Recent advances in polymer-coated iron oxide nanoparticles as magnetic resonance imaging contrast agents

Salehipour, Masoud; Rezaei, Shahla; Mosafer, Jafar; Parizi, Zahra Pakdin; Motaharian, Ali; Mogharabi‐Manzari, Mehdi

doi:10.1007/s11051-021-05156-x

Cited by 51 publications

(34 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the glial scar persisted 4w post-infusion of IONP and was more pronounced than after FAC infusion. One reason for this difference may be the coating material of IONPs that has a strong influence on the interaction between IONPs and biomolecules regarding the size, zeta potential, shape, and curvature (Nel et al 2009;Salehipour et al 2021). The type and coating of IONPs has already been reported to affect the distribution of IONPs after intracerebral infusion (Wang et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of Local Administration of Iron Oxide Nanoparticles in the Prefrontal Cortex, Striatum, and Hippocampus of Rats

et al. 2021

View full text Add to dashboard Cite

Iron oxide nanoparticles (IONPs) are used for diverse medical approaches, although the potential health risks, for example adverse effects on brain functions, are not fully clarified. Several in vitro studies demonstrated that the different types of brain cells are able to accumulate IONPs and reported a toxic potential for IONPs, at least for microglia. However, little information is available for the in vivo effects of direct application of IONPs into the brain over time. Therefore, we examined the cellular responses and the distribution of iron in the rat brain at different time points after local infusion of IONPs into selected brain areas. Dispersed IONPs or an equivalent amount of low molecular weight iron complex ferric ammonium citrate or vehicle were infused into the medial prefrontal cortex (mPFC), the caudate putamen (CPu), or the dorsal hippocampus (dHip). Rats were sacrificed 1 day, 1 week, or 4 weeks post-infusion and brain sections were histologically examined for treatment effects on astrocytes, microglia, and neurons. Glial scar formation was observed in the mPFC and CPu 1 week post-infusion independent of the substance and probably resulted from the infusion procedure. Compared to vehicle, IONPs did not cause any obvious additional adverse effects and no additional tissue damage, while the infusion of ferric ammonium citrate enhanced neurodegeneration in the mPFC. Results of iron staining indicate that IONPs were mainly accumulated in microglia. Our results demonstrate that local infusions of IONPs in selected brain areas do not cause any additional adverse effects or neurodegeneration compared to vehicle.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Local Administration of Iron Oxide Nanoparticles in the Prefrontal Cortex, Striatum, and Hippocampus of Rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Generally, magnetic nanoparticles (MNP) constitute a class of potent contrast agents providing positive or negative contrast depending on their concentration and on the MRI sequences used [10]. To characterize an MRI contrast agent, the relaxivities r 1 and r 2 are considered, that is, the ability of the contrast agent (normalized to the iron concentration c(Fe)) to increase the longitudinal R 1 = 1/T 1 and transversal R 2 = 1/T 2 relaxation rate of the proton magnetization.…”

Section: Introductionmentioning

confidence: 99%

Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI)

Baki

Remmo

Löwa

et al. 2021

IJMS

View full text Add to dashboard Cite

Colloidal stability of magnetic iron oxide nanoparticles (MNP) in physiological environments is crucial for their (bio)medical application. MNP are potential contrast agents for different imaging modalities such as magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Applied as a hybrid method (MRI/MPI), these are valuable tools for molecular imaging. Continuously synthesized and in-situ stabilized single-core MNP were further modified by albumin coating. Synthesizing and coating of MNP were carried out in aqueous media without using any organic solvent in a simple procedure. The additional steric stabilization with the biocompatible protein, namely bovine serum albumin (BSA), led to potential contrast agents suitable for multimodal (MRI/MPI) imaging. The colloidal stability of BSA-coated MNP was investigated in different sodium chloride concentrations (50 to 150 mM) in short- and long-term incubation (from two hours to one week) using physiochemical characterization techniques such as transmission electron microscopy (TEM) for core size and differential centrifugal sedimentation (DCS) for hydrodynamic size. Magnetic characterization such as magnetic particle spectroscopy (MPS) and nuclear magnetic resonance (NMR) measurements confirmed the successful surface modification as well as exceptional colloidal stability of the relatively large single-core MNP. For comparison, two commercially available MNP systems were investigated, MNP-clusters, the former liver contrast agent (Resovist), and single-core MNP (SHP-30) manufactured by thermal decomposition. The tailored core size, colloidal stability in a physiological environment, and magnetic performance of our MNP indicate their ability to be used as molecular magnetic contrast agents for MPI and MRI.

show abstract

“…Thus, signal intensity of T1-weighted images (positive contrast) will appear brighter and T2-weighted (negative) images will appear darker, leading to images with higher resolution. The relaxivities r1 = 1/T1 and r2 = 1/T2 are used to characterize the MNPs [18,143,144]. Ultrasmall iron oxide nanoparticles (USIO NP) were reported in various studies as T1-, T2-and dual-weighted contrast agents in in-vitro as well as in-vivo experiments [141,[145][146][147][148][149][150][151].…”

Section: Magnetic Imaging and Cell Trackingmentioning

confidence: 99%

“…However, not only the size and morphology, but also size distribution and chemical composition of the MNP core and coating are relevant characteristics [15]. Hence, specific MNP types have been designed for and utilized in a broad range of applications (Figure 1) such as diagnostic imaging [16][17][18], targeted drug delivery [19,20], magnetic fluid hyperthermia [21,22] and combined applications thereof, called theranostics [23,24]. Every application requires tailored MNPs with specific magnetic and structural properties, for which reproducible and reliable synthesis approaches to manufacture high-quality MNPs are mandatory [25].…”

Section: Introductionmentioning

confidence: 99%

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

2021

View full text Add to dashboard Cite

Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented.

show abstract

Recent advances in polymer-coated iron oxide nanoparticles as magnetic resonance imaging contrast agents

Cited by 51 publications

References 176 publications

Effects of Local Administration of Iron Oxide Nanoparticles in the Prefrontal Cortex, Striatum, and Hippocampus of Rats

Effects of Local Administration of Iron Oxide Nanoparticles in the Prefrontal Cortex, Striatum, and Hippocampus of Rats

Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI)

Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review

Contact Info

Product

Resources

About