Recent Advances in CMOS Electrochemical Biosensor Design for Microbial Monitoring: Review and Design Methodology

Hosseini, S. Nazila; Das, Partha Sarati; Lazarjan, Vahid Khojasteh; Gagnon-Turcotte, Gabriel; Bouzid, Karim; Gosselin, Benoît

doi:10.1109/tbcas.2023.3252402

Cited by 17 publications

(9 citation statements)

References 210 publications

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“…In addition to these chemical sensors, various types of chemical sensors employing combinations of different sensing elements such as metal–oxide–semiconductors (CMOSs), carbon nanotubes (CNTs), NPs and chemicals, and signal-transducing elements such as nanomaterial fabricated electrodes, LAPS, surface plasmon resonance (SPR), Raman spectroscopy, optic fiber, fluorescent spectrometry, and microfluidics to detect cells and diseases have been reported [ 38 , 39 , 40 , 41 ]. Moreover, new materials for target sensing are continuously being developed and applied to these sensor platforms due to the rapid advances in nanomaterials (NMs) and fabrication technologies.…”

Section: Chemical Sensor Systems For Cell Monitoringmentioning

confidence: 99%

The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring

Song,

Hwang,

Jeon

et al. 2024

IJMS

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Cell monitoring is essential for understanding the physiological conditions and cell abnormalities induced by various stimuli, such as stress factors, microbial invasion, and diseases. Currently, various techniques for detecting cell abnormalities and metabolites originating from specific cells are employed to obtain information on cells in terms of human health. Although the states of cells have traditionally been accessed using instrument-based analysis, this has been replaced by various sensor systems equipped with new materials and technologies. Various sensor systems have been developed for monitoring cells by recognizing biological markers such as proteins on cell surfaces, components on plasma membranes, secreted metabolites, and DNA sequences. Sensor systems are classified into subclasses, such as chemical sensors and biosensors, based on the components used to recognize the targets. In this review, we aim to outline the fundamental principles of sensor systems used for monitoring cells, encompassing both biosensors and chemical sensors. Specifically, we focus on biosensing systems in terms of the types of sensing and signal-transducing elements and introduce recent advancements and applications of biosensors. Finally, we address the present challenges in biosensor systems and the prospects that should be considered to enhance biosensor performance. Although this review covers the application of biosensors for monitoring cells, we believe that it can provide valuable insights for researchers and general readers interested in the advancements of biosensing and its further applications in biomedical fields.

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Section: Chemical Sensor Systems For Cell Monitoringmentioning

confidence: 99%

The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring

Song,

Hwang,

Jeon

et al. 2024

IJMS

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“…It has ushered in a new era of innovation, impacting the design and operation of electronic devices, from microprocessors in computers to sensors in smartphones and beyond [3]. At its core, CMOS leverages the unique properties of complementary transistor pairs, combining p-type and n-type transistors to create highly efficient and low-power digital logic circuits [4][5]. This complementary behavior results in minimal power consumption during idle states, rendering CMOS ideal for battery-powered and energy-efficient devices [6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Temperature and Channel Dimension Effects on CMOS Circuit Performance

Messai,

Brahimi,

Saidani

et al. 2024

East Eur. J. Phys.

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This paper presents the impact of temperature variations and alterations in transistor channel dimensions on CMOS (Complementary Metal-Oxide-Semiconductor) circuit technology. To facilitate this investigation, we first identified critical parameters characterizing the device's performance, which could exhibit susceptibility to these influences. The analysis encompassed critical metrics such as the transfer characteristic, drain current, logic levels, inflection points, and truncation points. These parameters enabled us to validate the results obtained from the PSPICE simulator, which demonstrated unequivocal effectiveness. Notably, our simulation results unveiled significant effects resulting from a wide temperature range spanning from -100°C to 270°C, offering valuable in-sights into thermal-induced failures. Additionally, the influence of channel dimension changes on factors like drain current and transfer characteristics, as well as temporal parameters including signal propagation delay and rise and fall times, were meticulously examined and appreciated.

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“…with biosensor arrays [1,2]. One widely used trend to address this challenge is incorporating complementary metal-oxide-semiconductor (CMOS) technology in the biosensor design (referred to as the CMOS biosensor), which provides the integration of a large number of transistors (i.e., enables array implementation) and cost-efficient and low-power consumption systems with a high production yield and robust functionality [3][4][5][6]. A CMOS-based biosensor comprises a microfluidic structure designed to direct samples toward sensing sites on the CMOS sensing chip.…”

Section: Introductionmentioning

confidence: 99%

A Multidisciplinary Approach toward CMOS Capacitive Sensor Array for Droplet Analysis

Osouli Tabrizi,

Forouhi,

Azadmousavi

et al. 2024

Micromachines

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This paper introduces an innovative method for the analysis of alcohol–water droplets on a CMOS capacitive sensor, leveraging the controlled thermal behavior of the droplets. Using this sensing method, the capacitive sensor measures the total time of evaporation (ToE), which can be influenced by the droplet volume, temperature, and chemical composition. We explored this sensing method by introducing binary mixtures of water and ethanol or methanol across a range of concentrations (0–100%, with 10% increments). The experimental results indicate that while the capacitive sensor is effective in measuring both the total ToE and dielectric properties, a higher dynamic range and resolution are observed in the former. Additionally, an array of sensing electrodes successfully monitors the droplet–sensor surface interaction. However practical considerations such as the creation of parasitic capacitance due to mismatch, arise from the large sensing area in the proposed capacitive sensors and other similar devices. In this paper, we discuss this non-ideality and propose a solution. Also, this paper showcases the benefits of utilizing a CMOS capacitive sensing method for accurately measuring ToE.

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Recent Advances in CMOS Electrochemical Biosensor Design for Microbial Monitoring: Review and Design Methodology

Cited by 17 publications

References 210 publications

The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring

The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring

Investigation of Temperature and Channel Dimension Effects on CMOS Circuit Performance

A Multidisciplinary Approach toward CMOS Capacitive Sensor Array for Droplet Analysis

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