Emerging Roles of Electrospun Nanofibers in Cancer Research

Chen, Shixuan; Boda, Sunil Kumar; Batra, Surinder K.; Li, Xiaoran; Xie, Jingwei

doi:10.1002/adhm.201701024

Cited by 127 publications

(95 citation statements)

References 184 publications

(351 reference statements)

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“…Not only do they provide physical protection to the wound, but they also have the capacity to be incorporated with a high amount of drugs (up to 40% loading), where the release of which can be adjusted by changing the types and compositions of the materials in the fibers [ 29 ]. A large variety of materials can be used to produce electrospun fibers in the pursuit of medical fabrics in wound dressing [ 26 ], and these materials can be categorized into natural and synthetic polymers [ 27 , 30 ]. In addition, hydrophilic polymers are ideal for encapsulation of small molecules, proteins, peptides, and gene vectors.…”

Section: Electrospun Fibersmentioning

confidence: 99%

“…It accommodates much more polymer combinations as compared to the blend fibers since the core and the shell can be from different polymer-solvent system. Core-shell fibers provide the ability to intentionally incorporate hydrophilic and/or hydrophobic drugs at the core of the fibers while the shell serves as a protective layer to prevent burst of the surface drugs [ 30 ]. This method not only allows more possible formations of drugs and polymers, but also can prolong the release of the drug to the wound site.…”

Section: Electrospun Fibersmentioning

confidence: 99%

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Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

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Section: Electrospun Fibersmentioning

confidence: 99%

Section: Electrospun Fibersmentioning

confidence: 99%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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“…However, there are still no superior products available which can perfectly achieve complete wound closure [15]. Tissue-engineered dressings provide a promising solution for skin regeneration [16].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Materials for Wound Healing

et al. 2020

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Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired. Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this review article, we begin with a discussion of wound healing process and current commercial wound dressing materials. Then, we emphasize on electrospun nanofibrous materials for wound dressing, covering the efforts for controlling fiber alignment and morphology, constructing 3D scaffolds, developing waterproof-breathable membrane, governing drug delivery performance, and regulating stem cell behavior. Finally, we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.

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“…Generally, electrospun nanofibers could effectively carry both hydrophobic and hydrophilic drugs and achieve a sustained drug release profile, which enables them to serve as desired platform for biomedical applications, including wound dressing [9,10], anti-bacterial [11,12] and antitumor drug delivery [7,13,14]. However, conventional drugloaded nanofibers were simply prepared by directly doping drugs within polymer solutions before electrospinning to form the nanofibers, and always exhibit a burst drug release profile [15].…”

Section: Introductionmentioning

confidence: 99%

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

2019

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Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area, good biocompatibility, easy fabrication and surface modification. In particular, organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs, which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering applications. This review summarizes the recent progresses in the preparation, performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy, and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering applications. Nanofibers doped with various types of inorganic nanoparticles (e.g., halloysite, laponite ® , nano-hydroxyapatite, attapulgite, carbon nanotubes, and graphene, etc.) are introduced and summarized in detail. Future perspectives are also briefly discussed. Graphic AbstractKeywords Electrospun nanofibers · Hybrid nanofibers · Drug delivery · Tissue engineering

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Emerging Roles of Electrospun Nanofibers in Cancer Research

Cited by 127 publications

References 184 publications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Electrospun Nanofibrous Materials for Wound Healing

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

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