Recent advances in gel technologies for topical and transdermal drug delivery

Rehman, Khurram; Zulfakar, Mohd Hanif

doi:10.3109/03639045.2013.828219

Cited by 209 publications

(139 citation statements)

References 90 publications

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“…Vehicle composition has been shown to influence the release properties of the incorporated drug and the penetration ability across/into the skin and may also improve the skin condition 3,4,33 . To examine the effect of the vehicle on the release of liposomally entrapped diclofenac sodium, different types of liposomes were incorporated into the following vehicles: the hydrogel, the cream base (O/W emulsion) and DMS base.…”

Section: Liposomes-in-vehicle Formulationsmentioning

confidence: 99%

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Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Palac

Hurler

Škalko‐Basnet

et al. 2014

Drug Development and Industrial Pharmacy

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Objective: The present study is focused on optimization of elastic liposomes-in-vehicle formulations in respect to drug release and formulation properties. By combining penetration potential of elastic liposomes containing high ratio of entrapped drug and physicochemical properties of vehicles, both affecting the release and texture properties, optimal formulation could be achieved. Materials and methods:Deformable, propylene glycol-containing or conventional liposomes with hydrophilic model drug (diclofenac sodium) were incorporated into the following vehicles appropriate for skin application: a hydrogel, a cream base and derma membrane structure base cream (DMS base). Each formulation was assessed for in vitro drug release and mechanical properties. Results and discussion:The composition and type of both liposomes and the vehicle affected the rate and amount of the released drug. The cream base exhibited the slowest release, followed by the hydrogel and DMS base. Similar release profiles were achieved with both types of elastic vesicles (deformable and propylene glycol liposomes); the slowest release was observed for conventional liposomes, regardless of the vehicle used. The drug release profiles from different liposomes-in-vehicle formulations were in agreement with the physicochemical properties of the formulations. All of the liposomes were found to be compatible with the hydrogel preserving its original textures, whereas a significant decrease in all texture parameters was observed for liposomes-in-DMS base, regardless of liposome type. Conclusion:Propylene glycol liposomes-in-hydrogel is considered as the optimal formulation for improving skin delivery of hydrophilic drug. Further investigations involving in vivo animal studies are necessary to confirm its applicability in skin therapy. INTRODUCTIONEffective (trans)dermal drug delivery depends on both the selection of an appropriate drug and the properties of the delivery system (vehicle). Vehicles exert pronounced effects on the epidermis, affecting hydration, lubrication, drying, skin smoothness, occlusion and protection.In addition, the physicochemical properties of vehicles influence the pharmacokinetic properties of the incorporated drug by controlling its release from the vehicle and affecting penetration through the stratum corneum, permeation through the layers of skin and absorption into the blood. Preparation and characterization of liposomesDeformable, propylene glycol and conventional liposomes were prepared by the film 6The mean diameters, size distributions (polydispersity) and zeta potentials of the liposomes were determined by photon correlation spectroscopy (Zetasizer 3000HS, MalvernInstruments, Malvern, UK) 20,21 . Membrane elasticity of extruded liposomes was evaluated by home-made device at an external pressure of 5 bar using 100-nm membranes. Detailed procedure with equation for calculation of the deformability degree (E) has been previously described in details 14,19 . Separation of the unentrapped drug was performed usin...

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Section: Liposomes-in-vehicle Formulationsmentioning

confidence: 99%

“…Therefore, interactions between the vehicle, skin and drug can influence the final therapeutic effect of the applied formulation 1,2 . For this reason, the selection of an appropriate vehicle is an important factor in increasing the efficacy of a topically applied drug 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Palac

Hurler

Škalko‐Basnet

et al. 2014

Drug Development and Industrial Pharmacy

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“…As hydrogels are thermo-sensitive, therefore as the temperature increased, the percentage of weight loss was faster as compared to bigel formulations. Oleogels are known to be more resistant to temperature changes 7,31 , therefore the as the fish oil ratio increased in bigel formulations so does the thermal stability Fig. 4b .…”

Section: Thermal Gravimetric Analysismentioning

confidence: 99%

Development and Physical Characterization of Polymer-Fish Oil Bigel (Hydrogel/Oleogel) System as a Transdermal Drug Delivery Vehicle

2014

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“…Physiochemical properties of the drug delivery system (Rehman & Zulfakar, 2014;Schoellhammer et al, 2014) Release characteristics…”

Section: Diffusion Coefficientmentioning

confidence: 99%

Permeation enhancer strategies in transdermal drug delivery

et al. 2014

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Today, $74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive techniques of drug delivery. Several important advantages of transdermal drug delivery are prevention from hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Human skin surface, as a site of drug application for both local and systemic effects, is the most eligible candidate available. New controlled transdermal drug delivery systems (TDDS) technologies (electrically-based, structure-based and velocity-based) have been developed and commercialized for the transdermal delivery of troublesome drugs. This review article covers most of the new active transport technologies involved in enhancing the transdermal permeation via effective drug delivery system.

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Recent advances in gel technologies for topical and transdermal drug delivery

Cited by 209 publications

References 90 publications

Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle

Development and Physical Characterization of Polymer-Fish Oil Bigel (Hydrogel/Oleogel) System as a Transdermal Drug Delivery Vehicle

Permeation enhancer strategies in transdermal drug delivery

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