Recent advances in and potential utilities of paper-based electrochemical sensors: beyond qualitative analysis

Gebretsadik, Tesfay; Belayneh, Tilahun; Gebremichael, Sosina; Linert, Wolfgang; Thomas, Madhu; Berhanu, Tarekegn

doi:10.1039/c8an02463d

Cited by 45 publications

(15 citation statements)

References 80 publications

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Section: Electrical/combined Approaches To Sensingmentioning

confidence: 99%

“…As noted previously, paper based electrochemical devices have recently gained attention because of the attractive properties of paper [ 55 ]. Paper based electrochemical sensors have been demonstrated in the literature for the detection of health biomarkers (e.g., dopamine), inorganic toxic contaminants (e.g., Pd and Cd in sea water) and organic toxic contaminants (e.g., nerve agents in wastewater) [ 55 ]. Recently, a paper based electrochemical sensor chip made of graphene and gold nanoparticles conjugated with antisense oligonucleotides was developed for the rapid detection of SARS-CoV-2 viral RNA with a detection limit of 6.9 copies/μL ( Fig.…”

Section: Electrical/combined Approaches To Sensingmentioning

confidence: 99%

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Nanobiotechnology enabled approaches for wastewater based epidemiology

Rahman

Kang

Wang

et al. 2021

TrAC Trends in Analytical Chemistry

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The impacts of the ongoing coronavirus pandemic highlight the importance of environmental monitoring to inform public health safety. Wastewater based epidemiology (WBE) has drawn interest as a tool for analysis of biomarkers in wastewater networks. Wide scale implementation of WBE requires a variety of field deployable analytical tools for real-time monitoring. Nanobiotechnology enabled sensing platforms offer potential as biosensors capable of highly efficient and sensitive detection of target analytes. This review provides an overview of the design and working principles of nanobiotechnology enabled biosensors and recent progress on the use of biosensors in detection of biomarkers. In addition, applications of biosensors for analysis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are highlighted as they relate to the potential expanded use of biosensors for WBE-based monitoring. Finally, we discuss the opportunities and challenges in future applications of biosensors in WBE for effective monitoring and investigation of public health threats.

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Section: Electrical/combined Approaches To Sensingmentioning

confidence: 99%

Section: Electrical/combined Approaches To Sensingmentioning

confidence: 99%

Nanobiotechnology enabled approaches for wastewater based epidemiology

Rahman

Kang

Wang

et al. 2021

TrAC Trends in Analytical Chemistry

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“…Paper is a relatively cheap substrate and it has a variety of chemical and physical properties such as chemical composition, mechanical strength, various aperture and thickness, wettability, and liquid absorption capacity. [90] In addition, a paper substrate can be easily modified and customized for specific applications, thus it can be used for a wide range of analytical diagnostics. Wang et al [91] first demonstrated a paper-based microfluidics smartphone electrochemical biosensor for unlabeled WBC counting.…”

Section: Recent Development Of Leucocyte Counting At Pocmentioning

confidence: 99%

White blood cell counting at point‐of‐care testing: A review

Luo

Chen

2020

Electrophoresis

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White blood cells, which are also called leukocytes, are found in the immune system that are involved in protecting the body against infections and foreign invaders. Conventional methods of leukocyte analysis provide valuable and accurate information to medical specialists. Analyzing and diagnosing of a disease requires a combination of multiple biomarkers, in some cases, however, such as personal health care, this will occupy some medical resources and causes unnecessary consumption. Traditional method (such as flow cytometer) for WBC counting is time and labor consuming. Compared to gold standard (flow‐based fraction/micropore filtration) or improved filtration methods for WBC counting, this is still a lengthy and time consuming process and can lead to membrane fouling due to the rapid accumulation of biological materials. Therefore, the analysis of WBC counts requires more compact and efficient equipment. The microfluidic technologies, powered by different field (force, thermal, acoustic, optical, magnetic) and other methods for leukocyte counting and analysis, are much cost‐efficient and can be used in in‐home or in resource‐limited areas to achieve Point‐of‐Care (POC). In this review, we highlight the mainstream devices that have been commercialized and extensively employed for patients for WBC counting, Next, we present some recent development with regards to leucocyte counting (mainly microfluidic technologies) and comment on their relative merits. We aim to focus and discuss the possibility of achieving POC and help researchers to tackle individual challenges accordingly. Finally, we offer some technologies in addition to previous detection devices, such as image recognition technology and cloud computing, which we believe have great potential to further promote real‐time detection and improve medical diagnosis.

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“…Different types of papers can be used, depending on analytical requirements (Cinti et al, 2019 ). Since the field of paper-based printed electrochemical sensor is quite vast, we would like to invite the reader to refer to detailed review papers inherent this topic (Martinez et al, 2010 ; Hu et al, 2014 ; Medina-Sánchez et al, 2015 ; Jia et al, 2016 ; Chouler et al, 2018 ; Gebretsadik et al, 2019 ; Smith et al, 2019 ). Recently, bacterial-derived cellulose substrates have been proposed for the development of screen-printed sensors for the determination of lactate (Gomes et al, 2020 ) and heavy metals in sweat (Silva et al, 2020 ), respectively.…”

Section: Novel Materials For Printingmentioning

confidence: 99%

Sustainable Printed Electrochemical Platforms for Greener Analytics

Sfragano

Laschi²,

Palchetti

2020

Front. Chem.

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The development of miniaturized electrochemical platforms holds considerable importance for the in situ analytical monitoring of clinical, environmental, food, and forensic samples. However, it is crucial to pay attention to the sustainability of materials chosen to fabricate these devices, in order to decrease the amount and the impact of waste coming from their production and use. In the framework of a circular economy and an environmental footprint reduction, the electrochemical sensor production technology must discover the potentiality of innovative approaches based on techniques and materials that can satisfy the needs of environmental-friendly and greener analytics. The aim of this review is to describe some of the printing technologies most used for sensor production, including screen-printing, inkjet-printing, and 3D-printing, and the low-impact materials that are recently proposed for these techniques, such as polylactic acid, cellulose, silk proteins, biochar.

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Recent advances in and potential utilities of paper-based electrochemical sensors: beyond qualitative analysis

Abstract: Paper based electrochemical sensors (PESs) are simple, low-cost, portable and disposable analytical sensing platforms that can be applied in clinical diagnostics, food quality control and environmental monitoring.

Cited by 45 publications

References 80 publications

Nanobiotechnology enabled approaches for wastewater based epidemiology

Nanobiotechnology enabled approaches for wastewater based epidemiology

White blood cell counting at point‐of‐care testing: A review

Sustainable Printed Electrochemical Platforms for Greener Analytics

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