Recent advances in extraction of antioxidants from plant by-products processing industries

Selvamuthukumaran, M.; Shi, John

doi:10.1093/fqs/fyx004

Cited by 128 publications

(56 citation statements)

References 150 publications

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“…The heat applied on the extract facilitates the diffusion and solubility of the bioactive compounds, resulting in an increase of releasing of intracellular compounds. At any non-conventional method applied, the efficiency of the extraction rate is dependent on the choice of solvent [28]. Moreover, the result also was in an agreement with the results reported by Sultana et al, 2009, who found that reflux produced the highest yield regardless of the plant material and solvent used [29].…”

Section: Percentage Yield and Secondary Metabolites Screening Of C Psupporting

confidence: 89%

“…As previously discussed, at any non-conventional extraction method applied, the extraction competence depends on the choice of the solvent. [28]. Methanol extract from C. papaya was postulated to be the most efficient solvent as compared to water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane for antioxidant and antibacterial effects [13], and it is believed that these effects could contribute to the activities of wound healing.…”

Section: Collagen Synthesis By C Papaya Extractsmentioning

confidence: 99%

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Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities

et al. 2020

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Herbal plants are traditionally utilized to treat various illnesses. They contain phytochemicals that can be extracted using conventional methods such as maceration, soxhlet, and boiling, as well as non-conventional methods including ultrasonic, microwave, and others. Carica papaya leaves have been used for the treatment of dengue, fungal, and bacterial infections as well as an ingredient in anti-aging products. Phytochemicals analysis detected the presence of kaempferol, myricetin, carpaine, pseudocarpaine, dehydrocarpaine I and II, ferulic acid, caffeic acid, chlorogenic acid, β-carotene, lycopene, and anthraquinones glycoside. Conventional preparation by boiling and simple maceration is practical, simple, and safe; however, only polar phytochemicals are extracted. The present study aims to investigate the effects of three different non-conventional extraction techniques (ultrasonic-assisted extraction, reflux, and agitation) on C. papaya phytochemical constituents, the antioxidant capacity, and wound-healing activities. Among the three techniques, the reflux technique produced the highest extraction yield (17.86%) with the presence of saponins, flavonoids, coumarins, alkaloids, and phenolic metabolites. The reflux technique also produced the highest 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging with an IC 50 value of 0.236 mg/mL followed by ultrasonic-assisted extraction (UAE) (IC 50 : 0.377 mg/mL) and agitation (IC 50 : 0.404 mg/mL). At tested concentrations (3.125 µg/mL to 500 µg/mL), all extracts do not exhibit a cytotoxicity effect on the human skin fibroblast, HSF1184. Interestingly, reflux and UAE were active fibroblast proliferators that support 85% (12.5 µg/mL) and 41% (6.25 µg/mL) better cell growth, respectively. Additionally, during the early 24 h of the scratch assay, the migration rate at 12.5 µg/mL was faster for all extracts with 51.8% (reflux), 49.3% (agitation), and 42.5% (UAE) as compared to control (21.87%). At 48 h, proliferated cells covered 78.7% of the scratch area for reflux extract, 63.1% for UAE, 61% for agitation, and 42.6% for control. Additionally, the collagen synthesis was enhanced for 31.6% and 65% after 24 and 48 h of treatment for reflux. An HPLC-MS/MS-QTOF (quadruple time-of-flight) analysis of reflux identified nine phytochemicals, including carpaine, kaempferol 3-(2G-glucosylrutinoside), kaempferol 3-(2"-rhamnosylgalactoside), 7-rhamnoside, kaempferol 3-rhamnosyl-(1->2)-galactoside-7-rhamnoside, luteolin 7-galactosyl-(1->6)-galactoside, orientin 7-O-rhamnoside, 11-hydroperoxy-12,13-epoxy-9-octadecenoic acid, palmitic amide, and 2-hexaprenyl-6-methoxyphenol. The results suggested that reflux was the best technique as compared to ultrasonic and agitation.

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Section: Percentage Yield and Secondary Metabolites Screening Of C Psupporting

confidence: 89%

Section: Collagen Synthesis By C Papaya Extractsmentioning

confidence: 99%

Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities

et al. 2020

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“…A lot of research teams compared classical modern methods for the extraction of flavonoids from plant materials and discussed their advantages and disadvantages [4,[11][12][13][14][15][16]. But the focus was not on the selectivity of the reviewed methods.…”

Section: Introductionmentioning

confidence: 99%

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

et al. 2020

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Flavonoids have a broad spectrum of established positive effects on human and animal health. They find an application in medicine for disease therapy and chemoprevention, whence the interest in flavonoids increases. In addition, they are used in food and cosmetic industries as pigments and biopreservatives. Plants are an inexhaustible source of flavonoids. The most important step of plant raw material processing is extraction and isolation of target compounds. The quality of an extract and efficiency of a procedure are influenced by several factors: Plant material and pre-extracting sample preparation, type of solvent, extraction technique, physicochemical conditions, etc. The present overview discusses the common problems and key challenges of the extraction procedures and the different mechanisms for selective extraction of flavonoids from different plant sources. In summary, there is no universal extraction method and each optimized procedure is individual for the respective plants. For an extraction technique to be selective, it must combine an optimal solvent or mixture of solvents with an appropriate technique. Last but not least, its optimization is important for a variety of applications. Moreover, when the selected method needs to be standardized, it must achieve acceptable degree of repeatability and reproducibility.

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“…Ultrasound is a special type of sound wave beyond human hearing, with frequencies ranging from 20 to 100 MHz [51]. Advantages of UAE include shorter extraction times, low energy demands, and high extraction efficiency [16,52].…”

Section: Ultrasound Assisted Extraction (Uae)mentioning

confidence: 99%

Optimization Methods for the Extraction of Vegetable Oils: A Review

2020

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Most seed oils are edible while some are used generally as raw material for soap production, chocolate, margarine, and recently in biodiesel formulations as potential candidates capable of replacing fossil fuels which are costly and destructive to the environment. Oilseeds are a green and major reservoir which when properly exploited can be used sustainably for the production of chemicals at both the laboratory and industrial scales. Oil extraction is one of the most critical steps in seed oil processing because it determines the quality and quantity of oil extracted. Optimization of the extraction conditions for each extraction method enhances yield and quality meanwhile a carefully chosen optimization process equally has the potential of saving time and heat requirements with an associated consequence on cost reduction of the entire process. In this review, the techniques used to optimize oil extraction from plant materials which can be consulted by stakeholders in the field are brought to focus and the merits and demerits of these methods highlighted. Additionally, different types of optimization techniques used for various processes including modeling and the software employed in the optimization processes are discussed. Finally, the quality of the oil as affected by the methods of extraction and the optimization process used are also presented.

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Recent advances in extraction of antioxidants from plant by-products processing industries

Cited by 128 publications

References 150 publications

Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities

Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

Optimization Methods for the Extraction of Vegetable Oils: A Review

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