Recent Advances in Solvent‐Free Asymmetric Catalysis

Abstract

It is well‐known that solvent is one of the most important factors that affect chemical reactions. This factor is more noticeable and impressive in the asymmetric reactions where the effective interaction of reactants and the creation of a uniform chiral environment is necessary. Nevertheless, when reactions are carried out in the absence of solvent, some privileged advantages such as easy work up, short reaction time, lack of waste solvents, and following the green chemistry principles, are appeared. Therefore, according to the importance of asymmetric synthesis and green chemistry, solvent‐free asymmetric catalysis can act as a considerable and necessary subject in synthetic chemistry. In this review, we have a survey on the solvent‐free asymmetric synthesis by the use of either homogeneous or heterogeneous chiral catalysts.

Rapid four-component synthesis of dihydropyrano[2,3-c]pyrazoles using nano-eggshell/Ti(IV) as a highly compatible natural based catalyst

“…One key-step toward green chemistry concerns on chemical transformations under solvent-free conditions [ 1 , 2 ]. Solvent free conditions often have lead to decrease reaction time, increase yields and easy work-up [ 3 , 4 ]. Combining this condition with multicomponent reactions (MCRs) disclosed a particular opportunity for architecting of heterocyclic molecules in short time [ 5 , 6 ].…”

Enabling protein-hosted organocatalytic transformations

“…Serving as a major tool for asymmetric chemical transformations, 1 – 3 organocatalysis has now matured to a point where its bio-orthogonality can be exploited for important chemical and synthetic biology applications. Catalysts such as imidazolidinone, 4 – 6 proline, 7 thiourea, 8 and anion–π 9 derivatives have been used to mediate reactions that have no parallel in nature.…”

Rapid Four-component Synthesis of Dihydropyrano[2,3-c]pyrazoles using Nano-egg Shell/Ti(IV) as a Highly Compatible Natural Based Catalyst

“…One key-step toward green chemistry concerns on chemical transformations under solvent-free conditions [1,2]. Solvent free conditions often lead to a decrease reaction time, increased yields and easy work-up [3,4]. Combining this condition with Multi-component reactions (MCRs) disclosed a particular opportunity to architecting of heterocyclic molecules in a short time [5,6].…”