Recent Advances in Nanomaterial Probes for Optical Biothiol Sensing: A Review

Tsogas, George Z.; Kappi, Foteini A.; Vlessidis, Athanasios G.; Giokas, Dimosthenis L.

doi:10.1080/00032719.2017.1329833

Cited by 38 publications

(19 citation statements)

References 92 publications

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“…5 b(2)) 47 – 49 . As shown in Table 1 , the concentration of biothiols in the human serum was determined to be 144 µM, which is in good agreement with the previous reports 5 , 45 . Furthermore, we confirmed that this method is highly robust and reproducible as evidenced by the good recovery rate ranging from 94.4 to 108.7% and the low coefficient of variation (CV) less than 8%.…”

Section: Resultssupporting

confidence: 91%

“…The determination of sulfur-containing amino acids such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH) in human serum is important because the level of total biothiols can serve as the biomarker for predicting survival rates in oral cancer patients 1 , and monitoring oxidative stress in patients with nonalcoholic steatohepatitis 2 and acute appendicitis 3 , 4 . Furthermore, the determination of individual biothiols is also required since each plays a vital role in the clinical diagnosis of many disorders and diseases 5 . For example, decreased Hcy levels in plasma are useful for the diagnosis of homocystinuria 6 , while the elevated Hcy levels in plasma can be a risk factor for osteoporosis 7 , Alzheimer’s disease 8 , occlusive vascular diseases 9 , 10 , cardiovascular diseases 11 , 12 , neural tube defects 13 , and lung cancer 14 .…”

Section: Introductionmentioning

confidence: 99%

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Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

Lee

Kim

et al. 2021

Sci Rep

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We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface of AgNPRs through Ag–S covalent interactions protect the AgNPRs from being etched by chloride ion (Cl−) in human serum, thus exhibiting the blue/purple color that is indicative of AgNPRs. On the other hand, the color of AgNPRs turned to yellow in the absence of biothiols or the presence of non-sulfur-containing amino acids, indicating the formation of small silver nanoparticles (AgNPs). Importantly, we found that individual biothiols (Hcy, Cys, and GSH) exert not only the anti-etching effect, but also the aggregating effect on AgNPRs, which can be modulated by simply tuning the pH conditions, and this consequently allows for the discriminative detection of each biothiol. Based on this simple and cost-effective strategy, we successfully determined the Hcy, Cys, and GSH in human serum with high sensitivity and selectivity within 10 min, demonstrating the diagnostic capability and potential in practical applications.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

Lee

Kim

et al. 2021

Sci Rep

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“…Over the past years, quantification on the basis of NPs has been largely developed to evaluate GSH in intracellular and/or extracellular concentrations in various biological matrices such as plasma, urine or saliva. Many colorimetric methods using gold NPs (AuNPs) (sensor or probes) [ 81 ] have been developed on the basis of their high molar absorbance coefficient associated with a specific plasmonic resonance-band shift (the maximum wavelength moves from a dispersed to an aggregated state or vice versa; see, e.g., [ 82 ]). The development of such nanosystems is very interesting but can lead to many problems of interference as a result, in particular, of chemical structures close to glutathione in large quantities in the body, such as cysteine or homocysteine [ 83 ].…”

Section: Methodologies For Dosage Of Glutathione/glutathiolated Prmentioning

confidence: 99%

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

et al. 2018

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Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery. After recalling the biochemistry of GSH, including its metabolism pathways and redox properties, its involvement in cellular redox homeostasis and signaling is described. Analytical methods for the dosage and localization of GSH or glutathiolated proteins are also covered. Finally, the various therapeutic strategies to replenish GSH stocks are discussed, in parallel with its use as an addressing molecule in drug delivery.

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“…In cross-linking methods, the target compound and ligand on the gold nanoparticle surface form a complex, which decreases the interparticle distance and causes aggregation [95]. This method requires nanoparticle modification with specific ligands.…”

Section: Principle Of Gold Nanoparticles-based Colorimetric Sensormentioning

confidence: 99%

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

Liu

Huang

et al. 2018

Sensors

155

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Due to their unique optical properties, narrow size distributions, and good biological affinity, gold nanoparticles have been widely applied in sensing analysis, catalytic, environmental monitoring, and disease therapy. The color of a gold nanoparticle solution and its maximum characteristic absorption wavelength will change with the particle size and inter-particle spacing. These properties are often used in the detection of hazardous chemicals, such as pesticide residues, heavy metals, banned additives, and biotoxins, in food. Because the gold nanoparticles-colorimetric sensing strategy is simple, quick, and sensitive, this method has extensive applications in real-time on-site monitoring and rapid testing of food quality and safety. Herein, we review the preparation methods, functional modification, photochemical properties, and applications of gold nanoparticle sensors in rapid testing. In addition, we elaborate on the colorimetric sensing mechanisms. Finally, we discuss the advantages and disadvantages of colorimetric sensors based on gold nanoparticles, and directions for future development.

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Recent Advances in Nanomaterial Probes for Optical Biothiol Sensing: A Review

Cited by 38 publications

References 92 publications

Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

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