Recent advances in gastrointestinal cancers

Bordry, Natacha; Astaras, Christoforos; Ongaro, M; Goossens, Nicolas; Frossard, Jean Louis; Koessler, Thibaud

doi:10.3748/wjg.v27.i28.4493

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…Gastrointestinal (GI) cancers are some of the most common cancers in the world. GI cancers include malignancies of the GI tract (esophagus, stomach, small intestine, colon, rectum and anus) and other digestive organs (pancreas, gallbladder, liver and bile ducts) [ 1 ]. According to the International Agency for Research on Cancer’s estimation, there were about 5.1 million new GI cancer cases and over 3.5 million GI cancer deaths in the world in 2020 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Kalita

Sikora-Skrabaka

Nowakowska-Zajdel

2023

CIMB

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Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers.

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Section: Introductionmentioning

confidence: 99%

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Kalita

Sikora-Skrabaka

Nowakowska-Zajdel

2023

CIMB

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“…Gastrointestinal cancer (GI) is one of the major causes of death and disability worldwide [ 11 ]. The term “GI cancer” describes cancers that affect the digestive system, including, but not limited to, colorectal cancer and gastric cancer [ 12 ]. It is a multifactorial disease and can be influenced by environmental and genetic factors such as obesity, diet, smoking, infection, and low socioeconomic status [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids’ Dual Benefits in Gastrointestinal Cancer and Diabetes: A Potential Treatment on the Horizon?

Al-Ishaq

Mazuráková

Kubatka

et al. 2022

Cancers

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Diabetes and gastrointestinal cancers (GI) are global health conditions with a massive burden on patients’ lives worldwide. The development of both conditions is influenced by several factors, such as diet, genetics, environment, and infection, which shows a potential link between them. Flavonoids are naturally occurring phenolic compounds present in fruits and vegetables. Once ingested, unabsorbed flavonoids reaching the colon undergo enzymatic modification by the gut microbiome to facilitate absorption and produce ring fission products. The metabolized flavonoids exert antidiabetic and anti-GI cancer properties, targeting major impaired pathways such as apoptosis and cellular proliferation in both conditions, suggesting the potentially dual effects of flavonoids on diabetes and GI cancers. This review summarizes the current knowledge on the impact of flavonoids on diabetes and GI cancers in four significant pathways. It also addresses the synergistic effects of selected flavonoids on both conditions. While this is an intriguing approach, more studies are required to better understand the mechanism of how flavonoids can influence the same impaired pathways with different outcomes depending on the disease.

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“…In this case of locally advanced neoplasm, the CXRT (chemo-radiation therapy) is used, which allows usually for the reduction of local recurrence, but usually does not affect distant metastases. This treatment is followed by surgery for 8–12 weeks [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Selected Serpins in Gastrointestinal (GI) Malignancies

Pączek

Mroczko

2022

JCM

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Gastrointestinal (GI) cancers, which are a diverse group of malignant diseases, represent a major healthcare problem around the world. Due to the lack of specific symptoms in the early stages as well as insufficient diagnostic possibilities, these malignancies occupy the leading position in the causes of death worldwide. The currently available tests have too many limitations to be part of routine diagnostics. Therefore, new potential biomarkers that could be used as diagnostic and prognostic factors for these cancers are still being sought. Among the proteins that might fit this role are serpins, which are serine protease inhibitors. Although the serpins themselves have been known for many years, they have recently become the centre of attention for many authors, especially due to the fact that a number of proteins in this family are involved in many stages of neoplasia formation, from angiogenesis through tumour growth to progression. Therefore, the aim of this review is to present the current knowledge about the significance of serpins in GI malignancies, especially their involvement in the development and progression of oesophageal, gastric, pancreatic and colorectal cancers. This review summarises and confirms the important roles of selected serpins in the pathogenesis of various GI cancers and also points to their promising roles as therapeutic targets. However, due to the relatively nonspecific nature of serpins, future research should be carried out to elucidate the mechanisms involved in tumour pathogenesis in more detail.

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Recent advances in gastrointestinal cancers

Cited by 15 publications

References 34 publications

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Flavonoids’ Dual Benefits in Gastrointestinal Cancer and Diabetes: A Potential Treatment on the Horizon?

The Role of Selected Serpins in Gastrointestinal (GI) Malignancies

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