Recent advances in analysis of bisphenols and their derivatives in biological matrices

Ocaña-Ríos, Irán; Olmos-Espejel, José de Jesús; Donkor, Kingsley K.

doi:10.1007/s00216-021-03668-y

Cited by 7 publications

(6 citation statements)

References 115 publications

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“…The values wee 0.5–2.1 ng/mL and 1.4–6.3 ng/mL for LOD and LOQ, respectively, which are the levels similar to those found in real various human samples [ 2 ]. Moreover, y-intercepts obtained from the calibration curves indicate the small influence of the matrix.…”

Section: Resultssupporting

confidence: 60%

“…The most known compound from bisphenol group is bisphenol A. BPA is used as an additive to polycarbonate plastics, in the production of epoxy resigns or as a protective layer on the inside of the can protecting the metal against corrosion. BPA has been found in various body fluids such as urine, blood, breast milk, amniotic fluid or saliva and in tissues such as liver, brain or adipose tissue [ 2 , 3 , 4 ]. BPA has been suspected to have toxic effects such as causing endocrine disruption, heart disease, obesity, diabetes, hepatotoxicity, neurotoxicity, genotoxicity, mutagenicity, immunotoxicity, carcinogenicity or teratogenicity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most popular chromatographic technique for the determination of bisphenols in human breast milk samples is liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). LC-MS/MS offers low values of limits of detection (LOD) and quantification (LOQ) below 1 ng/mL, combined with a reliability of the obtained results [ 2 ]. One of the common sample preparation techniques used during biomonitoring of BPs in human breast milk samples is QuEChERS [ 4 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD

Szubartowski

Tuzimski

2023

Molecules

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Plastic pollution, where bisphenol A (BPA) is widely used in its production, has gained popularity. BPA omnipresence and toxicity, especially for infants, has led food safety authorities to place restrictions on BPA usage. It has led to the introduction of the marked ‘BPA-free’-labelled products, where BPA is often replaced by other bisphenols (BPs) which are suspected of being similar or even more toxic than BPA. Moreover, the free forms of BPs are more dangerous than their conjugated forms and the conjugation of BPs is less effective in infants than in adults. Considering that human breast milk is the main source of nutrition for infants, the constant biomonitoring not only of BPA, but the wider group of BPs in such crucial matrices seems to be vital. In this study, a fast, simple, ‘green’ and cost-effective DLLME-based extraction technique combined with HPLC-FLD was optimized for the determination of seven selected bisphenols simultaneously. The procedure has satisfactory recovery values of 67–110% with the most RSD% at 17%. The LODs and LOQs ranged from 0.5 ng/mL to 2.1 ng/mL and 1.4 ng/mL to 6.3 ng/mL, respectively. The procedure was successfully applied to the biomonitoring of free forms of BPs in 10 real human breast milk samples.

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Section: Resultssupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD

Szubartowski

Tuzimski

2023

Molecules

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“…In this study, we propose a DLLME-based method for the simultaneous determination of selected bisphenols using HPLC-FLD. The selected analytes have been previously found in other biological matrices, such as urine or breast milk [30]. Compared to our previous study, we obtained similar or higher recovery values and limits of quantification (LOQs) while keeping the same small sample volume, which is crucial considering the low availability of amniotic fluid.…”

Section: Introductionsupporting

confidence: 62%

“…The low concentration of analytes found in biological samples combined with complex matrices requires not only effective sample preparation but also a very sensitive and reliable separation technique, such as liquid chromatography or gas chromatography. The most common technique is liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), with which high sensitivity and reliability can be achieved for the obtained results [30].…”

Section: Introductionmentioning

confidence: 99%

Application of High-Performance Liquid Chromatography Combined with Fluorescence Detector and Dispersive Liquid–Liquid Microextraction to Quantification of Selected Bisphenols in Human Amniotic Fluid Samples

Szubartowski

Tuzimski

2022

IJERPH

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Bisphenol A (BPA) is a widely produced chemical worldwide found in numerous everyday products. Its endocrine-disrupting properties and omnipresence have aroused concern and led to several restrictions on its use. These restrictions and growing public awareness about the toxicity of BPA have resulted in market products labeled ”BPA-free”, with BPAs often being replaced by other bisphenols. This is why constant biomonitoring of bisphenol levels in various body fluids and tissues is essential. In this study, we propose the use of simple, cost-effective high-performance liquid chromatography coupled with the fluorescence detector (HPLC-FLD) method for the determination of simultaneously selected bisphenols in amniotic fluid. For the sample preparation, a fast, simple, and ”green” dispersive liquid–liquid microextraction (DLLME) method was used, achieving mean recovery values in the range of 80.9–115.9% with relative standard deviations below 12% for all analytes. Limits of quantification (LOQs) determined in the amniotic fluid matrix ranged from 6.17 to 22.72 ng/mL and were obtained from a calibration curve constructed using least-squares linear regression analysis for all cases. The presented sample preparation procedure can be easily adopted for LC-MS analysis.

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Covalent organic framework reinforced hollow fiber bar for extraction and detection of bisphenols from beverages

Cheng,

Qiao,

Zhang

et al. 2024

Food Chemistry

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Recent advances in analysis of bisphenols and their derivatives in biological matrices

Cited by 7 publications

References 115 publications

A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD

A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD

Application of High-Performance Liquid Chromatography Combined with Fluorescence Detector and Dispersive Liquid–Liquid Microextraction to Quantification of Selected Bisphenols in Human Amniotic Fluid Samples

Covalent organic framework reinforced hollow fiber bar for extraction and detection of bisphenols from beverages

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