Recent advances in pediatric infectious disease and their impact on dermatology

Grossman, Karyn L.; Rasnxussen, James E.

doi:10.1016/0190-9622(91)70057-9

Cited by 18 publications

(3 citation statements)

References 96 publications

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“…5 Neonates who have manifestations of congenital syphilis at birth have a poorer prognosis. 6,7 Without treatment, almost half of symptomatic infants die. 5 Erythema multiforme is an acute, self-limiting, mucocutaneous hypersensitivity reaction characterized clinically by target lesions (ie, fixed circular erythematous papules or plaques with central blistering and purpuric or necrotic change) and pathologically by necrotic keratinocytes in the epidermis and interface dermatitis.…”

mentioning

confidence: 99%

Early congenital syphilis and erythema multiforme–like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction

Tsai²,

Wong

et al. 2006

Journal of the American Academy of Dermatology

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confidence: 99%

Early congenital syphilis and erythema multiforme–like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction

Tsai²,

Wong

et al. 2006

Journal of the American Academy of Dermatology

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“…[23] Only 30% are symptomatic among the infected cases. [4] Congenital syphilis is classified into early, late and stigmata types. Early congenital syphilis refers to individuals with syphilis from the first 2 years of life.…”

Section: Discussionmentioning

confidence: 99%

Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features

Govindan

Kalaivani

2013

Indian J Sex Transm Dis

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Late congenital syphilis refers to the people with syphilis from the age of 2 to 30 years. We report a case of late congenital syphilis in a 9 year old girl with perforation of palate and saddle nose deformity. Kassowitz law was also observed (if a woman with untreated syphilis has series of pregnancies, the likelihood of infection of the fetus in later pregnancies becomes less). Venereal Disease Research Laboratory (VDRL) and Treponema pallidum hemagglutination (TPHA) were reactive. Computed tomography (CT) scan of paranasal sinus showed maxillary and nasal polyps. The case reported here is a rare presentation of late congenital syphilis with perforation of palate and saddle nose deformity.

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“…The manifestations vary; ranging from asymptomatic infection, to full blown sepsis, stillbirth, prematurity, and infant death. Of the cases of congenital syphilis reported to the Centers for Disease Control, only 30% are born with symptoms of infection, making early detection difficult (2). We present a case of congenital syphilis in a Vietnamese orphan who presents with oral rhagades and dental abnormalities upon adoption in the states.…”

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confidence: 99%

Congenital Syphilis: Early‐ and Late‐Stage Findings of Rhagades and Dental Anomalies

Khetarpal

Mostow

2010

Pediatric Dermatology

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Congenital syphilis occurs via vertical transmission when Treponema pallidum crosses the placenta after the 16th week of gestation. Manifestations of congenital syphilis vary from asymptomatic infection to stillbirth. We present a case of congenital syphilis in a Vietnamese orphan who presented with rhagades, hearing deficit, and abnormal dentition after adoption in the United States. He demonstrated both early- and late-stage findings of congenital syphilis. He is presumed to be 5 years old, and it is uncertain if he received treatment. Upon arrival to the United States, his rapid plasma reagin test was negative, but his fluorescent treponemal antibody-absorption test was positive, so no further treatment was recommended. It is possible that other late congenital syphilis stigmata may develop in his later years. The Centers for Disease Control recommends screening all pregnant women for syphilis at the beginning of prenatal care. Clinicians should be made aware of the manifestations of congenital syphilis, especially when caring for international orphans and children born to mothers who lacked prenatal care.

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Recent advances in pediatric infectious disease and their impact on dermatology

Cited by 18 publications

References 96 publications

Early congenital syphilis and erythema multiforme–like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction

Early congenital syphilis and erythema multiforme–like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction

Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features

Congenital Syphilis: Early‐ and Late‐Stage Findings of Rhagades and Dental Anomalies

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