinders the growth of tumours [9]. It exerts cytotoxic effects through the induction of reactive oxygen species (ROS) production [10].…”
Section: Discussionmentioning
confidence: 99%
“…Other molecular characteristics of Cu 4 O 3 NPs, such as redox properties of Cu, generation of hydroxyl radicals, oxidation of proteins and lipids, depletion of sulfhydryls, and inhibition of dehydrogenase activity, have been reported to produce ROS 41,43 . Furthermore, due to the combined effects of GSH decrease, Cu‐associated NPs have shown to promote selective cancer cell death with minimal damage to normal cells 56 . A dose dependent, MMP depolarization was also recorded in response to Cu 4 O 3 NPs treatment (Figure 11).…”
Section: Discussionmentioning
confidence: 99%
“…Supramolecular chemistry provides a promising avenue to realize combination therapy due to the advantages of supramolecular materials, including reversibility, stimulus-response, self-healing, and modularity. Recently, macrocycle-based supramolecular biomaterials have been engaged in combination therapy. Macrocycle-based delivery systems demonstrated noteworthy advantages in precise proportional loading and synchronized release of multiple drugs. The properties are crucial for maximizing synergistic efficacy by leveraging the quantified binding constant of guest encapsulation in atomically precise cavitiesa formidable challenge for other delivery platforms. , Furthermore, host–guest complexation offers a useful strategy for ameliorating the issues of antagonism, instability, and pharmacokinetic differences among multiple drugs, which overcomes the limitations of conventional covalent modification of drugs.…”
Section: Introductionmentioning
confidence: 99%