Recent Advances in Chemical Synthesis of Structural Domains of Lipopolysaccharides from the Commensal Gut‐Associated Microbiota

Abstract

Lipopolysaccharides from the commensal gut‐associated microbiota are interesting biomolecules for the treatment of various inflammatory diseases. Different from pathogenic lipopolysaccharides, commensal lipopolysaccharides have distinct chemical structures and mediate beneficial homeostasis with the immune system of host. However, the accessibility issues of homogenous and pure commensal lipopolysaccharides hampered the in‐depth studies of their functions. In this concept article, we highlight the recent synthesis of lipopolysaccharides from gut‐associated lymphoid‐tissue‐resident Alcaligenes faecalis and Bacteroides vulgatus, which hopes to inspire the more efforts devoting to this fantastic biomolecules.

Total Synthesis of Nona-decasaccharide Motif from Ganoderma sinense Polysaccharide Enabled by Modular and One-Pot Stereoselective Glycosylation Strategy

“…Nonetheless, because of stereoselectivity and regioselectivity issues , during glycans assembly, glycans synthesis remains tedious and time-consuming. While the milestone synthesis of 92-mer arabinogalactan and 101-mer mannose-capped lipoarabinomannan from Mycobacterium tuberculosis , 100-mer and 151-mer mannans, 128-mer O-antigen from Bacteroides vulgatus , 140-mer arabinogalactan from Panax notoginseng , and 1080-mer arabinan has been achieved in recent years, efficient synthesis of long, branched, and complex glycans containing many 1,2- cis -glycosidic linkages over 10-mer remains a challenging task …”