Recent Advances in Biologically Active Coumarins from Marine Sources: Synthesis and Evaluation

Abstract

Coumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological, and in particular, pharmacological properties. Interesting families of coumarins have been found from marine sources, which has accelerated the drug discovery process by inspiring innovation or even by the identification of analogues with remarkable biological properties. The purpose of this review is to showcase the most interesting marine-derived coumarins from a medicinal chemistry point of view, as well as the novel and useful synthetic routes described to date to achieve these chemical structures. The references that compose this overview were collected from PubMed, Mendeley and SciFinder.

Design, Synthesis, and Biological Activities of Novel Coumarin Derivatives as Pesticide Candidates

“…Coumarins are a promising class of naturally occurring bioactive heterocycles with unique physical and chemical properties. Compounds containing the coumarin framework possess a wide range of pharmacological, biological, and physiological activities, which makes them important for application in medicine, the food industry and agriculture. – Among them, osthole has been widely used in agriculture as an insecticidal and bacteriostatic pesticide. , In addition, the introduction of coumarin parent nucleus into the structure of common fungicides can also improve its anti-fungal activity. For example, the microbicide eugenicide has excellent control effect on cucumber downy mildew and apple tree rot, which is obtained by introducing coumarin parent nucleus into the structure of traditional methoxyacrylate fungicide .…”

Recent Advances on Sustainable Synthesis of Furocoumarins

“…Coumarin is an important class of naturally occurring oxygen‐containing heterocyclic compounds and is found in a variety of plants like tonka bean, sweet clove, cinnamon, bison grass, woodruff etc [1] . Coumarin and its derivatives possess a wide range of pharmacological activities like antitumor, anti‐HIV, antibacterial, anticoagulant, anticonvulsant, antiprotozoal, antimicrobacterial, antimutagenic, anti‐psoriasis, anti‐inflammatory, CNS‐stimulants etc [2–8] . Among the fused coumarin system, furocoumarin is a fusion of furan ring with coumarin in either 2,3‐ or 3,2‐arrangement, at the c, f, g or h bonds of the coumarin system Figure 1.…”

“…[1] Coumarin and its derivatives possess a wide range of pharmacological activities like antitumor, anti-HIV, antibacterial, anticoagulant, anticonvulsant, antiprotozoal, antimicrobacterial, antimutagenic, anti-psoriasis, anti-inflammatory, CNS-stimulants etc. [2][3][4][5][6][7][8] Among the fused coumarin system, furocoumarin is a fusion of furan ring with coumarin in either 2,3-or 3,2-arrangement, at the c, f, g or h bonds of the coumarin system Figure 1. These fused coumarins are known to have important active pharmaceutical ingredients (API).…”

Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs

“…In this regard, several biologically active families of organic compounds have been found [23][24][25][26]. It is estimated that approximately 3000 entities have been identified from marine sources in which some of them have provided valuable information in the search of new therapies [27]. These sophisticated skeletons have created great interest in marine pharmacology which has The chance to carry out organic synthetic transformations more safely, cleanly, and with shorter reaction times has attracted the attention of the pharmaceutical industry.…”