Recent Advances in Nanobiotechnology and High-Throughput Molecular Techniques for Systems Biomedicine

Kim, Eung Sam; Ahn, Eun Hyun; Chung, Euiheon; Kim, Deok Ho

doi:10.1007/s10059-013-0304-6

Cited by 11 publications

(8 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanotechnology is the design, description, implementation, manufacturing, methods, and devices of structures by the shape and volume of the nanometer range [21]. To inspect or regulate biological procedures [22]. With completely new features and functions acquired from their 100 nm domain volume.…”

Section: Introductionmentioning

confidence: 99%

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

AL-Ahmari

El-Hamidy

2021

JPRI

View full text Add to dashboard Cite

Aim: This investigation pointed to estimate skeletal muscle efficiency of diamond nanoparticles in enhancing Vinblastine (VBL) effects. Methodology: One hundred Albino mice, weighing (23- 28 grams) were utilized in this research, after a week of habituation, the mice were divided into five groups at random (20 mice each). Group 1 (control) obtained distilled water infusions, Group 2 (ESC group) injected Ehrlich cells via intramuscular infusion (IM), and Group 3 (ESC+VBL group) gained Vinblastine only, Group 4 (ESC+VBL+ND) received an IM injection of Vinblastine loaded on diamond nanoparticles and Group 5 (ESC+VBL+CS+ND) received IM administration of Vinblastine stacked on Chitosan with nanodiamond. Finally, blood specimens were taken. Serum was obtained to measure Asparaginase aminotransferase, Alanine aminotransferase, and Creatinine kinase. The muscle was removed and observed under a light microscope. Results: Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Creatinine kinase levels in the blood were elevated in ESC than in normal and treated groups. Levels of these enzymes were enhanced after treatment of VBL, diamond nanoparticles and chitosan. Conclusion: Nanodiamond are influenced in the VBL delivery system for the therapy of Ehrlich Solid carcinoma in mice models. The embattled VBL liberates tumor cells and reduced the side effect of VBL on skeletal muscle.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

AL-Ahmari

El-Hamidy

2021

JPRI

View full text Add to dashboard Cite

show abstract

“…Small effects of non-coding variants on regulatory functions could be ignored if analysis is not performed on systematic level. Systematic analysis and multi-scale modeling of coding variants by integrating tissue-specific gene-gene interactions or protein-protein interactions is proven fruitful [3–6]. …”

Section: Introductionmentioning

confidence: 99%

VariFunNet, an integrated multiscale modeling framework to study the effects of rare non-coding variants in genome-wide association studies: Applied to Alzheimer's disease

Chen

Gao

et al. 2017

2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

View full text Add to dashboard Cite

It is a grand challenge to reveal the causal effects of DNA variants in complex phenotypes. Although statistical techniques can establish correlations between genotypes and phenotypes in Genome-Wide Association Studies (GWAS), they often fail when the variant is rare. The emerging Network-based Association Studies aim to address this shortcoming in statistical analysis, but are mainly applied to coding variations. Increasing evidences suggest that non-coding variants play critical roles in the etiology of complex diseases. However, few computational tools are available to study the effect of rare non-coding variants on phenotypes. Here we have developed a multiscale modeling variant-to-function-to-network framework VariFunNet to address these challenges. VariFunNet first predict the functional variations of molecular interactions, which result from the non-coding variants. Then we incorporate the genes associated with the functional variation into a tissue-specific gene network, and identify subnetworks that transmit the functional variation to molecular phenotypes. Finally, we quantify the functional implication of the subnetwork, and prioritize the association of the non-coding variants with the phenotype. We have applied VariFunNet to investigating the causal effect of rare non-coding variants on Alzheimer’s disease (AD). Among top 21 ranked causal non-coding variants, 16 of them are directly supported by existing evidences. The remaining 5 novel variants dysregulate multiple downstream biological processes, all of which are associated with the pathology of AD. Furthermore, we propose potential new drug targets that may modulate diverse pathways responsible for AD. These findings may shed new light on discovering new biomarkers and therapies for the prevention, diagnosis, and treatment of AD. Our results suggest that multiscale modeling is a potentially powerful approach to studying causal genotype-phenotype associations.

show abstract

“…It is applied in many fields including electronics, information technology, material developments and biomedicine ( 3 ). Nanobiotechnology represents a specific category of nanotechnology, based on biological molecules and processes that involve the creation of devices and systems at the nanolevel to examine or control biological processes ( 4 , 5 ).…”

Section: Introduction To Nanotechnologymentioning

confidence: 99%

Nanotechnology applications in hematological malignancies (Review)

et al. 2015

View full text Add to dashboard Cite

A major limitation to current cancer therapies is the development of therapy-related side-effects and dose limiting complications. Moreover, a better understanding of the biology of cancer cells and the mechanisms of resistance to therapy is rapidly developing. The translation of advanced knowledge and discoveries achieved at the molecular level must be supported by advanced diagnostic, therapeutic and delivery technologies to translate these discoveries into useful tools that are essential in achieving progress in the war against cancer. Nanotechnology can play an essential role in this aspect providing a transforming technology that can translate the basic and clinical findings into novel diagnostic, therapeutic and preventive tools useful in different types of cancer. Hematological malignancies represent a specific class of cancer, which attracts special attention in the applications of nanotechnology for cancer diagnosis and treatment. The aim of the present review is to elucidate the emerging applications of nanotechnology in cancer management and describe the potentials of nanotechnology in changing the key fundamental aspects of hematological malignancy diagnosis, treatment and follow-up.

show abstract

Recent Advances in Nanobiotechnology and High-Throughput Molecular Techniques for Systems Biomedicine

Cited by 11 publications

References 79 publications

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

VariFunNet, an integrated multiscale modeling framework to study the effects of rare non-coding variants in genome-wide association studies: Applied to Alzheimer's disease

Nanotechnology applications in hematological malignancies (Review)

Contact Info

Product

Resources

About