Electrospun Nanofibrous Materials for Wound Healing

Dong, Youming; Zheng, Yuqi; Zhang, Keyan; Yao, Yueming; Wang, Lihuan; Li, Xiaoran; Yu, Jianyong; Ding, Bin

doi:10.1007/s42765-020-00034-y

Cited by 151 publications

(90 citation statements)

References 166 publications

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“…This work introduced a key idea to design A–P controllable metasurfaces within the terahertz and microwave bands, by considering the cross‐polarized response in view of its broader operational bandwidth, relatively simple design procedure, and weaker interactions between the amplitude and phase responses, thereby paving the way to a series of interesting applications. [ 33–36 ] However, this working mechanism does not enable an anisotropic response, i.e., independent control of the responses to two linear, orthogonal polarizations. Subsequent studies have demonstrated the possibility to control copolarized amplitude and phase responses by relying on indium tin oxide‐based [ 37 ] and Huygens [ 38 ] metasurfaces, but with inherent restrictions in the attainable amplitude range, or the operability limited to a single polarization.…”

Section: Figurementioning

confidence: 99%

“…Within this framework, available designs include both reflection‐ and transmission‐types as well as dual‐frequency operation. [ 33,34,45,46 ] However, the polarization state has not hitherto been exploited to reconfigure the focusing functionality in view of the inherent difficulty in achieving A–P control with anisotropic characteristics. Aimed to solve these problems, we will take advantages of our proposed A–P controllable to construct the synthesis of multiple equal‐power vortex‐beam radiation patterns and polarization‐reconfigurable multifocal metalenses.…”

Section: Figurementioning

confidence: 99%

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Independent Control of Copolarized Amplitude and Phase Responses via Anisotropic Metasurfaces

Bao

et al. 2020

Advanced Optical Materials

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A class of anisotropic, transmissive electromagnetic metasurfaces is presented, which enable independent and simultaneous control of copolarized phase and amplitude responses to two linear, orthogonal polarizations. By varying the geometrical parameters, the transmission response of the proposed structure can yield a full phase coverage, accompanied by broadly adjustable amplitude and negligible cross‐polarized components. The full amplitude‐phase control together with the novel anisotropic character allows efficient implementation of complicated field manipulations. As representative application examples, which cannot be realized via conventional (phase‐only) metasurfaces, it is presented here: (1) the radiation of multiple equal‐power vortex beams (along arbitrarily predesigned directions, with designable orbital angular momentum modes under different polarizations), and (2) the realization of polarization‐reconfigurable multifocal metalenses. Full‐wave numerical simulations and experimental results demonstrate good agreement and confirm the versatility and effectiveness of the proposed approach to design advanced field‐manipulation systems.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Independent Control of Copolarized Amplitude and Phase Responses via Anisotropic Metasurfaces

Bao

et al. 2020

Advanced Optical Materials

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“…Inexpensive and readily available conventional wound dressings such as gauze and bandages can basically protect the wound from external agents, but they create a dry environment locally, which can lead to complications, such as subsequent infections [2,10]. In recent years, considerable advances have been achieved in designing modern dressings to protect the wound from dehydration and infection, and facilitate the healing process instead of just covering the wound [3,11,12]. Wound dressings in the form of hydrogels [13][14][15], hydrocolloids [16][17][18], sponges [19][20][21][22], alginates [23][24][25], and transparent films [11] have been developed and some of them are commercially available.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to flexibility in choosing the raw materials and the possibility to tune the ultimate properties, the electrospinning technique has been extensively employed for biomedical materials like tissue engineering scaffolds, wound dressings, and drug delivery systems [7,8]. Electrospun structures composed of fibers with nano-scale diameter are proposed as ideal wound dressings and tissue substitutes due to their similarity to the extracellular matrix (ECM) fibrillar part [11,26,29,30]. Owing to the large specific surface area and high porosity with small pore size, these materials present efficient performance for improving the healing process.…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

135

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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“…For example, anisotropic metasurfaces, composed of arrays of subwavelength meta‐atoms with asymmetric structural anisotropy along two principle axes, have been proposed and demonstrated for polarization multiplexing on two arbitrary orthogonal states and spins of linearly polarized (LP) and circularly polarized (CP) waves . In addition, versatile functionalities could also be achieved by exploiting wavelength and frequency multiplexing, which involves various multimode resonators that each operate individually at well‐separated frequencies . The other notable avenue of increasing information delivery channels in metasurfaces is spatial multiplexing, which has only recently been demonstrated in spatially interleaved closely packed structures in several sectors of a common layer or multilayer .…”

Section: Introductionmentioning

confidence: 99%

Wavevector and Frequency Multiplexing Performed by a Spin‐Decoupled Multichannel Metasurface

Jiang

et al. 2019

Adv Materials Technologies

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Achieving kaleidoscopic wavefront controls with a thin flat plate is pivotal for increasing data capacity yet still challenging in integrated optics. An anisotropic metasurface provides an efficient recipe primarily for linear polarization, but is less efficient for multiple functionalities at arbitrary spin states. Here, a strategy of realizing a spin‐decoupled high‐capacity multifunctional metasurface by multiplexing the frequency and wavevector degree of freedom (DoF) is reported. By integrating both geometric and dynamic phases in split ring resonators and crossbars in a chessboard configuration, the inherent limitation of spin‐flipped Pancharatnam–Berry phases can be completely decoupled between two spin states. Such released extraordinary DoF unprecedentedly increases the capability to yield kaleidoscopic wavefront control. To verify the significance, two proof‐of‐concept metadevices that are nearly impossible in conventional metasurfaces are experimentally demonstrated with four‐port wavefront manipulations, exhibiting spin‐, frequency‐, and wavevector‐dependent anomalous reflections, lensing, orbital angular momentum generation, and wavevector‐multiplexed vortex scattering, along with two‐dimensional holograms. Both numerical and experimental results illustrate quad‐distinct functionalities with up to ten channel beams and ≈93% efficiency, because of the completely suppressed crosstalk among different operation modes, angular wavevectors, and spins. The finding in triple‐DoF multiplexing is expected to generate great interest in electromagnetic integration with emerging DoFs.

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Electrospun Nanofibrous Materials for Wound Healing

Cited by 151 publications

References 166 publications

Independent Control of Copolarized Amplitude and Phase Responses via Anisotropic Metasurfaces

Independent Control of Copolarized Amplitude and Phase Responses via Anisotropic Metasurfaces

Bio-Based Electrospun Fibers for Wound Healing

Wavevector and Frequency Multiplexing Performed by a Spin‐Decoupled Multichannel Metasurface

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