Recent Advances in Mercury Research

Martinez-Finley, Ebany J.; Aschner, Michael

doi:10.1007/s40572-014-0014-z

Cited by 50 publications

(19 citation statements)

References 40 publications

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“…Mercury caused more destructions in cell metabolism than recovery by Nano gold [11]. Nano gold was used for neurotoxic recovery that is caused by mercury [12]. This computation supports the fact that the volunteer face skin condition that has recovered after 4 weeks is near normal condition.…”

Section: Resultssupporting

confidence: 55%

The Clinical Test of Nano gold Cosmetic for Recovering Skin Damage Due to Chemicals: Special Case

Taufikurohmah

Wardana

Tjahjani

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. Manufacturing of Nano gold cosmetics was done at PT. Gizi Indonesia. Clinical trials to cosmetics data supported that cosmetics are able to treat skin health which has been reported partially. For special cases, the recovery process of facial skin damage should also receive attention including cases of facial skin damage caused by chemicals such as phenol, HCl, aqua regia or other harsh chemicals. The problem determined whether the Nano gold is able to recover skin damage due to the harsh chemicals. This clinical trial data on the forms of early skin damage caused by phenol was delivered in the forms of facial photos patients. The recovery progress of facial skin condition was obtained every week for two months. The data included the forms of widespread wounds during the recovery process. This statement supported by anova statistical analysis of the widespread wound changing every week for 8 times. The conclusion is skin damage due to Phenol impregnation can be recovered with the use of Nano gold cosmetics for 8 weeks. This results support the manufacturing of Nano gold cosmetics for the needs of society. It also suggest that Nano gold material can be used for medicine manufacturing in the future.

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Section: Resultssupporting

confidence: 55%

The Clinical Test of Nano gold Cosmetic for Recovering Skin Damage Due to Chemicals: Special Case

Taufikurohmah

Wardana

Tjahjani

et al. 2018

J. Phys.: Conf. Ser.

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“…Although the experiments were performed using only two MeHg concentrations, linear-type kinetics observed in the accumulation reflects a diffusive accumulation of this metal from the extracellular medium. The presence of organic grouping methyl associated with Hg gives this metal this diffuse ability through biological/cellular membranes due to its lipophilic characteristic [30].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Nogueira

Vasconcelos

Mitre

et al. 2019

Oxidative Medicine and Cellular Longevity

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Human exposure to mercury (Hg) is primary associated with its organic form, methylmercury (MeHg), through the ingestion of contaminated seafood. However, Hg contamination is also positively correlated with the number of dental restorations, total surface of amalgam, and organic mercury concentration in the saliva. Among the cells existing in the oral cavity, human periodontal ligament fibroblast (hPLF) cells are important cells responsible for the production of matrix and extracellular collagen, besides sustentation, renewal, repair, and tissue regeneration. In this way, the present study is aimed at investigating the potential oxidative effects caused by MeHg on hPLF. Firstly, we analyzed the cytotoxic effects of MeHg (general metabolism status, cell viability, and mercury accumulation) followed by the parameters related to oxidative stress (total antioxidant capacity, GSH levels, and DNA damage). Our results demonstrated that MeHg toxicity increased in accordance with the rise of MeHg concentration in the exposure solutions (1-7 μM) causing 100% of cell death at 7 μM MeHg exposure. The general metabolism status was firstly affected by 2 μM MeHg exposure (43.8 ± 1.7%), while a significant decrease of cell viability has arisen significantly only at 3 μM MeHg exposure (68.7 ± 1.4%). The ratio among these two analyses (named fold change) demonstrated viable hPLF with compromised cellular machinery along with the range of MeHg exposure. Subsequently, two distinct MeHg concentrations (0.3 and 3 μM) were chosen based on LC50 value (4.2 μM). hPLF exposed to these two MeHg concentrations showed an intracellular Hg accumulation as a linear-type saturation curve indicating that metal accumulated diffusively in the cells, typical for metal organic forms such as methyl. The levels of total GSH decreased 50% at exposure to 3 μM MeHg when compared to control. Finally, no alteration in the DNA integrity was observed at 0.3 μM MeHg exposure, but 3 μM MeHg caused significant damage. In conclusion, it was observed that MeHg exposure affected the general metabolism status of hPLF with no necessary decrease on the cell death. Additionally, although the oxidative imbalance in the hPLF was confirmed only at 3 μM MeHg through the increase of total GSH level and DNA damage, the lower concentration of MeHg used (0.3 μM) requires attention since the intracellular mercury accumulation may be toxic at chronic exposures.

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“…Years of experimental works have shown Hg 2+ to pose health problems not only to human beings but also to other animal species. Hg 2+ contamination is being engendered through natural and anthropogenic endeavours, including ocean and volcanic eruptions, mining of metal (especially artisanal and small-scale gold mining, ASGM), incineration of waste, tanning of leather, electroplating, occupational operations, dental care, preventive medical practices, agricultural and industrial operations, and fossil fuel combustion (from coal-burning power plants) (Renzoni et al 1998;Rice et al 2014;Bravo et al 2014;Costa et al 2016;Martinez-Finley et al 2014). Elemental mercury and ionic mercury (Hg and Hg 2+ , respectively) have the tendency to be transformed by microorganisms like bacteria into methylmercury (MeHg), which is a potentially harmful neurotoxin capable of bioaccumulation into the food chain (Nolan and Lippard 2008).…”

Section: Mercury (Ii) (Hg 2+ ) Detectionmentioning

confidence: 99%

Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

Aderinto

2020

Chem. Pap.

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Though it has not been shown to deliver any biological importance, mercuric(II) ion (Hg 2+) is a deleterious cation which poses grievous effects to the human body and/or the ecosystem, hence, the need for its sensitive and selective monitoring in both environmental and biological systems. Over the years, there has been a great deal of work in the use of fluorescent, colourimetric, and/or ratiometric probes for Hg 2+ recognition. Essentially, the purpose of this review article is to give an overview of the advances made in the constructions of such probes based on the works reported in the period from 2011 to 2019. Discussion in this review work has been tailored to the kinds of fluorophore scaffolds used for the constructions of the probes reported. Selected examples of probes under each fluorophore subcategory were discussed with mentions of the typically determined parameters in an analytical sensing operation, including modulation in fluorescence intensity, optimal pH, detection limit, and association constant. The environmental and biological application ends of the probes were also touched where necessary. Important generalisations and conclusions were given at the end of the review. This review article highlights 196 references. Keywords Mercuric(II) ion (Hg 2+) • Fluorescent probes • Colourimetric probes • Ratiometric probes • Hg 2+-selective probes • Sensing

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Recent Advances in Mercury Research

Cited by 50 publications

References 40 publications

The Clinical Test of Nano gold Cosmetic for Recovering Skin Damage Due to Chemicals: Special Case

The Clinical Test of Nano gold Cosmetic for Recovering Skin Damage Due to Chemicals: Special Case

Oxidative Damage in Human Periodontal Ligament Fibroblast (hPLF) after Methylmercury Exposure

Fluorescent, colourimetric, and ratiometric probes based on diverse fluorophore motifs for mercuric(II) ion (Hg2+) sensing: highlights from 2011 to 2019

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