Recent advances in management of organophosphate &amp; carbamate poisoning

Kumar, Ashok; Margekar, Shubha Laxmi; Margekar, Purnima; Margekar, Venugopal

doi:10.1016/j.injms.2018.06.007

Cited by 17 publications

(10 citation statements)

References 9 publications

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“…Diagnosis mainly is based on clinical signs. 7 Measurement of plasma cholinesterase is the most distinct test of OP poisoning. 8 Early antagonism of OP poisoning as evidence suggested, should be accompanied by better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Serum amylase as a prognostic marker of organophosphate poisoning

Zobeiri

2021

J Inj Violence Res

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Background: Organophosphate (OP) insecticides are important compounds as the most probable common cause of acute poisonings in developing countries. OP intoxication often presents as medical emergencies, and its related morbidity and mortality have not decreased despite major advances in critical care. This study aims to determine the impact of serum amylase level for estimation of prognosis in patients with acute OP poisoning.Methods: This observational case-control study was done during two years on 332 consecutive patients with acute OP poisoning. Clinical and demographic data, serum amylase level on early admission time, morbidity, and outcome were determined. Data were analyzed in the form of a frequency distribution table by using SPSS 11.0 version software. Results:The mean age of patients with acute OP poisoning was 28.9 ± 23.95 with slightly female dominance. All patients were intoxicated via the gastrointestinal route. The mean amylase level of patients with deterioration of mental status, tachycardia, ICU admission, and death was significantly higher. Conclusion:Among patients with OP poisoning, higher serum amylase than normal was associated with severe clinical course and increased risk for mortality. Determination of serum amylase can be effective in the quick prediction of the outcome.

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Section: Introductionmentioning

confidence: 99%

Serum amylase as a prognostic marker of organophosphate poisoning

Zobeiri

2021

J Inj Violence Res

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“…Management involves resuscitation, antidote, gastric decontamination, and supportive care. Immediate assessment and stabilizing the airway, breathing, and circulation is one of the keystones in management (4) . Nurses are typically the first health care providers to contact patients who have consumed poisons.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Nurses' Role Regarding Care of Patients with Acute Organophosphate Poisoning

Mohamed

Taha

Zytoon

et al. 2023

Zagazig Nursing Journal

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Background: Acute organophosphate poisoning is a major health problem presents worldwide and is responsible for much mortality especially in developing countries. Early identification and effective management in the initial stages increase rate of survival among these patients. Nurses' role remains long standing determinates of quality care rendered for patients, many factors affecting nurses' role include physical, psychological, professional, patient related factors and work-related factors. So, nurses' play a core role in the management of acute organophosphate poisoning through closely monitoring of patients and providing quality nursing care. Aim of the study was to determine factors affecting nurses' role regarding care of patients with acute organophosphate poisoning. Subjects and Methods: Research design: A descriptive research design was carried out in this study Setting: The present study was conducted in emergency department and poisoning unit at Zagazig university hospitals Subjects: A convenience sample of all available nurses (70). Tool of data collection: Two tools were used for collecting data: Tool I: A structured interview questionnaire about demographic characteristics of the studied nurses, nurses` knowledge, and factor which affect nurses' role. Tool II: Observational checklist to assess nurses' practices. Results: More than three quarters (75.7%) of studied nurses had unsatisfactory total knowledge, more than two thirds (68.6. %) of studied nurses had unsatisfactory total practice regarding care of patients with acute organophosphate poisoning and 67.1%, 58.6% & 77.1% of factors related to nurse, factors related to patient, and factors related to work respectively affected nurses' role regarding care of patients with acute organophosphate poisoning. Conclusion: There was a positive significant correlation between total knowledge, total practice, and factors affecting nurses' role. Recommendation: Training programs are recommended to improve nurses' knowledge and practice regarding care of patients with acute organophosphate poisoning. Factors affecting nurses' role should be evaluated by the nursing management and hospital administration to avoid or correct such factors.

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“…Importantly, these two insecticide classes have been widely utilized and feature a strong neurotoxic activity, thus posing a potential health risk to consumers in case of dietary exposure. 12,13 Firstly, an ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QqQ-MS) method was optimized and validated for the detection of 97 OP and CM pesticide residues in the wheat our matrix providing exceptional detectability and accuracy. In terms of bioanalytical assays, aer investigating the inhibitory strength of 11 pesticide residues contained in the target list of the in-house chromatographic method, an acetylcholinesterase (AChE) inhibition assay for carbofuran (a CM insecticide) screening in wheat, rye and maize our matrices was developed and validated.…”

Section: Introductionmentioning

confidence: 99%