Recent advances in capillary electrochromatography using molecularly imprinted polymers

Iacob, Bogdan-Cezar; Bodoki, Ede; Oprean, Radu

doi:10.1002/elps.201400253

Cited by 34 publications

(27 citation statements)

References 72 publications

(127 reference statements)

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“…The main drawback of this method is its poor repeatability in terms of controlling particle shape and particle size distribution, which are important when a large amount of MIP is needed. The classical bulk polymerization method is still in use, particularly in miniaturized reactors such as in capillary columns and nanochannels to give in situ prepared MIPs [28]. In the past decade more research has shifted to the use of new polymerization techniques that are scalable and can offer MIPs with well-defined size and formats.…”

Section: Reaction Systems Offering Mips With Controlled Formatsmentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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This chapter introduces the basic principle and the synthetic aspects of molecular imprinting. First, the use of a molecular template to guide the location of functional groups inside molecularly imprinted cavities is explained. Three different mechanisms that ensure a molecular template associates with functional monomers or the imprinted polymers, that is, through reversible covalent, noncovalent, and sacrificial covalent bonds, are then described. The main focus is put on noncovalent molecular imprinting using free radical polymerization. The merits of using classical radical polymerization and more sophisticated, controlled radical polymerization are analyzed. After these synthetic chemistry aspects, the chapter continues to discuss the different polymerization processes that can be used to prepare well-defined polymer monoliths, microspheres, and nanoparticles. New top-down processing techniques that produce micro- and nanopatterns of imprinted polymers are also reviewed. The chapter finishes with a brief introduction to using imprinted polymers as building blocks to construct new functional materials and devices, which we consider as one important direction for further development.

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Section: Reaction Systems Offering Mips With Controlled Formatsmentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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“…Upon removal of the template molecule from the polymer network, specific recognition sites, which are complementary to the template in terms of their size, shapes, and function, are exposed . Many applications have dealt with the use of MIPs as, stationary phases for chromatography , capillary electrochromatography , quartz crystal microbalance , membrane separation , solid phase extraction and biomimetic sensors .…”

Section: Introductionmentioning

confidence: 99%

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

et al. 2016

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A computational approach was developed to find a suitable functional monomer to design a new molecularly imprinted polymer (MIP), based on which methacyrlic acid (MAA) was selected as a functional monomer to synthesize the molecular imprinted and non‐imprinted polymers. All calculations were carried out using Gaussian 03 software based on the application of Hartree−Fock (HF) method with 6‐31G (d) basis set. The performance of the MIPs prepared with different ratios of MAA was then evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was chosen as recognition material for the fabrication of new PVC sensors and their responses were compared with each other and with previously reported modifiers in literature. The addition of the ionic surfactant (TFPB) was found to have a synergistic effect on the response mechanism of the electrodes. The results of the MIP modified sensors show that they provide an improved electrode slope, wider pH range and a highly extended life time reaching 7 months compared to 2–4 weeks in case of traditional ion‐exchangers reported in literature, besides, being successfully applied for measurements in biological samples.

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“…Polymer structures can be readily determined nowadays using a variety of different physicochemical methods, such as infrared spectroscopy [23], mass spectrometry [24,25], capillary electrophoresis [26] and liquid chromatography [27]. Furthermore, considerable progress has been made during the last decade toward the development of nuclear magnetic resonance (NMR) techniques for the analysis of natural [28] and synthetic polymers [29].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, evaluation and release studies of NIPA nanopolymers presumed for temperature-controlled drug delivery

Gasztych

Valh

Kokol

et al. 2016

J Sol-Gel Sci Technol

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The copolymers of N-isopropyl acrylamide (NIPA) have been studied extensively as drug carriers for antibacterial, cardiovascular, cytostatic, local anesthetic, and nonsteroidal anti-inflammatory agents, to deliver the required therapeutic effect. The aim of this work was to evaluate the effect of a series of newly synthesized thermosensitive polymeric NIPA derivatives on the release rate of naproxen sodium (NS) from hydrogels composed of hydroxypropyl methylcellulose (HPMC). NIPA derivatives P1-P4 were synthesized by precipitation polymerization without an emulsifier, and their structures were evaluated by NMR spectroscopy. Four formulations were prepared with NS (FP1-FP4), and rate of NS release from these systems was evaluated using a modified pharmacopeial method at 22 and 42°C. The release rate of NS followed a similar trend in all four of the formulations assessed at 22°C, which was the same as the reference formulation. However, the release rate of NS at 42°C was clearly faster in the samples containing the thermosensitive polymers P1-P4 compared with the reference formulation. These results clearly demonstrate that the use of thermosensitive polymeric derivatives of NIPA can increase the release rate of NS from hydrophilic gels based on HPMC.Graphical Abstract Diversity of release courses of naproxen sodium evaluated in formulation containing poly(ethylene glycol) dimethacrylate (PDA, left), and comparison of half-release times (T HR , right) of naproxen sodium formulations containing various thermosensitive polymers P1-P4.

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Recent advances in capillary electrochromatography using molecularly imprinted polymers

Cited by 34 publications

References 72 publications

Synthetic Strategies in Molecular Imprinting

Synthetic Strategies in Molecular Imprinting

Computational Design, Synthesis and Application of a New Selective Molecularly Imprinted Polymer for Electrochemical Detection

Synthesis, evaluation and release studies of NIPA nanopolymers presumed for temperature-controlled drug delivery

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