Congenital Syphilis: Early‐ and Late‐Stage Findings of Rhagades and Dental Anomalies

Khetarpal, B S Shilpi; E, Kempf; Mostow, M.P.H. Eliot

doi:10.1111/j.1525-1470.2010.01288.x

Cited by 12 publications

(10 citation statements)

References 4 publications

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“…Manifestations of congenital syphilis vary from asympto-matic infection to stillbirth 1. Mucocutaneous manifestations occur in 15–60% of infected infants 2…”

mentioning

confidence: 99%

Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas

Tana¹,

Lio²,

Vento³

2012

Arch Dis Child Fetal Neonatal Ed

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Images in neonatal medicine Images in neonatal medicineEarly congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areasThe illustrated infant was birthed by an emergency caesarean section owing to placental abruption at 35 weeks of gestational age. The mother was serologically negative for relevant infections, except for a weakly-reactive Venereal Disease Research Laboratory (VDRL) test at the time of delivery.Examination of the newborn revealed multiple widespread vesicular bullous eruption involving the back of hands and feet, some of which were already broken leaving a denuded and macerated area (fi gure 1). Also found were annular maculopapular lesions on the anterior surface of the thorax and abdomen, hepatosplenomegaly with elevated direct bilirubin, anaemia and leukaemoid blood picture.Haematology revealed serum positive for enzyme immunoassay for treponemal immunoglobulin M, Treponema Pallidum Haemagglutination (1/5120) and VDRL (1/64). The cerebrospinal fl uid VDRL test was negative.A diagnosis of early congenital syphilis was made and was treated with parenteral penicillin G. The newborn showed improvement in the clinical conditions following treatment until discharge.Manifestations of congenital syphilis vary from asymptomatic infection to stillbirth. 1 Mucocutaneous manifestations occur in 15-60% of infected infants. 2 In this case there was the typical early pemphigus syphiliticus, usually affecting palms and soles, 2-4 involving atypical skin areas whereby highlighting how varied and severe the signs of congenital syphilis can be, and the consequent need for the doctors to be aware of this condition since an early and appropriate treatment can produce a good outcome. 5 REFERENCES1. Khetarpal S, Kempf E, Mostow E. Congenital syphilis: early-and late-stage fi ndings of rhagades and dental anomalies. Pediatr Dermatol 2011;28:401-3. 2. Remington JS, Klein JO. Infectious disease of the fetus and newborn. Fifth edition. Philadelphia: WB Saunders 2001;12:643-81. 3. Liu CC, So WC, Lin CH, et al. Congenital syphilis: clinical manifestations in premature infants. Scand J Infect Dis 1993;25:741-5. 4. Chawla V, Pandit PB, Nkrumah FK. Congenital syphilis in the newborn. Arch Dis Child Fetal Neonatal Ed 2012;97:F471.

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“…Manifestations of congenital syphilis vary from asympto-matic infection to stillbirth 1. Mucocutaneous manifestations occur in 15–60% of infected infants 2…”

mentioning

confidence: 99%

Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas

Tana¹,

Lio²,

Vento³

2012

Arch Dis Child Fetal Neonatal Ed

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“…6 A discussion of berries in the mouth is incomplete without the toothsome mulberry molars of congenital syphilis. 7 Glossitis, seen in nutritional deficiencies, infections, and infiltrative processes, is often described as a beefy red tongue. 8 Ironically, beef can prove therapeutic for B-vitamin or iron deficiency.…”

Section: Oral Cavitymentioning

confidence: 99%

Diagnostic Utility of Food Terminology: Culinary Clues for the Astute Diagnostician

Mark

Lessing

Buckley

et al. 2015

The American Journal of Medicine

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“…This bacterium can be transmitted during vaginal, anal, or oral sex (analingus, cunnilingus, and fellatio). Pregnant women with syphilis may also transmit it transplacentally or during birth to the fetus [11], leading to malformations of the skin, mucous membranes, skeletal, eye, liver, kidney, and central nervous system. The congenital disease gives rise to Hutchinson's triad dental abnormalities, deafness, and eye damage, as well as bone, skin, and neurological anomalies of the face [11].…”

Section: Syphilismentioning

confidence: 99%

Transmission of Nonviral Sexually Transmitted Infections and Oral Sex

Ballini

Cantore

Fatone

et al. 2012

The Journal of Sexual Medicine

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Introduction Oral sex is usually considered a lower-risk sexual activity when compared with sex, but it is frequently the cause of sexually transmitted infections (STI). In particular, STI transferred through oral sex might have no visible symptoms, depending on the type of infection. Aims The aim of this study is to review the literature about the role of oral sex in the transmission of nonviral STI. Main Outcome Measures State-of-the-art information in the area of STI in relation to sexual function and self–care, this last important for development of STI prevention products such as vaginal microbicides. Sexual behaviors assessed focusing on receiving oral sex and giving oral sex. Methods A search of the main electronic databases including registers of clinical controlled trials was performed in addition to a hand search of the most relevant Journals. The following electronic databases were searched: PubMed, Embase, Google Scholar, literature review of research articles, and public health department Internet Web sites, for the period of 1945–2011. In addition to searching the Clinical Trials Registry at the US National Institutes of Health, we also used the meta Register of Controlled Trials and the Cochrane Central Register of Controlled Trials. Results STI affect the mucous membranes both directly and indirectly producing characteristic diagnostic signs and lesions. Daily dental clinical activity needs an appropriate knowledge of any kind of oral lesions-related STI. The reader is offered a practical approach with clinically relevant recommendations that may prove useful in his/her daily practice when dealing with STI. Conclusions These data provide a foundation for understanding diverse STI. We advise physicians to be receptive to discuss sexuality issues and provide patients with adequate therapy.

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Congenital Syphilis: Early‐ and Late‐Stage Findings of Rhagades and Dental Anomalies

Cited by 12 publications

References 4 publications

Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas

Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas

Diagnostic Utility of Food Terminology: Culinary Clues for the Astute Diagnostician

Transmission of Nonviral Sexually Transmitted Infections and Oral Sex

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