Recent advances in pharmaceutical applications of chiral capillary electrophoresis

Ha, Pham Thi Thanh; Hoogmartens, Jos; Schepdael, Ann Van

doi:10.1016/j.jpba.2006.01.035

Cited by 108 publications

(46 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some reviews have been published in the last years covering the chiral separation of drugs [8][9][10] or pollutants and their metabolites [11]. The aim of this review is to provide a general view of the different strategies that have been used in the last years in order to enhance the sensitivity of detection in chiral analysis by CE with application to the analysis of drugs or biological, environmental, or food samples.…”

Section: Introductionmentioning

confidence: 99%

Sensitive chiral analysis by CE: An update

et al. 2007

View full text Add to dashboard Cite

Sensitive chiral analysis by CE: An updateA general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10 210 M enabling enantiomer analysis in a variety of real samples including complex biological matrices.

show abstract

Section: Introductionmentioning

confidence: 99%

Sensitive chiral analysis by CE: An update

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Due to the vast exploration in this subject, numerous reviews detailing fundamentals and applications can be found in the literature prior to 2005 [6][7][8][9][10][11] and over the past two years [12][13][14][15]. Reviews have also covered methods developed specifically for pharmaceutical compounds [16][17][18][19][20][21][22], biological compounds [23], chiral LC-MS/ CE-MS [24], pesticides [25], pollutants [26], and food additives [27,28].…”

Section: Introductionmentioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

View full text Add to dashboard Cite

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKCThe separation of enantiomers using electrokinetic chromatography (EKC) with chiral microemulsions is comprehensively reviewed through December 1, 2006. Aqueous chiral EKC separations based on other pseudostationary phases such as micelles and vesicles or on other chiral selectors such as CDs, crown ethers, glycopeptides, ligand exchange moeities are also reviewed from both mechanistic and applications perspective for the period of

show abstract

“…Capillary electrophoresis (CE) represents an interesting alternative to HPLC for the determination of pharmaceuticals [8][9][10][11]. CE has a high-throughput, easily operable, cost-effective and an environmental friendly technique where the separation is based on differences in migration in an electric field.…”

Section: Introductionmentioning

confidence: 99%

A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography

et al. 2010

View full text Add to dashboard Cite

Abstract:A method for the fast determination of yohimbine, a potent adrenoreceptor antagonist used for the treatment of sexual dysfunctions, is proposed in this article. MEKC under basic and acidic conditions (sodium borate, pH 9.5 and sodium phosphate, pH 2.5) with SDS was developed. The effect of the experimental parameters, e.g. pH, SDS concentration and injection time, on yohimbine migration was also studied. Both methods were validated in terms of linearity, limits of detection and quantification, accuracy, and precision using caffeine as an internal standard. The application for the determination of yohimbine in hand-made medicaments is also investigated in this study. © Versita Sp. z o.o.

show abstract

Recent advances in pharmaceutical applications of chiral capillary electrophoresis

Cited by 108 publications

References 125 publications

Sensitive chiral analysis by CE: An update

Sensitive chiral analysis by CE: An update

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography

Contact Info

Product

Resources

About