Recent advances in pharmacotherapy for hypertriglyceridemia

Sahebkar, Amirhossein; Chew, Gerard T.; Watts, Gerald F.

doi:10.1016/j.plipres.2014.07.002

Cited by 137 publications

(75 citation statements)

References 328 publications

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“…The magnitude of this pleiotropic action of fibrates in comparison to other conventional and novel lipid-modifying treatments [63][64][65][66][67][68], including selective PPAR modulators [69,70], needs to be determined. More data from longitudinal studies are needed to assess whether the improvement in FMD may reflect a true reduction in the cardiovascular risk and if this positive effects are restricted to some particular categories of patients.…”

Section: Discussionmentioning

confidence: 99%

Fibrate therapy and flow-mediated dilation: A systematic review and meta-analysis of randomized placebo-controlled trials

Sahebkar

Giua

Pedone

et al. 2016

Pharmacological Research

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Flow-mediated dilation (FMD) of the brachial artery reflects endothelium-dependent vasodilator function; since it correlates with coronary endothelial function, its reduction could predict cardiovascular events. Several studies have investigated the potential impact of fibrates therapy on endothelial function, but clinical findings have not been fully consistent. We aimed to conduct a meta-analysis of randomized placebo-controlled trials in order to clarify whether fibrate therapy could improve endothelial function. A systematic search in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases was performed to identify randomized placebo-controlled trials investigating the effect of fibrates on endothelial function as estimated by FMD. A randomeffects model and generic inverse variance method were used for meta-analysis. Sensitivity analysis, risk of bias evaluation, and publication bias assessment were carried out using standard methods. Random-effects meta-regression was used to evaluate the impact of treatment duration on the estimated effect size. Fifteen trials with a total of 556 subjects met the eligibility criteria. Fibrate 3 therapy significantly improves FMD (weighted mean difference [WMD]: 1.64%, 95% CI: 1.15, 2.13, p < 0.001) and the result was confirmed in both subgroups with treatment durations ≤8 weeks (WMD: 1.35%, 95% CI: 0.85, 1.86, p < 0.001) and >8 weeks (WMD: 2.55%, 95% CI: 1.21, 3.89, p < 0.001). When the analysis was stratified according to the fibrate type, a significant effect was observed with fenofibrate but not with gemfibrozil, though difference between the two subgroups was not significant. Meta-analysis of data from trials where nitrate mediated dilation (NMD) was available did not suggest a significant change in NMD following treatment with fibrates. The results of this meta-analysis suggest that fibrates may exert beneficial effects on endothelial function, even over a short-term treatment course.

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Section: Discussionmentioning

confidence: 99%

Fibrate therapy and flow-mediated dilation: A systematic review and meta-analysis of randomized placebo-controlled trials

Sahebkar

Giua

Pedone

et al. 2016

Pharmacological Research

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“…NS and thymoquinone have been reported to be safe and well tolerated with no severe adverse effect. In clinical trials, NS was found to be effective when added as adjunct to standard antihyperlipidemic and antidiabetic levels and producing muscle-related adverse events in some patients [5][6][7][8][9].…”

Section: Methodsmentioning

confidence: 99%

Ameliorative effects of Nigella sativa on dyslipidemia

Asgary

Sahebkar

Goli-malekabadi

2015

J Endocrinol Invest

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“…(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) This molecule has been shown to regulate multiple transcription factors, cytokines, protein kinases, adhesion molecules, redox state enzymes and inflammatory mediators. (19)(20)(21) Interestingly, there is evidence indicating that curcumin has beneficial effects in the treatment of psychiatric disorders including anxiety (22) and depression.…”

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confidence: 99%