Recent Advances Based on Nanomaterials as Electrochemiluminescence Probes for the Fabrication of Sensors

Zhai, Qingfeng; Li, Jing; Wang, Erkang

doi:10.1002/celc.201600898

Cited by 86 publications

(48 citation statements)

References 159 publications

(120 reference statements)

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“…Unlike QDs, these particles have low toxicity, good ECL intensity, and low autofluorescence background. Detailed description of the use of upconversion nanoparticles in ECL is already available in literature (Liu et al, 2014;Gao et al, 2017;Zhai et al, 2017;Gu et al, 2019). Alternative approaches for safe enhancement of CL will be discussed below.…”

Section: First Generation Of Chemiluminescence and Bioluminescencementioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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Tissue imaging has emerged as an important aspect of theragnosis. It is essential not only to evaluate the degree of the disease and thus provide appropriate treatments, but also to monitor the delivery of administered drugs and the subsequent recovery of target tissues. Several techniques including magnetic resonance imaging (MRI), computational tomography (CT), acoustic tomography (AT), biofluorescence (BF) and chemiluminescence (CL), have been developed to reconstruct three-dimensional images of tissues. While imaging has been achieved with adequate spatial resolution for shallow depths, challenges still remain for imaging deep tissues. Energy loss is usually observed when using a magnetic field or traditional ultrasound (US), which leads to a need for more powerful energy input. This may subsequently result in tissue damage. CT requires exposure to radiation and a high dose of contrast agent to be administered for imaging. The BF technique, meanwhile, is affected by strong scattering of light and autofluorescence of tissues. The CL is a more selective and sensitive method as stable luminophores are produced from physiochemical reactions, e.g. with reactive oxygen species. Development of near infrared-emitting luminophores also bring potential for application of CL in deep tissues and whole animal studies. However, traditional CL imaging requires an enhancer to increase the intensity of low-level light emissions, while reducing the scattering of emitted light through turbid tissue environment. There has been interest in the use of focused ultrasound (FUS), which can allow acoustic waves to propagate within tissues and modulate chemiluminescence signals. While light scattering is decreased, the spatial resolution is increased with the assistance of US. In this review, chemiluminescence detection in deep tissues with assistance of FUS will be highlighted to discuss its potential in deep tissue imaging.

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Section: First Generation Of Chemiluminescence and Bioluminescencementioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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“…Nanomaterials and biomolecules are in the same size range, facilitating the formation of hybrids with synergistic properties. They can act as labels of the recognition event or as catalyst for a reaction, as luminophore or as the energy acceptor to lead to an effective ECL resonance energy transfer (ECL-RET) [ 42 ]. Hence, the efficiency of ECL biosensors will be increased due to the use of different nanomaterials, such as graphene, carbon dots, quantum dots, metal nanoclusters, etc.…”

Section: Introductionmentioning

confidence: 99%

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

et al. 2020

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Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the particular case of sensing applications, ECL biosensor unites the benefits of the high selectivity of biological recognition elements and the high sensitivity of ECL analysis methods. Hence, it is a powerful analytical device for sensitive detection of different analytes of interest in medical prognosis and diagnosis, food control and environment. These wide range of applications are increased by the introduction of screen-printed electrodes (SPEs). Disposable SPE-based biosensors cover the need to perform in-situ measurements with portable devices quickly and accurately. In this review, we sum up the latest biosensing applications and current progress on ECL bioanalysis combined with disposable SPEs in the field of bio affinity ECL sensors including immunosensors, DNA analysis and catalytic ECL sensors. Furthermore, the integration of nanomaterials with particular physical and chemical properties in the ECL biosensing systems has improved tremendously their sensitivity and overall performance, being one of the most appropriates research fields for the development of highly sensitive ECL biosensor devices.

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“…Electrogenerated chemiluminescence (ECL) involves the generation of light through an electrochemical stimulus . As analytical technique ECL is far superior to photoluminescence and chemiluminescence in terms of signal to noise ratio and it has been widely used for the ultrasensitive quantification of important biomarkers .…”

Section: Introductionmentioning

confidence: 99%

Photophysical and Electrochemiluminescence of Coumarin‐Based Oxazaborines

et al. 2020

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We describe the synthesis, electrochemistry, photophysics, computational analysis and electrochemiluminescence (ECL) of a new series of oxazaborine molecules. Our strategy is based on the modification of the coumarin-oxazaborine moiety to be directly joined through a carbon-carbon bond, forming donoracceptor (D-A) chromophores. These new structures substantially change the electron distribution as well as photophysical and electrochemical behaviors with a strong effect on the final quantum yield. For all compounds, we observed a very high PL quantum yield (70-75 %) and relatively accessible first oxidation and first reduction. All of these characteristics allow us to study the ECL of these molecules, obtaining a very high ECL efficiency that is four times higher than the standard dyes, opening the application of oxazaborine as bright ECL luminophores.

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Recent Advances Based on Nanomaterials as Electrochemiluminescence Probes for the Fabrication of Sensors

Cited by 86 publications

References 159 publications

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

Photophysical and Electrochemiluminescence of Coumarin‐Based Oxazaborines

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