Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms

Abstract

Natural products modulate interactions between gut microbiota and host.

Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation

“…Many natural products (NPs) have been shown to confer advantages for health by modulating the composition of the gut microbiota. − Ginseng is a highly esteemed herbal medicine, and ginsenosides, as the primary active constituents of ginseng, have been employed in treating various pathological conditions, including antioxidant, anti-inflammatory, and antitumor . Ginsenoside compound K (CK) is a unique and rare ginsenoside converted from the metabolic transformation of diol-type ginsenosides Rb1 and Rb2 by gut microbiota enzymatic reactions.…”

Natural products from the human microbiome: an emergent frontier in organic synthesis and drug discovery

“…7 This has led to intense activities and interest in the identification, biosynthesis and functions of secondary metabolites (natural products) from the human microbiome, especially in those derived from human commensal bacteria. 8,9…”

“…10 Hence, culture-independent genomic approaches, supported by computational algorithms for processing large volumes of genetic information from HMP reference genomes and interfacing with phenotypic data, were explored. 8–17 In this regard, the three commonly pursued approaches are (a) sequence-based metagenome mining, (b) functional genomics and (c) mass spectrometry-based metabolomics analysis.…”

Recent Advances in Chemical Synthesis of Structural Domains of Lipopolysaccharides from the Commensal Gut‐Associated Microbiota

“…Traditionally, LPS from the pathogenic bacteria are dangerous and harmful to human health via the host immune system overactivations, including the induction of metabolic endotoxemia, the promotion of dysglycemia and adipose inflammation, and the impairment of gut barrier function. [6] However, recent studies demonstrated that LPS from the commensal gut microbiota were beneficial for human health and played crucial roles in auto-immunity and immune homeostasis. [7] Structural differences of the commensal gut microbiota-derived LPS are believed to be reasons for the different immunological properties.…”