Recent advances in anti-HIV natural products

Singh, Inder Pal; Bodiwala, Hardik S.

doi:10.1039/c0np00025f

Cited by 114 publications

(77 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Segundo Singh et al (2005), o ácido morônico isolado dessa espécie possui atividade anti-HIV e a vantagem, frente a medicamentos alopáticos, de apresentar baixa toxicidade. Além do potencial medicinal, possui potencial paisagístico em função da coloração e textura da casca e arquitetura da copa, podendo ser utilizada na arborização urbana (Marchiori & Sobral, 1997).…”

Section: Espéciesunclassified

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

et al. 2016

View full text Add to dashboard Cite

RESUMOObjetivou-se descrever o padrão florístico-estrutural, as características ecológicas e os potenciais das Myrtaceae na bacia hidrográfica do Rio Caveiras. As comunidades de Myrtaceae estudadas localizam-se no Planalto Sul Catarinense, Lages, São José do Cerrito e Urupema. Foram instaladas quatro blocos por município, totalizando 30 mil m 2 de área amostral, nos quais todos os espécimes de Myrtaceae com diâmetro à altura do peito (DAP) ≥ 5 cm foram amostrados. A estrutura da comunidade de Myrtaceae foi avaliada pelos descritores fitossociológicos e a suficiência amostral foi verificada utilizando-se o método de rarefação. As abordagens ecológicas e indicações de uso não madeireiro basearam-se em bibliografia especializada e base de dados científicos. Foram amostrados 1.480 exemplares de Myrtaceae pertencentes a 21 espécies e 11 gêneros. As espécies mais abundantes foram Myrceugenia euosma, Siphoneugena reitzii e Myrcia palustris, as quais representaram mais de 50% da estrutura da comunidade. Quanto à classificação ecológica, destacou-se o grupo das secundárias iniciais (57%). As espécies amostradas são indicadas para restauração de áreas alteradas, usos ornamentais (100%) e fitoterápicos (60%). Apesar da representatividade e potencialidades das Myrtaceae, ainda são necessárias pesquisas para embasar a conservação via plano de manejo.Palavras-chave: classificação ecológica, restauração de áreas alteradas, uso fitoterápico. Myrtaceae in the Caveiras River Basin: Ecological Characteristics and Non-timber Uses ABSTRACTThis study aimed to describe the floristic-structural pattern, ecological characteristics and potentials of Myrtaceae in the Caveiras River Basin. The studied Myrtaceae communities are localized in Santa Catarina Southern Plateau -municipalities of Lages, São José do Cerrito and Urupema. Four sampling units were installed in each municipality, totaling a sampling area of 30,000 m 2 . All Myrtaceae individuals with DBH ≥ 5 cm were surveyed within the sampling units. The Myrtaceae community structure was assessed through phytosociological descriptors and the sampling sufficiency was verified using the rarefaction method. The ecological approach, as well as the indication of non-timber use of Myrtaceae resources was inferred from a specialized bibliography and scientific database. 1,480 Myrtaceae individuals were sampled, totaling 21 species and 11 genera. The most abundant species were Myrceugenia euosma, Siphoneugena reitzii and Myrcia palustris, which represent more than 50% of the community structure. Regarding the ecological classification, the late secondary group was the most expressive (57%). The sampled

show abstract

Section: Espéciesunclassified

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

et al. 2016

View full text Add to dashboard Cite

show abstract

“…They also have pronounced anti-HIV activity and have been proposed in combination with other anti-HIV drugs for therapeutic purposes. 14 Lastly, a number of natural and synthetic coumarins have been shown to have clinically relevant anticancer activities.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking

et al. 2014

View full text Add to dashboard Cite

Here the "Molecular Lego" approach was used to achieve the first reported electrochemical signal of human CYP2A6 and to improve its catalytic efficiency on electrode surfaces. The enzyme was fused at the genetic level to flavodoxin from Desulfovibrio vulgaris(FLD) to create the chimeric CYP2A6-FLD. Electrochemical characterization by cyclic voltammetry shows clearly defined redox transitions of the haem domain in both CYP2A6 and CYP2A6-FLD.Electrocatalysis experiments using coumarin as substrate followed by fluorimetric quantification of the product were performed with immobilised CYP2A6 and CYP2A6-FLD. Comparison of the kinetic parameters showed that coumarin catalysis was carried out with a higher efficiency by the immobilised CYP2A6-FLD, with a calculated kcat value significantly higher (P<0.005) than that of CYP2A6, while the affinity for the substrate (KM) remained unaltered. The chimeric system was also successfully used to demonstrate the inhibition of the electrochemical activity of the immobilised CYP2A6-FLD, towards both coumarin and nicotine substrates, by tranylcypromine, a potent and selective CYP2A6 inhibitor.This work shows that CYP2A6 turnover efficiency is improved when the protein is linked to FLD redox module and this strategy can be utilized for the development of new clinically relevant biotechnological approaches suitable for deciphering the metabolic implications of CYP2A6 polymorphism and for the screening of CYP2A6 substrates and inhibitors.

show abstract

“…Así mismo, los taninos se detectaron en la fracción de metanol y la fracción soluble en acetona dio positivo el ensayo para antraquinonas (Tabla 1). Estudios fitoquímicos realizados sobre especies del género Vismia, revelan que este género es una buena fuente de xantonas, antraquinonas, terpenos, esteroles, polifenoles y flavonoides; este hecho es relevante, debido a que este estudio reveló que el extracto de la especie Vismia cayennensis, colectada en latitudes venezolanas, posee en su composición química, muchas de estas familias de metabolitos secundarios con actividades biológicas (Singh et al, 2005;Nguemeving et al, 2006;Epifano et al, 2007;Noungoue et al, 2007;Yadav et al, 2016;Buitrago et al, 2016;Oliveira et al, 2017).…”

Section: Resultados Y Discusión 31 Análisis Fítoquímicounclassified

“…Además, de los frutos de esta especie, se ha aislado el ácido crisofánico, physcion, isocariofileno, β-selineno y trans-α-farneseno (Hussain et al, 2012;Kumar et al, 2013) y de sus hojas se obtuvieron cuatro nuevas Vismiafenonas D, E, F y G. Reportándose que la Vismiafenona D exhibió actividad inhibitoria HIV (Singh et al, 2005). Esta planta representa un buena fuente de sustancias bioactivas; sin embargo, la biosíntesis de estos metabolitos se ve drásticamente influenciada por el hábitat al cual está sometida una especie para su crecimiento, desarrollo y supervivencia.…”

Section: Introductionunclassified

Estudio fitoquímico y biológico preliminar de la corteza (tallo) de Vismia cayennensis proveniente del estado Amazonas, Venezuela.// Phytochemical and biological preliminary study of Vismia cayennensis bark (steam) from Amazonas state, Venezuela

Marín¹,

Regnault

Maillo³

et al. 2017

View full text Add to dashboard Cite

ResumenSe realizó un estudio químico y biológico preliminar de la especie Vismia cayennensis, colectada en el estado Amazonas, Venezuela. El ensayo antibacteriano del extracto de la corteza de la planta reveló una inhibición significativa de los microorganismos Escherichia coli, Shigella sp. y Staphylococcus aureus. Además, tres de las cincos fracciones solubles en solventes de distintas polaridades, específicamente las de cloroformo, acetona y agua, mantuvieron de manera moderada, esta actividad frente a la cepa Shigella sp. El extracto hidroalcohólico de la planta y la fracción soluble en cloroformo, exhibieron un efecto antiinflamatorio apreciable. Los ensayos de citotoxicidad realizados por los métodos de (3-(4,5-dimetiltiazol-2-il)-5-(3-carboximetoxifenil)-2-(4-sulfofenil)-2H-tetrazolio)/metosulfato de fenazina (MTS/PMS) y sulforodamina B, revelaron que sólo la fracción soluble en agua presenta efecto citotóxico. Adicionalmente, se realizó un estudio fitoquímico obteniéndose información de la presencia de algunas familias de metabolitos secundarios, tales como flavonoides, saponinas, taninos, polifenoles, antraquinonas, triterpenos y esteroles. Se puede inferir que la corteza del tallo de la planta V. cayennensis, es una fuente promisoria de metabolitos secundarios bioactivos. Palabras Clave: Actividad anti-inflamatoria; citotoxicidad; Escherichia coli; metabolitos secundarios; Shigella sp; Vismia cayennensis. AbstractA chemical and biological preliminary study of the species Vismia cayennensis, collected in the Amazonas state, Venezuela. The antibacterial test of plant bark extract showed significant inhibition in Escherichia coli, Shigella sp and Staphylococcus aureus. In addition, three of the five soluble fractions of different polarity solvents, specifically those of chloroform, acetone and water, maintained moderately active against Shigella sp strain. The hydroalcoholic extract of the plant and the fraction soluble in chloroform, exhibited a significant antiinflammatory effect. Cytotoxicity tests performed by the methods of (3-(4,5-dimetiltiazol-2-yl)-5-(3-carboximetoxifenil)-2-(4-sulfophenyl)-2H-tetrazolium)/phenazine methosulfate of (MTS/PMS) and sulforhodamine B, revealed that only has water soluble cytotoxic effect. Additionally, a study phytochemical obtained information on the presence of some families of secondary metabolites such as flavonoids, saponins, tannins, polyphenols, anthraquinones, triterpenes and sterols. It can be inferred that the stem bark of the plant V. cayennensis, is a promising source of bioactive secondary metabolites.

show abstract

Recent advances in anti-HIV natural products

Cited by 114 publications

References 131 publications

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

Myrtaceae na Bacia do Rio Caveiras: Características Ecológicas e Usos Não Madeireiros

Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking

Estudio fitoquímico y biológico preliminar de la corteza (tallo) de Vismia cayennensis proveniente del estado Amazonas, Venezuela.// Phytochemical and biological preliminary study of Vismia cayennensis bark (steam) from Amazonas state, Venezuela

Contact Info

Product

Resources

About