Recent Advances in Cross-Dehydrogenative-Coupling Reactions Using Molecular Oxygen as the Sole Oxidant

Copper-catalyzed room-temperature cross-dehydrogenative coupling of secondary amides with terminal alkynes: a chemoselective synthesis of ynamides

“…Cross-dehydrogenative coupling (CDC) represents a class of atom- and step-economical methods. 10 The copper-catalyzed or -mediated CDC reaction of terminal alkynes and amides under an oxygen atmosphere is a highly effective strategy for the synthesis of ynamides, 11 owing to the direct use of readily available terminal alkynes and amides as substrates. However, the low reactivity of these substrates necessitates heating for these reactions to occur, leading to undesired alkyne homo-coupling dimers.…”

Recent advances in rhodium-catalysed cross-dehydrogenative-coupling between two C(sp2)–H bonds

“…9 In recent years, the CDC reaction has become one of the most active research areas in modern organic synthesis and has shown many successful synthetic applications. 10 While some reviews and books have covered transition-metal-catalysed CDC reactions, 11,12 this review herein mainly focuses on the advancement of Rh-catalysed CDC reactions for the construction of the C(sp 2 )–C(sp 2 ) bond with representative examples from 2016 to mid-2021 (Fig. 1).…”

Rhodium-Catalyzed Oxidative Annulation of 2- or 7-Arylindoles with Alkenes/Alkynes Using Molecular Oxygen as the Sole Oxidant Enabled by Quaternary Ammonium Salt

“…C-H functionalization, including the reaction of a C-H bond with a (pseudo)halide, the reaction of a C-H bond with an organometallic reagent, and cross-coupling between two C-H bonds (CDC reaction), has gained tremendous popularity in recent years as a methodology for the construction of C-C bonds or C-heteroatom bonds [1][2][3][4][5][6][7][8][9][10][11][12]. Among these reactions, the CDC reaction is especially noteworthy because this reaction precludes both coupling partners from pre-functionalization, and as a result has high step economy and atom economy [13][14][15][16][17][18][19][20][21]. In 2007, Miura and Satoh reported on [RhCp*Cl 2 ] 2 -catalyzed oxidative coupling of benzoic acids with alkynes [22].…”