Recent advances in nanomedicine preparative methods and their therapeutic potential for colorectal cancer: a critical review

Abstract

Colorectal cancer (CRC) is a prevalent malignancy that affects a large percentage of the global population. The conventional treatments for CRC have a number of limitations. Nanoparticles have emerged as a promising cancer treatment method due to their ability to directly target cancer cells and regulate drug release, thereby enhancing therapeutic efficacy and minimizing side effects. This compilation examines the use of nanoparticles as drug delivery systems for CRC treatment. Different nanomaterials can be used to administer anticancer drugs, including polymeric nanoparticles, gold nanoparticles, liposomes, and solid lipid nanoparticles. In addition, we discuss recent developments in nanoparticle preparation techniques, such as solvent evaporation, salting-out, ion gelation, and nanoprecipitation. These methods have demonstrated high efficacy in penetrating epithelial cells, a prerequisite for effective drug delivery. This article focuses on the various targeting mechanisms utilized by CRC-targeted nanoparticles and their recent advancements in this field. In addition, the review offers descriptive information regarding numerous nano-preparative procedures for colorectal cancer treatments. We also discuss the outlook for innovative therapeutic techniques in the management of CRC, including the potential application of nanoparticles for targeted drug delivery. The review concludes with a discussion of current nanotechnology patents and clinical studies used to target and diagnose CRC. The results of this investigation suggest that nanoparticles have great potential as a method of drug delivery for the treatment of colorectal cancer.

Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

“…Other more recent treatment modalities, such as immunotherapy and targeted therapy, achieved high degree of success [ 72 , 73 ]. Targeted therapies, such as liposomes, niosomes, polymeric nanoparticles, micelles, gold nanoparticles, and other colloidal carriers, can be used as drug delivery systems for colorectal cancer [ 74 , 75 , 76 ].…”

Smart Tissue Carriers for Innovative Cosmeceuticals and Nutraceuticals

“…Consequently, and according to consumer requests, the discussed proposal of using novel tissue-based carriers to realize innovative, effective and safe cosmeceuticals and nutraceuticals seems to be moving in the right direction [104][105][106][107]. The proposed nanostructured tissue, in fact, is able to ameliorate the active ingredients' penetration by overcoming the skin and mucous membrane barriers, and it has been shown to be human health and environmentally friendly since it is also packaged in biodegradable containers [106][107][108][109][110]. In addition, these innovative structures, which are free of water, preservatives, emulsifiers, fragrances, colors and other chemicals, might reduce the consumption of water and could therefore avoid certain allergic and sensitization skin phenomena when used as a substitution of current cosmetic emulsions.…”