Recent advances in aerosolised drug delivery

Chandel, Akshay; Goyal, Amit K.; Ghosh, Goutam; Rath, Goutam

doi:10.1016/j.biopha.2019.108601

Cited by 115 publications

(51 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aerosol therapy is generally used in critical pulmonary treatment [118]. There are several advantages that make aerosol drug delivery a preferred route of administration over various other types of dosage forms: It can be self-administered by patients, parents, and caregivers [119][120][121][122]. Various quantities of medication can be quickly released from a container without The risk of contamination or exposure to The remaining medicines [121,122].…”

Section: Aerosolizationmentioning

confidence: 99%

State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery

Brave

MacLoughlin

2020

IJMS

View full text Add to dashboard Cite

Respiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary disease), ARDS (acute respiratory distress syndrome), and COVID-19. Novel and innovative therapies such as advanced therapy medicinal products (ATMPs) are still in early development. However, they have exhibited significant potential preclinically and clinically. There are several longitudinal studies published, primarily focusing on the use of cell therapies for respiratory diseases due to their anti-inflammatory and reparative properties, thereby hinting that they have the capability of reducing mortality and improving the quality of life for patients. The primary objective of this paper is to set out a state of the art review on the use of aerosolized MSCs and their potential to treat these incurable diseases. This review will examine selected respiratory and pulmonary diseases, present an overview of the therapeutic potential of cell therapy and finally provide insight into potential routes of administration, with a focus on aerosol-mediated ATMP delivery.

show abstract

Section: Aerosolizationmentioning

confidence: 99%

State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery

Brave

MacLoughlin

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…During nebulization, antibiotic liquid aerosols are generated by mechanical mechanisms like soft mist inhaler, human powered nebulizer or electrical mechanisms such as vibrating mesh technology, jet nebulizer and ultrasonic wave nebulizer [67]. Recent advances in nebulizer design have been reviewed elsewhere [68]. Conventional jet nebulizers generally have low drug delivery efficiencies and compared to the other types of nebulizers, noisy working and heavy weight are the biggest drawbacks of the jet nebulizer [69].…”

Section: Nebulizationmentioning

confidence: 99%

Pulmonary drug delivery systems of antibiotics for the treatment of respiratory tract infections

Csóka

Karimi

Mukhtar

et al. 2019

APH

View full text Add to dashboard Cite

Respiratory infections cause an extensive health problem in the world. The common treatment for respiratory infections is the administration of antibiotics orally or parenterally in a high dose. Unfortunately, these therapies of high-dose antimicrobials have many disadvantages, such as severe side effects. Consequently, the development of an inhaled formulation provides the delivery of the therapeutic dose of the drug to the organ of interest without overt systemic effects. Novel technological advances have led to the development of inhaled antibiotics. Recent particle engineering techniques for dry powder inhalers (DPI) or mesh nebulizers have higher aerosolization efficiencies and promote the delivery of high-dose antibiotics to the lungs. However, advanced formulation strategies are in high demand for the development of new formulations for more types of antibiotics. Despite all the current research, patient compliance with pulmonary dosage forms remains to be very low because of the inappropriate administration techniques. Hence, this review focuses on three key aspects of the pulmonary dosage forms of antibiotics; the marketed products, the formulation approaches under research and innovative formulation strategies for achieving drug delivery through the respiratory tract.

show abstract

“…Advancement in modern drug delivery methods have unlocked numerous opportunities in the treatment and diagnosis of diseases (Chandel et al 2019;Jain 2014;Li et al 2017;Lim et al 2018;Pandey et al 2019). Ingestion, inhalation, absorption, and intravenous injection are the most common methods of delivering drugs (Jain 2014).…”

Section: Introductionmentioning

confidence: 99%

Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction

et al. 2020

View full text Add to dashboard Cite

The need for novel, minimally invasive diagnostic, prognostic, and therapeutic biomedical devices has garnered increased interest in recent years. Microneedle (MN) technology has stood out as a promising new method for drug delivery, as well as extraction of interstitial fluid (ISF). ISF comprises a large portion of the extracellular fluid in living organisms yet remains inadequately characterized for clinical applications. Current MN research has focused on the fabrication of needles with different materials like silicone, carbon, and metals. However, little effort has been put forth into improving MN holders and patches that can be used with low cost MNs, which could effectively change how MNs are attached to the human body. Here, we describe different 3D-printed MN holders, printed using an MJP Pro 2500 3D printer, and compare the ISF extraction efficiencies in CD Hairless rats. We varied design parameters that may affect the skin-holder interface, such as throat thickness, tip curvature, and throat diameter. MN arrays, with insertion depths of 1500 lm, had extraction efficiencies of 0.44 ± 0.35, 0.85 ± 0.64, 0.32 ± 0.21, or 0.44 ± 0.46 ll/min when designed with flat, concave, convex, or bevel profile geometries, respectively. Our results suggest ISF extraction is influenced by MN holder design parameters and that a concave tip design is optimal for extracting ISF from animals. The future direction of this research aims to enable a paradigm in MN design that maximizes its efficiency and engineering performance in terms of volume, pressure, and wearability, thereby automatizing usage and reducing patient intervention to ultimately benefit remote telemedicine.

show abstract

Recent advances in aerosolised drug delivery

Cited by 115 publications

References 49 publications

State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery

State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery

Pulmonary drug delivery systems of antibiotics for the treatment of respiratory tract infections

Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction

Contact Info

Product

Resources

About