Recent advances in 3D printed wound dressings

Nadhif, Muhammad Hanif; Assyarify, Hanif; Irsyad, Muhammad; Pramesti, Arindha R.; Suhaeri, Muhammad

doi:10.1063/5.0047183

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…In recent years, 3D printing methods have gained increasing interest, particularly for producing wound dressings. , However, a limited number of studies have reported the application of drug-loading, for instance, natural phytotherapeutic agents, to improve the lack of antibacterial properties of conventional wound dressings. ,,, In this regard, the current study focuses on incorporating CLV into 3D-printed hydrogels to enhance not only the antioxidant activity but also to induce antibacterial properties. As illustrated in Figure a,b, the antibacterial activity of 3D-printed ALG-XAN hydrogels containing various concentrations of CLV has been tested using contact turbidity assay with both gram-positive (S.…”

Section: Resultsmentioning

confidence: 99%

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

Ünalan

Schruefer

Schubert

et al. 2023

ACS Biomater. Sci. Eng.

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This study aimed to develop three-dimensional (3D)-printed hydrogels containing phytotherapeutic agents as multifunctional wound dressings. In this regard, 3D-printed sodium alginate (ALG)−xanthan gum (XAN) hydrogels incorporated with different clove essential oil (CLV) concentrations were produced by the extrusion-based 3D-printing technology. Rheology measurements, filament fusion, and filament collapse analyses indicated that XAN's blending overcame the challenges associated with ALG's printability and shape fidelity. Attenuated total reflection-Fourier-transform infrared (ATR-FTIR) spectra and total phenolic content assay confirmed the presence of CLV in the 3D-printed hydrogels. Additionally, the releasing profile showed that CLV exhibited long-term release for up to 28 days. Furthermore, the incorporation of CLV increased 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging while reducing the S. aureus and E. coli relative bacterial viability; thereby, the CLV incorporation enhanced the 3Dprinted ALG−XAN hydrogel antioxidant and antibacterial activity. In addition, anti-inflammatory activity was assessed using Raw 264.7 macrophage-like cells, and the results demonstrated that CLV reduced nitric oxide (NO) concentration in medium, indicating a potential anti-inflammatory effect. Moreover, in vitro cytotoxicity results showed that the incorporation of CLV has no toxic effect on NHDF cells, whereas the proliferation of NHDF cells exhibited a dose-dependent response. In conclusion, the present study shows not only the development of a new ALG-XAN biomaterial ink but also the potential benefit of natural phytotherapeutics incorporated into 3D-printed hydrogels as a multifunctional wound dressing.

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Section: Resultsmentioning

confidence: 99%

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

Ünalan

Schruefer

Schubert

et al. 2023

ACS Biomater. Sci. Eng.

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show abstract

“…Conventional wound dressings in the form of gauze, lint, plasters, and bandages [ 263 ] have not resulted in proper wound-healing management. The 3D-printing technology used to obtain films, foams, hydrogels, hydrocolloids, and smart wound dressings (including stimuli-responsive wound dressings, self-healing wound dressings for motional wounds, and self-removable wound dressings), is a challenge in this emerging field [ 264 ].…”

Section: Discussionmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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“…This printer has a stepper motor coupled with a roller gear to feed a filament through a heating element to realize a 3D construct. 37 The 3D printing parameters were configured using a Simplify3D computer aided manufacturing (CAM) software (Simplify3D, Cincinnati, Ohio). Polylactic acid (PLA; Esun Industrial, Shenzhen, China) was used because it has been successfully used for fabricating simulator molds.…”

Section: Biomechanical Analysis Using Feamentioning

confidence: 99%

Biomechanically Compliant Gynecologic Training Simulator

Nadhif

Irsyad²,

Ocviyanti³

2022

Sim Healthcare

Self Cite

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Introduction: Pap smear training is commonly conducted using simulators before practicing with humans. Unfortunately, existing simulators do not well simulate the biomechanical properties of pelvic tissues, and this may negatively impact the training outcome. In this study, we used finite element analysis (FEA) to identify a material that most accurately simulates pelvic tissues in terms of biomechanical properties for fabricating gynecologic training simulators. The selected material was then used to fabricate a vagina and cervix model using a hybrid technique of fused deposition modeling and molding to qualitatively confirm the structural integrity of the simulator. Methods: The vagina and cervix were reconstructed in a 3-dimensional feature according to geometrical parameters reported in the literature. The biomechanical compliance of the simulators was investigated by comparing 5 materials-RTV615, Dragon Skin 10, Dragon Skin 30, Dragon Skin FX-Pro, and Ecoflex 00-30-and a pelvic tissue model (control) using 2 FEA modules. The structural mechanics module simulated the insertion and opening of a vaginal speculum, and the (1) horizontal opening of the vagina and peak von Mises stress at the anterior and (2) posterior walls of the vagina were obtained. The explicit dynamics module estimated (1) the fracture stress during punch biopsies and (2) maximum perpendicular deformation of the cervix before break. The most biomechanically compliant material was subsequently used to fabricate the simulator using the hybrid technique. Results: From the FEA, the horizontal opening of the vagina, peak von Mises stress at the anterior wall of the vagina, peak von Mises stress at the posterior wall of the vagina fracture stress, and maximum perpendicular deformation of the cervix before break were obtained; the results of Dragon Skin 10 and the control were most similar. Therefore, the simulator was fabricated using the material. A qualitative evaluation of the simulator by the naked eye verified its structural integrity. Conclusions: Of the materials studied, the FEA results showed that Dragon Skin 10 was the most accurate material for simulating pelvic tissues in terms of the biomechanical properties in a gynecologic training simulator. The simulator was also successfully fabricated using the hybrid technique. Further studies may also involve experimental testing to support the simulation results.

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Recent advances in 3D printed wound dressings

Cited by 11 publications

References 40 publications

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

3D-Printed Multifunctional Hydrogels with Phytotherapeutic Properties: Development of Essential Oil-Incorporated ALG-XAN Hydrogels for Wound Healing Applications

Special Features of Polyester-Based Materials for Medical Applications

Biomechanically Compliant Gynecologic Training Simulator

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