Recent advances in artificial nerve conduit design: Strategies for the delivery of luminal fillers

Pabari, Amit; Yang, Shi Yu; Mosahebi, Afshin; Seifalian, Alexander M.

doi:10.1016/j.jconrel.2011.07.001

Cited by 65 publications

(57 citation statements)

References 88 publications

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“…3,4 However, this treatment has several drawbacks, including donor site morbidity, the scarcity of available donor tissue, and the frequent incidence of the formation of donor-site neuroma. 5,6 Nerve conduits (NCs) have been developed as an attractive alternative because they can restore the nerve pathway (which is a prerequisite for successful regeneration) while avoiding the disadvantages of autologous transplants. [7][8][9] NCs have been applied in a clinical setting and have been reported to be beneficial for patients.…”

Section: Introductionmentioning

confidence: 99%

c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth

Huang

Quan

Liu

et al. 2015

Tissue Engineering Part A

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Section: Introductionmentioning

confidence: 99%

c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth

Huang

Quan

Liu

et al. 2015

Tissue Engineering Part A

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“…The field of bioengineering nerve conduits for regenerative medicine is advancing rapidly [102,103]. Despite the tremendous amount of research conducted in the search for appropriate materials for nerve conduits, the FDA currently approves only a few materials for that purpose, namely PGA, Type-I collagen, PLCL, and PVA.…”

Section: Discussionmentioning

confidence: 99%

Biochemical engineering nerve conduits using peptide amphiphiles

Tan

Rajadas

Seifalian

2012

Journal of Controlled Release

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Peripheral nerve injury is a debilitating condition. The gold standard for treatment is surgery, requiring an autologous nerve graft. Grafts are harvested from another part of the body (a secondary site) to treat the affected primary area. However, autologous nerve graft harvesting is not without risks, with associated problems including injury to the secondary site. Research into biomaterials has engendered the use of bioartificial nerve conduits as an alternative to autologous nerve grafts. These include synthetic and artificial materials, which can be manufactured into nerve conduits using techniques inspired by nanotechnology. Recent evidence indicates that peptide amphiphiles (PAs) are promising candidates for use as materials for bioengineering nerve conduits. PAs are biocompatible and biodegradable protein-based nanomaterials, capable of self-assembly in aqueous solutions. Their self-assembly system, coupled with their intrinsic capacity for carrying bioactive epitopes for tissue regeneration, form particularly novel attributes for biochemically-engineered materials. Furthermore, PAs can function as biomimetic materials and advanced drug delivery platforms for sustained and controlled release of a plethora of therapeutic agents. Here we review the realm of nerve conduit tissue engineering and the potential for PAs as viable materials in this exciting and rapidly advancing field.

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“…The peripheral nervous system includes the peripheral autonomic nervous system and the peripheral somatic nervous system [24]. However, terminolateral neurorrhaphy for nerve repair had been confined to somatic nerve in previous studies until Gao,et al [25] reported terminolateral neurorrhaphy between somatic nerve and autonomic nerve, which has different characteristics in the peripheral nervous system.…”

Section: Experimental Models Of Terminolateral Neurorrhaphy Of Autonomentioning

confidence: 99%

Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

He¹,

Gao²,

Wen³

2018

Neuropsychiatry

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Recent advances in artificial nerve conduit design: Strategies for the delivery of luminal fillers

Cited by 65 publications

References 88 publications

c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth

c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth

Biochemical engineering nerve conduits using peptide amphiphiles

Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

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