Sustainable Printed Electrochemical Platforms for Greener Analytics

Sfragano, Patrick Severin; Laschi, Serena; Palchetti, Ilaria

doi:10.3389/fchem.2020.00644

Cited by 34 publications

(14 citation statements)

References 64 publications

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“…Screen printing is a high-speed, cost-effective, reproducible, and large-scale process for the fabrication of sensor electrodes or devices by the transfer of inks onto flexible substrates through a stencil mask [ 37 , 38 ]. The properties of functional inks, such as their conductivity, concentration, viscosity, and flexibility, are key factors for realizing high-performance wearable chemical sensors [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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Highlights Ultrathin and defect-free graphene ink is prepared through a high-throughput fluid dynamics process, resulting in a high exfoliation yield (53.5%) and a high concentration (47.5 mg mL−1). A screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and good mechanical flexibility. An electrochemical sodium ion sensor based on graphene ink exhibits an excellent potentiometric sensing performance in a mechanically bent state. Real-time monitoring of sodium ion concentration in sweat is demonstrated. Abstract Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible devices. However, the application of graphene fillers is limited by their restricted mass production and the low concentration of their suspensions. In this study, a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process. A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL−1 for graphene ink. The screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and maintains high conductivity under mechanical bending, compressing, and fatigue tests. Based on the as-prepared graphene ink, a printed electrochemical sodium ion (Na+) sensor that shows high potentiometric sensing performance was fabricated. Further, by integrating a wireless electronic module, a prototype Na+-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a volunteer. The scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost, reproducible, and large-scale printing of flexible and wearable electronic devices.

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Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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“…A noteworthy example of its detection is the use of the aforementioned RAFT polymerization process to augment sensitivity, employing the peptide sequence LRRASLGGGGC as the recognition substrate [91,92]. through anodic stripping of AgNPs, using CB [8] as macrocyclic receptor to bind two aromatic amino acid residues via host-guest interactions, reprinted with permission from [76]; (b) signal-on MMP's activity detection using a carboxyl groupfree recognition peptide as proteolytic substrate, immobilised via Au-S self-assembly. Grafting of Fc polymers through eRAFT polymerization of ferrocenylmethyl methacrylate (FcMMA), reprinted with permission from [65]; (c) GO/AgNPs nanocomposite for the determination of PSA on Au electrode by means of linear sweep voltammetry (LSV), reprinted with permission from [83].…”

Section: Peptides As Substrate and Signal Development Agents In Catalytic Biosensorsmentioning

confidence: 99%

“…Electrochemical biosensors are powerful tools that allow for cost-effective, easy, and fast detection and/or monitoring of analytes in clinical diagnostics [7][8][9][10][11][12], and are often employed in the framework of point-of-care testing (PoCT). Peptides represent a promising class of affinity biorecognition elements that can be coupled to electrochemical transducers.…”

Section: Introductionmentioning

confidence: 99%

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

et al. 2021

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Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.

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“…A printed electrochemical sensor consists of layers of conductive as well as dielectric pastes printed on an inert substrate [ 66 ]. Pastes are mainly consisting of nanoparticles colloidal suspension, containing additive, solvent, and binders.…”

Section: Tips On Spes Manufacture and Customizationmentioning

confidence: 99%

Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses

Sher

Faheem

Asghar

et al. 2021

TrAC Trends in Analytical Chemistry

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There is a growing interest in the development of portable, cost-effective, and easy-to-use biosensors for the rapid detection of diseases caused by infectious viruses: COVID-19 pandemic has highlighted the central role of diagnostics in response to global outbreaks. Among all the existing technologies, screen-printed electrodes (SPEs) represent a valuable technology for the detection of various viral pathogens. During the last five years, various nanomaterials have been utilized to modify SPEs to achieve convincing effects on the analytical performances of portable SPE-based diagnostics. Herein we would like to provide the readers a comprehensive investigation about the recent combination between SPEs and various nanomaterials for detecting viral pathogens. Manufacturing methods and features advances are critically discussed in the context of early-stage detection of diseases caused by HIV-1, HBV, HCV, Zika, Dengue, and Sars-CoV-2. A detailed table is reported to easily guide readers toward the “right” choice depending on the virus of interest.

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Sustainable Printed Electrochemical Platforms for Greener Analytics

Cited by 34 publications

References 64 publications

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses

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