Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Abstract

Nanomaterials, due to their unique structural and functional features, are widely investigated for potential applications in a wide range of industrial sectors. In this context, protein-based nanoparticles, given proteins’ abundance, non-toxicity, and stability, offer a promising and sustainable methodology for encapsulation and protection, and can be used in engineered nanocarriers that are capable of releasing active compounds on demand. Zein is a plant-based protein extracted from corn, and it is biocompatible, biodegradable, and amphiphilic. Several approaches and technologies are currently involved in zein-based nanoparticle preparation, such as antisolvent precipitation, spray drying, supercritical processes, coacervation, and emulsion procedures. Thanks to their peculiar characteristics, zein-based nanoparticles are widely used as nanocarriers of active compounds in targeted application fields such as drug delivery, bioimaging, or soft tissue engineering, as reported by others. The main goal of this review is to investigate the use of zein-based nanocarriers for different advanced applications including food/food packaging, cosmetics, and agriculture, which are attracting researchers’ efforts, and to exploit the future potential development of zein NPs in the field of cultural heritage, which is still relatively unexplored. Moreover, the presented overview focuses on several preparation methods (i.e., antisolvent processes, spry drying), correlating the different analyzed methodologies to NPs’ structural and functional properties and their capability to act as carriers of bioactive compounds, both to preserve their activity and to tune their release in specific working conditions.

Research advances in Zein-based nano-delivery systems

“…In recent years, advanced materials such as micelles, liposomes, proteins, and metal nanomaterials have obvious advantages in maintaining drug stability, prolonging blood circulation time, controlling drug release, improving bioavailability, reducing toxicity, and enhancing cell absorption (5)(6)(7)(8)(9). Natural protein is promising alternatives material to traditional synthetic materials due to environment-friendliness (10,11). Besides, compared with animal protein, plant protein has received a lot of attention from researchers due to their advantages of inexpensiveness and ready accessibility (12).…”