Recent advances in isotope dilution analysis for elemental speciation

Rodríguez-González, Pablo; Alonso, J. Ignacio García

doi:10.1039/b924261a

Cited by 51 publications

(34 citation statements)

References 115 publications

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“…The main differences between them are that ESI-MS is sensitive to concentration and both covalent and noncovalent bonds are preserved, while MALDI-MS is mass sensitive and only covalent bonds are preserved. Several very interesting reviews and papers consider the use of organic mass spectrometry [174], inorganic mass spectrometry [7,175] and isotopic dilution techniques [176][177][178][179] in bioinorganic analytical chemistry.…”

Section: Analytical Strategies and Techniques For Multielement Biologmentioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography-inductively coupled plasma-based "metallomics" methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.

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Section: Analytical Strategies and Techniques For Multielement Biologmentioning

confidence: 99%

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

et al. 2012

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“…This invaluable feature delivers the possibility for isotope dilution (ID) analysis, which is discussed elsewhere in detail [1,4,5,[7][8][9]. Another important field of application are tracer and migration studies based on natural or anthropogenic variations in the isotopic composition of certain elements (e.g.…”

Section: Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Environmental application of elemental speciation analysis based on liquid or gas chromatography hyphenated to inductively coupled plasma mass spectrometry—A review

Popp

Hann

Koellensperger

2010

Analytica Chimica Acta

113

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“…It is also mandatory to know the (hetero)element stoichiometry, to be able to calculate the concentration of the target protein via the measured (hetero) element content. 116 Species-Specific Isotope Dilution. The above-mentioned limitations can be overcome by the application of the species-specific isotope dilution approach, since it allows any losses during the analytical procedure to be compensated, assuming that the species-specific isotopically labeled spike compound and the targeted analyte reach chemical equilibrium prior to sample extraction.…”

Section: 94mentioning

confidence: 99%

“…108,[180][181][182] Based on this development, Prange and Schaumlöffel et al pioneered the field of sulfur isotopedilution analysis by combining postcolumn non-species-specific isotope dilution and capillary electrophoresis hyphenated to sector field ICP-MS for the highly resolved separation of different metallothionein (MT) isoforms, which allowed determination of the metal stoichiometry of the different isoforms as well as their absolute quantification. 183,184 A non-species-specific element spike containing 34 S, 65 Cu, 68 Zn, and 116 Cd introduced via the make-up flow of the CE interface was used for on-line isotope ratio measurement of 32 S/ 34 S, 63 Cu/ 65 Cu, 64 Zn/ 68 Zn, and 114 Cd/ 116 Cd. Reversed isotope dilution, using a standard solution containing S, Cu, Zn, and Cd with natural isotopic abundances, has been used for mass flow calibration of the different elements.…”

mentioning

confidence: 99%

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

2012

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This focal point review provides an overview of recent developments and capabilities of inductively coupled plasma mass spectrometry (ICP-MS) coupled with different separation techniques for applications in the fields of quantitative environmental and bio-analysis. Over the past years numerous technical improvements, which are highlighted in this review, have helped to promote the evolution of ICP-MS to one of the most versatile tools for elemental quantification. In particular, the benefits and possibilities of using state-of-the-art hyphenated ICP-MS approaches for quantitative analysis are demonstrated with a focus on environmental and bio-analytical applications.

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Recent advances in isotope dilution analysis for elemental speciation

Cited by 51 publications

References 115 publications

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

Environmental application of elemental speciation analysis based on liquid or gas chromatography hyphenated to inductively coupled plasma mass spectrometry—A review

Inductively Coupled Plasma–Mass Spectrometry (ICP-MS) for Quantitative Analysis in Environmental and Life Sciences: A Review of Challenges, Solutions, and Trends

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