Recent advances in protein-based nanoparticles and their applications in the delivery of bioactive compounds

Saif, Asifa; Anjum, Laiba; Faisal, Zargham; Akram, Noor; Shah, Yasir Abbas; Irfan, Rushba; Saeed, Farhan; Afzaal, Muhammad; Asif Shah, Mohd

doi:10.1080/10942912.2023.2261662

Cited by 5 publications

(6 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protein NPs offer the advantage of being modified with functional groups that aid in the targeted delivery of drugs and other beneficial compounds to precise sites [49]. Protein NP conjugates have been effectively employed by researchers in various applications, apart from protein NPs [50].…”

Section: Selection and Design Nanostructuresmentioning

confidence: 99%

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

Gül,

Önal Acet,

et al. 2024

IJMS

View full text Add to dashboard Cite

Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively overcome biological barriers. Smart designed/tuned nanostructures can be extremely effective for cancer treatment. The selection and design of nanostructures and the adjustment of size and surface properties are extremely important, especially for some precision treatments and drug delivery (DD). By designing specific methods, an important era can be opened in the biomedical field for personalized and precise treatment. Here, we focus on advances in the selection and design of nanostructures, as well as on how the structure and shape, size, charge, and surface properties of nanostructures in biological fluids (BFs) can be affected. We discussed the applications of specialized nanostructures in the therapy of head and neck cancer (HNC), which is a difficult and aggressive type of cancer to treat, to give an impetus for novel treatment approaches in this field. We also comprehensively touched on the shortcomings, current trends, and future perspectives when using nanostructures in the treatment of cancer.

show abstract

Section: Selection and Design Nanostructuresmentioning

confidence: 99%

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

Gül,

Önal Acet,

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Furthermore, the use of proteins as substrates for the preparation of nanoparticles as carriers of bioactive ingredients has received increased attention in the drug and food industries due to their stability, good water solubility, and bioaccessibility [111,112]. Along with applications of PBNs, which are needed to enhance the oral bioavailability from food protein NPs [113], the delivery of bioactive compounds using PBNs is a crucial issue [114,115]. Thus, the safety of PBNs and their biocompatibility as well as needed regulations were discussed in many studies focused on the rules of the US Food and Drug Administration (FDA) for approved nano-formulations.…”

Section: Protein-based Nitrogen Nanoparticlesmentioning

confidence: 99%

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Prokisch,

Törős,

Nguyen

et al. 2024

Agronomy

View full text Add to dashboard Cite

The relationship between agriculture and food is very close. It is impossible to produce adequate crops for global food security without proper farm management. Farming practices represent direct and indirect controlling factors in terms of global food security. Farming management practices influence agro-food production from seed germination through to the post-harvest treatments. Nano-farming utilizes nanotechnologies for agricultural food production. This review covers four key components of nano-farming: nano-mushroom production, protein-based nanoparticles, nano-nutrients, and nanofibers. This provides a comprehensive overview of the potential applications of nanotechnology in agriculture. The role of these components will be discussed in relation to the challenges faced and solutions required to achieve sustainable agricultural production. Edible mushrooms are important to food security because they are a nutritious food source and can produce nanoparticles that can be used in the production of other food sources. Protein-based nanoparticles have considerable potential in the delivery of bioactives as carriers and other applications. Nano-nutrients (mainly nano-selenium, nano-tellurium and carbon nanodots) have crucial impacts on the nutrient status of plant-based foods. Carbon nanodots and other carbon-based nanomaterials have the potential to influence agricultural crops positively. There are promising applications of nanofibers in food packaging, safety and processing. However, further research is needed to understand the impacts and potential risks of nanomaterials in the food production system.

show abstract

“…Inorganic particles are produced from pure metals, metal oxides, semiconductors, and ceramics, while organic particles are obtained from proteins, lipids, polymers, carbohydrates, or other organic compounds, and are divided into synthetic or natural groups. The choice of an appropriate material for nanoparticle development depends on factors such as particle size, interaction with the active compounds, desired release profile, and surface charge [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Oleandro,

Stanzione,

Buonocore

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Nanomaterials, due to their unique structural and functional features, are widely investigated for potential applications in a wide range of industrial sectors. In this context, protein-based nanoparticles, given proteins’ abundance, non-toxicity, and stability, offer a promising and sustainable methodology for encapsulation and protection, and can be used in engineered nanocarriers that are capable of releasing active compounds on demand. Zein is a plant-based protein extracted from corn, and it is biocompatible, biodegradable, and amphiphilic. Several approaches and technologies are currently involved in zein-based nanoparticle preparation, such as antisolvent precipitation, spray drying, supercritical processes, coacervation, and emulsion procedures. Thanks to their peculiar characteristics, zein-based nanoparticles are widely used as nanocarriers of active compounds in targeted application fields such as drug delivery, bioimaging, or soft tissue engineering, as reported by others. The main goal of this review is to investigate the use of zein-based nanocarriers for different advanced applications including food/food packaging, cosmetics, and agriculture, which are attracting researchers’ efforts, and to exploit the future potential development of zein NPs in the field of cultural heritage, which is still relatively unexplored. Moreover, the presented overview focuses on several preparation methods (i.e., antisolvent processes, spry drying), correlating the different analyzed methodologies to NPs’ structural and functional properties and their capability to act as carriers of bioactive compounds, both to preserve their activity and to tune their release in specific working conditions.

show abstract

Recent advances in protein-based nanoparticles and their applications in the delivery of bioactive compounds

Cited by 5 publications

References 101 publications

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Contact Info

Product

Resources

About