Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology

Herrington, C. Simon; Poulsom, Richard; Coates, Philip J.

doi:10.1002/path.5255

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…To better understand the cancerized field and its implication for breast cancer, researchers need to explore beyond the boundaries of traditional methods. Novel lines of evidence point towards the benefits of integrating molecular pathology and epidemiologytermed molecular pathological epidemiologyto enable researchers to link factors such as environmental exposures and host genetics to pathologic features [86][87][88][89][90][91].…”

Section: The Added Value Of Molecular Pathological Epidemiologymentioning

confidence: 99%

Field cancerization in breast cancer

Gadaleta

Thorn

Ross-Adams

et al. 2022

The Journal of Pathology

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Breast cancer affects one in seven women worldwide during their lifetime. Widespread mammographic screening programs and education campaigns allow for early detection of the disease, often during its asymptomatic phase. Current practice in treatment and recurrence monitoring is based primarily on pathological evaluations but can also encompass genomic evaluations, both of which focus on the primary tumor. Although breast cancer is one of the most studied cancers, patients still recur at a rate of up to 15% within the first 10 years post‐surgery. Local recurrence was originally attributed to tumor cells contaminating histologically normal (HN) tissues beyond the surgical margin, but advances in technology have allowed for the identification of distinct aberrations that exist in the peri‐tumoral tissues themselves. One leading theory to explain this phenomenon is the field cancerization theory. Under this hypothesis, tumors arise from a field of molecularly altered cells that create a permissive environment for malignant evolution, which can occur with or without morphological changes. The traditional histopathology paradigm dictates that molecular alterations are reflected in the tissue phenotype. However, the spectrum of inter‐patient variability of normal breast tissue may obfuscate recognition of a cancerized field during routine diagnostics. In this review, we explore the concept of field cancerization focusing on HN peri‐tumoral tissues: we present the pathological and molecular features of field cancerization within these tissues and discuss how the use of peri‐tumoral tissues can affect research. Our observations suggest that pathological and molecular evaluations could be used synergistically to assess risk and guide the therapeutic management of patients. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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Section: The Added Value Of Molecular Pathological Epidemiologymentioning

confidence: 99%

Field cancerization in breast cancer

Gadaleta

Thorn

Ross-Adams

et al. 2022

The Journal of Pathology

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“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are leading causes of death (30% to 60%) in patients with sepsis (Cecconi et al, 2018;Fan et al, 2018;Matthay et al, 2019). Both ALI and ARDS are characterized by diffuse alveolar damage and increased alveolar capillary permeability (Herrington et al, 2019). Evidence indicates that thrombosis and coagulopathy are major contributors to ALI and ARDS (Helms et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

Zhang

Zhou

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundPatients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury remains elusive. The aim of this study was to investigate the role of tissue factor-enriched NETs in the progression and immunothrombosis of sepsis-induced lung injury.MethodsHuman blood samples and an animal model of sepsis-induced lung injury were used to detect and evaluate NET formation in ARDS patients. Immunofluorescence imaging, ELISA, Western blotting, and qPCR were performed to evaluate in vitro NET formation and tissue factor (TF) delivery ability. DNase, an anti-TF antibody, and thrombin inhibitors were applied to evaluate the contribution of thrombin to TF-enriched NET formation and the contribution of TF-enriched NETs to immunothrombosis in ARDS patients.ResultsSignificantly increased levels of TF-enriched NETs were observed in ARDS patients and mice. Blockade of NETs in ARDS mice alleviated disease progression, indicating a reduced lung wet/dry ratio and PaO2 level. In vitro data demonstrated that thrombin-activated platelets were responsible for increased NET formation and related TF exposure and subsequent immunothrombosis in ARDS patients.ConclusionThe interaction of thrombin-activated platelets with PMNs in ARDS patients results in local NET formation and delivery of active TF. The notion that NETs represent a mechanism by which PMNs release thrombogenic signals during thrombosis may offer novel therapeutic targets.

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“…Through in silico analysis, 17 genes that were putatively associated with the three miRNAs (miR-4535, miR-1915-5p and miR-191-5p) were selected. Of these, CD44, KDM1B, FKBP4, TEF, SYT4, SATB1 and PLCD1 are reported to be involved in the inflammatory reaction [76][77][78][79][80][81][82]; for the remaining ten genes, there have been no reports concerning inflammation or infection. In principle, CD44 and SYT4 are membrane proteins, and the other molecules are nuclear proteins or transcriptional factors.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs miR-4535 and miR-1915-5p in Amniotic Fluid As Predictive Biomarkers for Chorioamnionitis

et al. 2021

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Background: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. Materials & methods: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc’s criteria. Results: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation. Conclusion: miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.

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Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology

Cited by 14 publications

References 15 publications

Field cancerization in breast cancer

Field cancerization in breast cancer

Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury

MicroRNAs miR-4535 and miR-1915-5p in Amniotic Fluid As Predictive Biomarkers for Chorioamnionitis

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