Recent Advances in Electrospun Nanofibers for Wound Healing

Chen, Shixuan; Liu, Bing; Carlson, Mark A.; Gombart, Adrian F.; Reilly, Debra A.; Xie, Jingwei

doi:10.2217/nnm-2017-0017

Cited by 301 publications

(230 citation statements)

References 174 publications

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“…Electrospinning and the fabrication of nanofibers based on bioactive polymers or by mixing polymers with metals having biological effects has been the subject of numerous researches . Recently a new class of dressings based on polymeric composite films, containing bioactive glass nanoparticles, appeared.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Alminderej

El‐Ghoul

2019

J of Applied Polymer Sci

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The present paper describes the development of wound dressing with high-enhanced biological characteristics. Firstly, we have synthesized a new polymer-based chitosan/hematoxylin (poly-PAA-CZ-HX), a bioactive blend for combined antibacterial and tissue regeneration properties. The main aim was to functionalize the wound dressing biomaterial with this bioactive medical polymer via a chemical grafting process. This functionalization must offer a permanent graft and preserve the medical properties of the added polymer of chitosan/hematoxylin. We have then studied the influence of different parameters involved in this particular grafting processing. Main parameters included thermofixation conditions (time and temperature) in addition to the concentration of different reactants. The last mentioned consist of a crosslinking agent the polyacrylic acid (PAA), a selected catalyst the sodium dihydrogen hypophosphite (NaH 2 PO 2 ), and thepoly-PAA-CZ-HX. Sorption capacity of modified dressings was then evaluated via the technique of the contact angle at various grafting rates. These wettability measurements have revealed a significant decrease of the contact angle of samples after functionalization, a desired characteristic of wound dressings, which means the clear improvement of the hydrophilicity. After the untreated and grafted cotton dressings were characterized by ATR-IR spectroscopy and TGA/DTA analysis, the results showed a chemical permanent grafting that resisted to standardized washings. Then an evaluation of mechanical properties of cotton dressings grafted with various proportions of poly-PAA-CZ-HX polymer was accomplished. Results revealed that the grafting reaction with selected conditions did not damage the mechanical characteristics of our native wound dressings. Finally, a SEM morphological study confirmed the permanent graft of the crosslinked CZ/HX biopolymer grafted to the cotton fibers and allowed us to evaluate its chemical grafting mode onto functionalized surfaces.

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Section: Introductionmentioning

confidence: 99%

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Alminderej

El‐Ghoul

2019

J of Applied Polymer Sci

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“…[275] Loading antimicrobials agents, growth factors, vitamins, and drugs into nanofibers provides a great potential in the development of an effective antimicrobial system able to treat infections in the wound regions, prohibition of bacterial biofilm formation, prolonging drug release, and decreasing the time of wound healing process. [37][38][39][276][277][278] Collagen, [131,279] polyvinyl alcohol, [280] polyvinylpyrrolidone, [281,282] polyacrylic acid, [283,284] gelatin, [285] chitosan, [286] silk fibroin, [19] polyesters and polyurethane [39] have been used to fabricate nanofibrous materials as a wound dressing. There is need to attain smart nanofiber with the ability to provide optimal drug release profiles and rates of release according to the type of wound, the conditions of the wound and subsequently, start the release of drug agents with the optimum delivery profile only when needed to treat in the wound region.…”

Section: Nanofibers For Wound Healing and Skin Carementioning

confidence: 99%

Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

196

112

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Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.

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“…[138] To overcome these deficiencies, a number of 3D tumor models have been proposed, in the form of microfluidic devices [139] , natural and synthetic polymer scaffold or hydrogel [140] , and spheroids [141] . Among them, electrospun nanofiber scaffolds provide an alternative artificial 3D culture matrix due to their biomimicry of the architecture and composition of ECM [142] , and high versatility in biochemical stimuli, including growth factors, adhesion molecules, and drugs [12,143] . Cells cultured on the scaffolds respond to the biochemical stimuli through specific interactions between cell surface receptors and the immobilized ligands.…”

Section: Emerging Roles Of Electrospun Nanofibers In Cancer Researchmentioning

confidence: 99%

Emerging Roles of Electrospun Nanofibers in Cancer Research

Chen

Boda

Batra

et al. 2017

Adv Healthcare Materials

Self Cite

119

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This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.

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Recent Advances in Electrospun Nanofibers for Wound Healing

Cited by 301 publications

References 174 publications

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Synthesis and study of a new biopolymer‐based chitosan/hematoxylin grafted to cotton wound dressings

Nanofibers for Biomedical and Healthcare Applications

Emerging Roles of Electrospun Nanofibers in Cancer Research

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