Recent Advances in Forensic DNA Analysis

Romeika, Jennifer M.; Yan, Fei

doi:10.4172/2157-7145.s12-001

Cited by 18 publications

(16 citation statements)

References 99 publications

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“…The involvement of the man in this particular case was proved as his profile was also generated from the vaginal swab and bite mark swab, which negated any chances of it being a coincidence. The forensic use of DNA Profiling (Identifiler coupled with Y-filer) is a major contribution to a technology which can help not only in including the culprit but also to exclude the innocent [24]. The minor DNA component is generally undetectable below a ratio of 1:25-1:50 for autosomal mixtures [19,25].…”

Section: Resultsmentioning

confidence: 99%

Y Chromosome STR Typing: A Distinguishing Tool for Exclusion in a Casework of Sexual Assault

Kaur¹,

Lamba²,

Gupta³

2017

J Forensic Res

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Section: Resultsmentioning

confidence: 99%

Y Chromosome STR Typing: A Distinguishing Tool for Exclusion in a Casework of Sexual Assault

Kaur¹,

Lamba²,

Gupta³

2017

J Forensic Res

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“…[16][17][18] Among the various techniques of biosensing such as surface plasmon resonance and UV-Vis spectroscopy and optical and electrochemical sensing, the last one has received immense attention due to its specific characteristics of high specificity, ease of fabrication, short response time, portability, and cost effectiveness. 19 This study is the first report of an electrochemical, on-chip DNA hybridization sensor for the early detection of PC. DNA sensors are widely explored, and significant progress has been made to design efficient gene sensors.…”

Section: -15mentioning

confidence: 89%

Graphene quantum dot-based on-chip electrochemical DNA hybridization sensor for pancreatic cancer

Joshi¹,

Waghmode²

2016

RIE

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Abstract:A new sensitive sensor based on graphene quantum dots was constructed and used to detect gene mutations in pancreatic cancer (PC). PC is a leading cause of death worldwide and is considered a hard-to-treat malignancy due to its late diagnosis and lowest 5-year survival rate of 2%-7%. Despite significant advances in detection techniques, PC is often diagnosed at advanced stage, with limited treatment options available, which leads to death in the majority of cases. In this regard, it is extremely important to develop methods for early detection of this lethal disease. In this study, we explored the advantages of electrochemical biosensing and designed a simple screen-printed DNA sensor for the detection of gene mutation in PC. p16 is a tumor-suppressor gene, and alterations in the gene sequence are related to PC onset. Therefore, we explored the p16 gene as a cancer marker and designed an electrochemical on-chip sensor system for the early diagnosis of PC. Different electrochemical techniques, such as differential pulse voltammetry and electrochemical impedance spectroscopy, were applied along with other characterization techniques (eg, ultraviolet-visible spectroscopy, scanning and transmission electron microscopy) for designing a simple DNA hybridization sensor for PC. The biosensor showed a detection capability of 0.10 pM. This study establishes the utilization of graphene quantum dots as a sensor matrix and a new approach for detecting gene mutation on a chip, which can be further developed as an integrated portable detection system.

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“…Forensic DNA has played a vital role in the criminal justice system. It allows effective human identification [27,28,29]. Some other applications include the field of bioelectronics, photodynamic therapy, a clinical diagnosis which is based on the interaction of DNA with a different chemical probe [30].…”

Section: Dna Applicationsmentioning

confidence: 99%

A Survey of Human Deoxyribonucleic Acid

Bello

Gbolagade

2017

BJAST

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Deoxyribonucleic Acid (DNA) is a molecule that carries most of the genetic instructions used in the development, functioning, and reproduction of all living organisms. The genes in living organisms contain instructions responsible for their characteristics which are transferred from parent to offspring to structure his life. These instructions are encoded in DNA molecule. This Paper presents a survey on DNA molecules in passing instructions from parents to their offspring from one generation to the other.

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Recent Advances in Forensic DNA Analysis

Cited by 18 publications

References 99 publications

Y Chromosome STR Typing: A Distinguishing Tool for Exclusion in a Casework of Sexual Assault

Y Chromosome STR Typing: A Distinguishing Tool for Exclusion in a Casework of Sexual Assault

Graphene quantum dot-based on-chip electrochemical DNA hybridization sensor for pancreatic cancer

A Survey of Human Deoxyribonucleic Acid

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