Recent Advances in Palladium‐Based Cross‐Dehydrogenative‐Coupling (CDC) with C(sp ² )H/C(sp ² )H Bond to Form New C(sp ² )C(sp ² ) Bond

Abstract

The advancement of CH/CH cross‐dehydrogenative coupling (CDC) reactions for the construction of C(sp 2 )C(sp 2 ) bond with representative examples from mainly 2016 to May 2021 is overviewed. Palladium‐catalyzed CDC reaction has been considered as a modern and attractive synthetic tool due to (i) limited amount of undesired and toxic by‐products; (ii) more straightforward synthetic approach from simple materials, resulting in a better step‐ and atom economy. Diversified applications across pharmaceutical and material areas have been successfully realized. In addition to the ordinary CDC reaction, the most recent accomplishments of asymmetric CDC process are also included.

Cross‐Dehydrogenative Coupling Polymerization via C−H Activation for the Synthesis of Conjugated Polymers

“…This twofold CÀ H functionalization strategy has been comprehensively demonstrated in small molecule transformations for more than a decade now, which have been documented in various review articles. [35][36][37][38][39][40][41] It has found application in the synthesis of natural products and pharmaceuticals. [42,43] Direct crosscoupling of two different π-monomeric units without any prefunctionalization of their CÀ H bonds is presumably an ideal way of constructing π-conjugated alternating copolymers including donor-acceptor polymers, where transition metal-catalyzed cross-dehydrogenative coupling polymerization comes into play (Scheme 1c).…”