With a tandem DMAP-catalyzed reaction
between o-AQM, in which it is generated in situ from
propargylic amine, and
acyl carbene surrogate (from pyridinium ylide), a variety of polyarylated
chromenes are assembled in good yields. This process does not require
transition-metal catalyst and exhibits easy manipulation of the arene
group and good functional group compatibility, particularly the −Br
group which can be further transformed to other functionalities by
cross-coupling reactions. The modular feature of o-AQM substrates and the simple operation procedures add further advantages
to this synthetic method.
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