Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications

Ozimek, Jan; Pielichowski, Krzysztof

doi:10.3390/molecules27010040

Cited by 31 publications

(21 citation statements)

References 195 publications

(256 reference statements)

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“…Polyurethanes (PUs) have found applications in many areas of everyday’s life such as foams, elastic fibers, sealants, adhesives, and varnishes. − Due to their superb toughness and flexibility, some of them are widely used as thermoplastic elastomers. Unfortunately, the conventional synthesis of PUs causes many threats to the environment and people’s health.…”

Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers

2022

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This work presents an eco-friendly synthetic pathway toward non-isocyanate poly(carbonate-urethane)s (NIPCUs) obtained from carbon dioxide and its simple derivativesorganic carbonates. Bis(hydroxyalkyl carbamate)s synthesized from ethylene carbonate and appropriate α,ω-diamines were used as polyurethane hard segment precursors while oligocarbonate diols as soft segment ones. The structures and properties of the obtained NIPCUs were explored by means of 1H NMR, 13C NMR, and FT-IR spectroscopies, MALDI-ToF mass spectrometry, DSC, and mechanical testing. Based on spectroscopic data as well as model reactions, it was demonstrated that the formation of the urea bonds was suppressed due to the presence of carbonate moieties. The reaction of urea bonds with carbonate residues led to urethane group formation. In addition, the influence of the polyurethane structure on the mechanical and thermal properties of the obtained polymers was studied. The obtained NIPCUs exhibited mechanical properties comparable to conventional polyurethane elastomers (e.g., a tensile strength of 32 MPa and an elongation at break of 800%). The described synthetic route is an straightforward way toward the replacement of conventional polyurethanes with environmentally friendly ones.

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Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers

2022

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“…The values of fail stress and elongation at break are 5–230 MPa and 200–1300%, respectively. PUs are also characterized by corrosion resistance, high gloss and weathering resistance [ 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…PUs have traditionally been used as biostable and inert materials in catheters, heart valves, prostheses, and vascular grafts [ 10 , 11 , 12 , 13 ]. However, interest in designing resorbable/degradable PUs for tissue engineering and drug delivery systems (DDSs) has also been increasing in recent years [ 10 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

Sobczak

Kędra-Królik

2022

IJMS

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With the intensive development of polymeric biomaterials in recent years, research using drug delivery systems (DDSs) has become an essential strategy for cancer therapy. Various DDSs are expected to have more advantages in anti-neoplastic effects, including easy preparation, high pharmacology efficiency, low toxicity, tumor-targeting ability, and high drug-controlled release. Polyurethanes (PUs) are a very important kind of polymers widely used in medicine, pharmacy, and biomaterial engineering. Biodegradable and non-biodegradable PUs are a significant group of these biomaterials. PUs can be synthesized by adequately selecting building blocks (a polyol, a di- or multi-isocyanate, and a chain extender) with suitable physicochemical and biological properties for applications in anti-cancer DDSs technology. Currently, there are few comprehensive reports on a summary of polyurethane DDSs (PU-DDSs) applied for tumor therapy. This study reviewed state-of-the-art PUs designed for anti-cancer PU-DDSs. We studied successful applications and prospects for further development of effective methods for obtaining PUs as biomaterials for oncology.

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“…In the last three decades, the field of POSS has developed greatly due to its well-defined nanostructures, facile chemical modification, and inexpensive precursor materials. There are a number of reviews on the synthesis of POSS compounds [ 22 , 33 , 34 , 35 ], and applications of POSS-based polymeric materials in drug delivery, photodynamic therapy, and bioimaging [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. However, we found no review on the advancement of fluorescent hybrid materials based on POSS, describing their properties and applications.…”

Section: Introductionmentioning

confidence: 99%

Design of Fluorescent Hybrid Materials Based on POSS for Sensing Applications

et al. 2022

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Polyhedral oligomeric silsesquioxane (POSS) has a nanoscale silicon core and eight organic functional groups on the surface, with sizes from 0.7 to 1.5 nm. The three-dimensional nanostructures of POSS can be used to build all types of hybrid materials with specific performance and controllable nanostructures. The applications of POSS-based fluorescent materials have spread across various fields. In particular, the employment of POSS-based fluorescent materials in sensing application can achieve high sensitivity, selectivity, and stability. As a result, POSS-based fluorescent materials are attracting increasing attention due to their fascinating vistas, including unique structural features, easy fabrication, and tunable optical properties by molecular design. Here, we summarize the current available POSS-based fluorescent materials from design to sensing applications. In the design section, we introduce synthetic strategies and structures of the functionalized POSS-based fluorescent materials, as well as photophysical properties. In the application section, the typical POSS-based fluorescent materials used for the detection of various target objects are summarized with selected examples to elaborate on their wide applications.

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Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications

Cited by 31 publications

References 195 publications

Environmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers

Environmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

Design of Fluorescent Hybrid Materials Based on POSS for Sensing Applications

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